Morehouse School of Medicine SNRP

描述（由申请人提供）：莫尔豪斯医学院（MSM）是一所年轻而充满活力的机构，通过培训医学和科学专业人员，并通过重点发展基础和转化研究环境，致力于探索该机构所服务人群中高疾病负担疾病的机制，为服务不足的人群提供强大的服务使命。为了与RFA的意图和其内部战略计划保持一致，MSM神经科学研究所建议扩大和加强其研究项目，重点关注NINDS任务相关研究，并增加来自不同背景的学生对高级神经科学研究事业的学术准备。在本申请中，我们提出了三个探索性项目，重点是：(1)确定新的基因靶点以帮助治疗睡眠障碍（项目1，Pi的Paul和DeBruyne）。在这个项目中，Pi将结合一个成熟的范例，比较表型的遗传易处理的动物模型与强大的基因定位工具，以确定新的睡眠调节基因；（ii）了解酸敏感离子通道1a （ASICIa）介导的信号通路在神经元中的作用（项目2，熊皮）。在本提案中，PI将定义生理和病理生理条件下ascia介导的信号级联；（iii）联合治疗蛛网膜下腔出血后迟发性神经元退化的有效性（项目3，PI Namura）。该项目将测试甜菜碱（三甲基甘氨酸）和非诺贝特的组合可能是治疗这种神经系统疾病的潜在策略的假设。应用程序的另外两个目标是(i)到

DESCRIPTION (provided by applicant): Morehouse School of Medicine (MSM) is a young and dynamic institution with a strong mission of service to the underserved through the training of medical and scientific professionals and through the focused development of a basic and translational research environment dedicated to exploring mechanisms of disorders with high disease burden in populations served by the institution. In keeping with the intent of the RFA and consistent with its internal strategic plan, the MSM Neuroscience Institute proposes to augment and strengthen its research programs focused on NINDS mission related research and to increase the academic preparedness of students from diverse backgrounds for advanced Neuroscience research careers. In this application, we proposed three exploratory projects that focus on: (1) Identifying new genetic targets to help treat sleep disorders (Project 1, Pi's Paul and DeBruyne). In this project, the Pi's will combine a well-established paradigm of comparative phenotyping of a genetically tractable animal model with powerful genetic mapping tools to identify novel sleep-regulatory gene; (ii) Understanding the role of Acid Sensing Ion Chanel 1a (ASICIa) -mediated signaling pathways in neurons (Project 2, PI Xiong). In this proposal, the PI will define ASICIa-mediated signaling cascades in physiological- and pathophysiological conditions; and (iii) The effectiveness of a combination therapy against delayed neuronal deterioration after subarachnoid hemorrhage (Project 3, PI Namura). This project will test the hypothesis that the combination of betaine (trimethylglycine) and fenofibrate may be a potential strategy for treating this neurological disease. Two other objectives of the application are (i) to train and develop a competitive cadre of neuroscientists from underrepresented groups by providing tools to enhance the competiveness of Neuroscience Institute faculty; and (11) to provide training opportunities for graduate students and postdoctoral fellows and to expand the pool of undergraduates exposed to competitive Neuroscience research. To accomplish the above goals, we will provide effective administrative and scientific resource cores to facilitate the goals of this application.