A RANDOMIZED CONTROLLED TRIAL OF ECHINACEA IN CHILDREN

儿童紫锥菊的随机对照试验

• 批准号: 6451004
• 负责人: James A Taylor
• 金额: $ 0.11万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6451004
• 关键词: Compositae; alternative medicine; clinical research; clinical trials; drug adverse effect; health care service utilization; health services research tag; human subject; human therapy evaluation; middle childhood (6-11); otitis media; plant extracts; pneumonia; preschool child (1-5); respiratory disorder; respiratory disorder chemotherapy; secondary infection; sinusitis

Upper respiratory tract infections (URI's) are a significant health burden in childhood. URI's are a major reason for visits to health care providers, and up to 35% of young children at any given time are taking some over-the-counter cold medication. Unfortunately, data suggest that most of these medications have limited effectiveness. Alternative medical therapies are growing in popularity; in a recent survey of parents of children being seen by pediatricians in Seattle, Washington, 24.2% indicated that their child had been seen by an alternative medicine health care provider, and 53.3% therapies for the treatment of URI's in children. The proposed study is a randomized, double blind, placebo controlled trial of echinacea for the treatment of URI's in children 2-11 years old. The aims of the project are: to determine if echinacea shortens the duration and/or lessens the severity of URI's, if children receiving echinacea for treatment of URI's have a reduced rate of secondary bacterial infections, and to determine if the use of echinacea in patients 2-11 years old is associated with any significant side effects. A two-year study of 600 children is planned. Not only will the results of this study will determine if echinacea, the most popular medicinal herb sold in the United States, is an effective therapy for URI's in children, the study will provide a design framework for future assessments on the efficacy of other complementary and alternative medicines in children.

上呼吸道感染（URI’s）是儿童时期一个重要的健康负担。URI是就医的主要原因，在任何时候，高达35%的幼儿都在服用一些非处方感冒药。不幸的是，数据表明大多数这些药物的效果有限。替代疗法越来越受欢迎；在最近的一项调查中，在西雅图和华盛顿，24.2%的儿童父母表示他们的孩子曾接受过替代医学医疗保健提供者的治疗，53.3%的儿童接受过URI治疗。拟议的研究是一项随机、双盲、安慰剂对照试验，研究紫锥菊治疗2-11岁儿童的URI。该项目的目的是：确定紫锥菊是否缩短了URI的持续时间和/或减轻了URI的严重程度，接受紫锥菊治疗的儿童是否降低了继发性细菌感染的发生率，以及确定2-11岁患者使用紫锥菊是否与任何显著的副作用有关。计划对600名儿童进行为期两年的研究。这项研究的结果不仅将确定在美国销售的最受欢迎的草药紫锥菊是否是儿童URI的有效治疗方法，该研究还将为未来评估其他补充和替代药物对儿童的疗效提供设计框架。

项目成果

Complementary and alternative medicine in pediatric allergic disorders.

• DOI: 10.1097/aci.0b013e328329226f
• 发表时间: 2009-04
• 期刊: Current opinion in allergy and clinical immunology
• 影响因子: 2.8
• 作者: Li XM

Echinacea purpurea for prevention of upper respiratory tract infections in children.

• DOI: 10.1089/acm.2005.11.1021
• 发表时间: 2005-12
• 期刊: Journal of alternative and complementary medicine
• 影响因子: 2.6
• 作者: W. Weber;James A. Taylor;A. Stoep;N. Weiss;L. Standish;C. Calabrese

Efficacy and mechanisms of action of traditional Chinese medicines for treating asthma and allergy.

• DOI: 10.1016/j.jaci.2008.12.026
• 发表时间: 2009-02
• 期刊: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
• 影响因子: 14.2
• 作者: Li, Xiu-Min;Brown, LaVerne
• 通讯作者: Brown, LaVerne