Tai Chi and Fibromyalgia

太极拳和纤维肌痛

• 批准号: 8187229
• 负责人: CHENCHEN WANG
• 金额: $ 71.29万
• 依托单位: TUFTS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8187229
• 关键词: Address; Adverse effects; Advocate; Aerobic; Aerobic Exercise; Affect; American; Area; Boston; Cardiovascular system; Chinese People; Chronic; Clinical; Clinical Trials; Clinical effectiveness; Communities; Diagnosis; Disabled Persons; Disease; Dose; Education; Effectiveness; Exercise; Fatigue; Fibromyalgia; Frequencies; Goals; Health; Healthcare Systems; Impairment; Individual; Institute of Medicine (U.S.); Insurance Carriers; Intervention; Life; Measures; Medical; Mental Health; Mind-Body Intervention; Muscle; Musculoskeletal Pain; Occupations; Outcome; Pain; Pain Disorder; Patients; Perception; Performance; Personal Satisfaction; Physical therapy exercises; Policy Maker; Population; Quality of life; Questionnaires; Randomized; Randomized Controlled Trials; Regimen; Research; Rheumatology; Schedule; Self Efficacy; Severities; Sleep; Sleep disturbances; Stretching; Symptoms; Syndrome; Tai Ji; Testing; Therapeutic; Time; United States; Work; blind; body-mind; chronic pain; college; combat; comparative effectiveness; conditioning; cost; disability payment; disabling disease; economic impact; effective intervention; effective therapy; effectiveness research; effectiveness trial; flexibility; follow-up; group intervention; health related quality of life; improved; innovation; meetings; metropolitan; muscle strength; novel; physical conditioning; primary outcome; programs; psychologic; psychosocial; satisfaction; secondary outcome; standard of care; tool

DESCRIPTION (provided by applicant): Fibromyalgia (FM) is a chronic musculoskeletal pain syndrome that causes substantial physical and psychological impairment and costs over $25 billion annually. Current pharmacological therapies may be expensive, cause serious adverse effects, and fail to effectively improve pain and function. Thus, finding new and effective non-pharmacological treatments for FM patients is urgently needed. Previous research has demonstrated that Tai Chi, a traditional Chinese mind-body exercise, can improve both physical and mental health for FM patients. However, no clinical trials have demonstrated its clinical effectiveness compared to standard aerobic exercise therapy, or determined its optimum dose (frequency or duration) as a treatment for FM. We therefore propose to conduct the first comparative effectiveness trial of Tai Chi vs. aerobic exercise (a recommended component of the current standard of care) and to evaluate effectiveness under different Tai Chi dosing schedules in a large FM population. We aim to (1) demonstrate that, compared to aerobic exercise, Tai Chi is a more effective intervention for managing the pain and improving the functional limitations that impact quality of life for FM patients, and 2) determine the optimal frequency and duration of a supervised Tai Chi intervention in relation to short and long-term effectiveness. To achieve this goal, we will conduct a single-blind, randomized controlled trial of Tai Chi vs. aerobic exercise in 216 patients who meet the American College of Rheumatology criteria for FM. Patients will be randomized to one of four Tai Chi intervention groups: 12 or 24 weeks of supervised Tai Chi given once or twice per week, or a supervised aerobic exercise control (2x/week for 24 weeks). All groups will have a 52-week follow-up. The primary outcome will be the FM Impact Questionnaire total score at 24 weeks. Secondary outcomes include the measures of widespread pain, functional performance, psychological functioning, self-efficacy, sleep quality, and quality of life at 12, 24, and 52 weeks. Successful completion of the proposed study will determine the ideal regimen of Tai Chi and demonstrate that Tai Chi can be a simple, effective, and durable treatment for this therapeutically challenging disorder. We believe that our work will convince the clinical community to implement Tai Chi as a first-line treatment for the millions of individuals with FM. PUBLIC HEALTH RELEVANCE: Fibromyalgia (FM) is the second most common rheumatologic condition in the United States and there are currently no satisfactory treatments. Innovative effective strategies are urgently needed. Tai Chi offers a novel and logistically feasible exercise regimen and a complementary mind-body approach to manage pain as well as enhance physical and mental health and wellness in patients with FM. Successful completion of the proposed study will demonstrate that Tai Chi is a simple, effective and durable treatment for FM. 1

纤维肌痛（FM）是一种慢性肌肉骨骼疼痛综合征，可导致严重的身体和心理损害，每年花费超过250亿美元。目前的药物治疗可能是昂贵的，导致严重的不良反应，并不能有效地改善疼痛和功能。因此，寻找新的和有效的非药物治疗FM患者是迫切需要的。以前的研究表明，太极拳，一种传统的中国身心运动，可以改善FM患者的身心健康。然而，没有临床试验证明其与标准有氧运动疗法相比的临床有效性，或确定其作为FM治疗的最佳剂量（频率或持续时间）。因此，我们建议进行太极拳与有氧运动（当前护理标准的推荐组成部分）的第一次比较有效性试验，并在大型FM人群中评估不同太极拳给药方案的有效性。我们的目标是（1）证明，与有氧运动相比，太极拳是一种更有效的干预措施，可以管理疼痛并改善影响FM患者生活质量的功能限制，以及（2）确定监督太极拳干预的最佳频率和持续时间与短期和长期有效性有关。为了实现这一目标，我们将在216名符合美国风湿病学会FM标准的患者中进行一项单盲、随机对照试验，比较太极拳与有氧运动。患者将被随机分配到四个太极干预组之一：每周一次或两次的12或24周监督太极，或监督有氧运动对照（每周2次，持续24周）。所有组将进行为期52周的随访。主要结局为第24周时FM影响问卷总分。次要结局包括广泛疼痛、功能表现、心理功能、自我效能、睡眠质量和12周、24周和52周的生活质量。成功完成拟议的研究将确定太极拳的理想方案，并证明太极拳可以是这种治疗上具有挑战性的疾病的简单，有效和持久的治疗方法。我们相信，我们的工作将说服临床社区将太极拳作为数百万FM患者的一线治疗。 公共卫生相关性：纤维肌痛（FM）是美国第二常见的风湿性疾病，目前还没有令人满意的治疗方法。迫切需要创新的有效战略。太极拳提供了一种新颖的和逻辑上可行的运动方案和一种互补的身心方法来管理疼痛，以及增强FM患者的身心健康和健康。成功完成拟议的研究将证明太极是一种简单，有效和持久的治疗FM。1