Basic & Translational Neuroscience Research

基本的

• 批准号: 8277936
• 负责人: PETER RAYMOND MACLEISH
• 金额: $ 118.54万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8277936
• 关键词: Affect; Area; Biology; Bipolar Disorder; Brain; Cellular biology; Chronic Disease; Circadian Rhythm Sleep Disorders; Circadian Rhythms; Diagnostic tests; Disease; Environment; Funding; Goals; Grant; Head; Health; Image; In Vitro; Institutes; Jet Lag Syndrome; Knowledge; Lead; Lighting; Lithium; Maintenance; Medical Students; Methodology; Microscopy; Minority; Molecular; Molecular Biology; Mood Disorders; Morbidity - disease rate; Morehouse School of Medicine; Mus; Neurosciences; Neurosciences Research; Peripheral; Phase; Population; Program Research Project Grants; Rattus; Recruitment Activity; Request for Proposals; Research; Research Personnel; Research Project Grants; Schedule; Science; Series; Sleep; Sleep Architecture; Sleep Wake Cycle; Stroke; Students; Testing; Training; body system; career; circadian pacemaker; clinical practice; cost effective; men who have sex with men; mortality; neuroprotection; operation; programs; shift work; success; translational neuroscience

DESCRIPTION (provided by applicant): In this new application, the Morehouse School of Medicine Neuroscience Institute is requesting funds to consolidate a program in Circadian Rhythms and Sleep Disorders (CRSD) that was established within the last two years. The CRSD Program is headed by Dr. Gianluca Tosini, an established investigator in the field of circadian rhythms. The current proposal consists of projects from 2 recently-recruited young investigators (Drs. Davidson and Paul) and 1 previously-funded investigator (Dr. Fukuhara). All projects build on the impressive advances of our understanding of the molecular components of the master circadian pacemaker and the interrelationships with peripheral circadian oscillators. All three projects have strong translational components and have direct relevance to a number of disorders that disproportionately affect minority populations. Dr. Davidson's research program (Project # 1) will investigate the consequence of changing lighting schedules (as might occur as a result of shift-work and jet-lag) on the health of mice. Dr. Fukuhara's research program (Project # 2) is centered on the relationships between mood disorders and misalignment of circadian rhythms. Dr. Paul's research program (Project # 3) will investigate sleep in a series of genetically altered mice. Another program -The Neuroprotection, Neurorepair and Stroke Program - headed by Dr. Byron Ford, has 2 R01 holders, is not requesting funds, but will make intellectual contributions towards the maintenance of a vibrant research environment within the Neuroscience Institute. In addition to requesting funds for the three projects listed above, the proposal requests funds for an administrative core and two research cores - Cell and Molecular Biology Core and Imaging and Microscopy Core - that will, in a cost-effective manner, support the science within the projects. Finally, a Training and Knowledge Transfer Core is requesting funds to continue a highly-successful Summer Research Program for undergraduates and medical students and a seminar series to keep investigators abreast of research from leading investigators. Our goal is to increase the number of investigators at MSM who are conducting competitive research at the R01 level and the pool of students from under-represented populations who are pursuing a career in the field of Neuroscience.

描述（由申请人提供）： 在这项新的申请中，莫尔豪斯医学院神经科学研究所正在申请资金，以巩固在过去两年中建立的昼夜节律和睡眠障碍（CRSD）计划。CRSD计划由Gianluca Tosini博士领导，他是昼夜节律领域的知名研究者。目前的提案包括2名最近招募的年轻研究者（Davidson博士和Paul博士）和1名以前资助的研究者（Fukuhara博士）的项目。所有项目都建立在我们对主昼夜节律起搏器的分子组成以及与外周昼夜节律振荡器的相互关系的理解的令人印象深刻的进步之上。所有这三个项目都有很强的翻译组成部分，并与一些不成比例地影响少数群体的疾病直接相关。Davidson博士的研究计划（项目#1）将调查改变照明时间表（可能由于轮班工作和时差而发生）对小鼠健康的影响。福原爱博士的研究计划（项目#2）是集中在情绪障碍和昼夜节律失调之间的关系。保罗博士的研究计划（项目#3）将调查一系列基因改变小鼠的睡眠。另一个项目--神经保护、神经修复和中风项目--由拜伦福特博士领导，有2名R 01持有人，不要求资金，但将为维持神经科学研究所内充满活力的研究环境做出智力贡献。除了为上述三个项目申请资金外，该提案还为一个行政核心和两个研究核心-细胞和分子生物学核心以及成像和显微镜核心-申请资金，这些核心将以具有成本效益的方式支持项目内的科学。最后，一个培训和知识转移核心正在申请资金，以继续为本科生和医科学生提供非常成功的暑期研究计划，并举办一系列研讨会，以使研究人员了解领先研究人员的研究情况。 我们的目标是增加在MSM谁是在R 01水平进行竞争性研究的调查人员的数量和学生的代表性不足的人群谁是追求在神经科学领域的职业生涯池。

项目成果

Proteomic Analysis After Status Epilepticus Identifies UCHL1 as Protective Against Hippocampal Injury.

癫痫持续状态后的蛋白质组学分析确定 UCHL1 可预防海马损伤。

• DOI: 10.1007/s11064-017-2260-6
• 发表时间: 2017
• 期刊: Neurochemical research
• 影响因子: 4.4
• 作者: Reynolds,JamesP;Jimenez-Mateos,EvaM;Cao,Li;Bian,Fang;Alves,Mariana;Miller-Delaney,SuzanneF;Zhou,An;Henshall,DavidC
• 通讯作者: Henshall,DavidC