Mentoring and Research in Patient-Oriented Integrative Medicine

以患者为中心的整合医学的指导和研究

• 批准号: 9527491
• 负责人: CHENCHEN WANG
• 金额: $ 18.45万
• 依托单位: TUFTS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-12-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9527491
• 关键词: Acupuncture Therapy; Affect; Applications Grants; Archives; Authorship; Award; Bibliography; Brain; Childhood; Chinese Traditional Medicine; Chronic; Chronic Fatigue Syndrome; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Comparative Study; Complementary Medicine; Discipline; Disease Progression; Doctor' s Degree; Dose; Educational process of instructing; Emotional; Environment; Environmental Risk Factor; Epigenetic Process; Ethics; Family; Fostering; Foundations; Funding; Future; Future Generations; Goals; Grant; Gulf War; Health; Health Promotion; Healthcare; Healthcare Systems; Human; Human Biology; Individual; Infrastructure; Institutes; Integrative Medicine; Integrative Therapy; Investigation; Journals; Massage; Medical; Medicine; Mental Depression; Mental Health; Mental disorders; Mentors; Methodology; Methods; MicroRNAs; Mid-Career Clinical Scientist Award (K24); Military Personnel; Mind-Body Intervention; Mission; Modality; Modeling; Modern Medicine; Morbidity - disease rate; Neurobiology; Neurosciences; Neurosciences Research; Outcome; Pain; Pain management; Pathway interactions; Patients; Peer Review; Persistent pain; Personal Satisfaction; Physicians; Physiological; Physiology; Pilot Projects; Politics; Population; Predisposition; Progress Reports; Psychology; Publications; Publishing; Quality of life; Records; Regimen; Research; Research Personnel; Research Project Grants; Resources; Rest; Role; Science; Scientist; Self Management; Severities; Stress; Structure; Symptoms; Tai Ji; Techniques; Testing; Therapeutic; Time; Traditional Medicine; Training; Translational Research; United States National Institutes of Health; Universities; Veterans; Work; body-mind; career; central sensitization; chronic musculoskeletal pain; chronic pain; chronic pain patient; clinical practice; cognitive control; combat; comparative effectiveness; cost; cost effective; disability; effective therapy; evidence base; experience; experimental study; fibromyalgia patients; healing; health care service utilization; improved; innovation; interdisciplinary approach; lifestyle intervention; medical schools; multidisciplinary; neurobiological mechanism; next generation; novel; nutrition; opioid use; osteoarthritis pain; patient oriented; patient oriented research; professor; programs; public health relevance; response; social; sperm cell; symptom management; symptomatic improvement; theories; tool

MENTORING AND RESEARCH IN PATIENT-ORIENTED INTEGRATIVE MEDICINE The renewal Midcareer K24 Award is for Dr. Chenchen Wang to continue her mentoring of the next generation of physician-scientists and to contribute to patient-oriented Integrative Medicine research. Dr. Wang is Professor at Tufts University School of Medicine and Director of the Center for Complementary and Integrative Medicine and holds a strong record of research, publication, and mentoring. Her long-term goal is to advance the science of Integrative Medicine to promote health and healing. Her immediate goals are to obtain protected time to expand and strengthen her innovative, multi-method, and multidisciplinary translational research and mentoring programs for chronic disabling conditions. In the First Four Years of the K24, the PI has completed four major NIH-funded clinical trials studying comparative effectiveness of mind-body interventions for chronic musculoskeletal pain, developing integrative treatment approaches in military and veterans populations, and provided groundbreaking evidence on neurobiological and physiological responses to mind-body interventions. In this period, the PI published 61 articles, 8 as first author and 53 as senior author. The PI and her mentored team also received a new R01-like grant from the U.S. Department of Veterans Affairs to investigate the efficacy of a mind-body intervention for veterans suffering with Gulf War Illness. During the initial K24 period, she has been primary or co-primary mentor for 23 trainees with doctoral degrees. Her trainees authored 41 first-authored peer-reviewed publications and had 64 co-authorships. Ten of her trainees have their own NIH or other career grants. Dr. Wang’s multidisciplinary mentoring program, as well as her expertise on mind-body interventions, has been fully integrated into the research and teaching infrastructure of the Tufts Clinical and Translational Science Institute. With access to these outstanding resources and a long-recognized diverse training environment, her selected mentees will continue to obtain training in the rigorous scientific methodology, integrity, ethics, and grant applications necessary to stimulate high-quality, translational, patient-oriented research. The goal of this proposed K24 renewal is to build upon previous and current findings of the PI’s NIH-funded studies to: 1) expand and evaluate translational Integrative Medicine research for chronic disabling conditions in order to inform and benefit medical practice; 2) advance fundamental neuroscience and human biology research to understand the mechanisms of mind-body approaches, with the goal to improve chronic pain management; 3) identify critical unmet needs of novel effective therapies for managing symptoms; and 4) further strengthen the comprehensive interdisciplinary mentoring plan and extend opportunities to new scientists to guide future generations of Integrative Medicine researchers. This K24 renewal will therefore promote multidisciplinary patient-oriented research for the next generation of investigators in order to substantially advance the science on complementary and integrative medicine and contribute to the health, healthcare, and well-being for all.

以患者为中心的综合医学的指导和研究 更新的Midcareer K24奖是为了让王晨晨博士继续指导下一代 医师科学家并为以患者为导向的整合医学研究做出贡献。王博士是 塔夫茨大学医学院教授兼补充与整合中心主任 医学并在研究、出版和指导方面拥有良好的记录。她的长期目标是进步 促进健康和康复的综合医学科学。她的近期目标是获得保护 有时间扩大和加强她的创新、多方法、多学科转化研究和 针对慢性残疾状况的指导计划。 在 K24 的前四年中，PI 完成了 NIH 资助的四项主要临床试验 身心干预对慢性肌肉骨骼疼痛的比较有效性，发展综合性 军人和退伍军人群体的治疗方法，并提供了开创性的证据 对身心干预的神经生物学和生理反应。在此期间，PI 发表了 61 其中第一作者 8 篇，资深作者 53 篇。 PI 和她指导的团队还收到了一个类似 R01 的新产品 美国退伍军人事务部拨款用于调查身心干预的功效 患有海湾战争疾病的退伍军人。在最初的 K24 期间，她是小学或副小学 指导博士生23名。她的学员撰写了 41 篇第一作者的同行评审论文 出版物，并有 64 篇合著者。她的十名学员拥有自己的国家卫生研究院或其他职业补助金。博士。 王女士的多学科指导计划以及她在身心干预方面的专业知识得到了广泛认可。 完全融入塔夫茨临床和转化科学的研究和教学基础设施 研究所。凭借这些优秀的资源和长期认可的多元化培训环境，她 选定的受训者将继续接受严格的科学方法、诚信、道德和道德方面的培训 刺激高质量、转化性、以患者为导向的研究所需的拨款申请。 拟议的 K24 更新的目标是建立在 PI 的 NIH 资助的先前和当前发现的基础上 研究目的：1）扩大和评估慢性致残性疾病的转化整合医学研究 为医疗实践提供信息并使其受益； 2）推进基础神经科学和人类生物学 研究了解身心方法的机制，目标是改善慢性疼痛 管理; 3）确定治疗症状的新型有效疗法的未满足的关键需求；和 4）进一步加强全面的跨学科指导计划，并为新人提供机会 科学家指导未来几代综合医学研究人员。因此，这次 K24 更新将 促进下一代研究人员以患者为中心的多学科研究，以便 大幅推进补充和综合医学科学并为健康做出贡献， 医疗保健和所有人的福祉。