Basic & Translational Neuroscience Research

描述(由申请人提供)： 在这项新的申请中，莫尔豪斯医学院神经科学研究所正在申请资金，以巩固在过去两年内建立的昼夜节律和睡眠障碍(CRSD)项目。CRSD项目由吉安卢卡·托西尼博士领导，他是昼夜节律领域的知名研究员。目前的提议包括2名新近招聘的年轻调查员(Davidson博士和Paul博士)和1名以前获得资助的调查员(Fukuhara博士)的项目。所有项目都建立在我们对主要昼夜节律起搏器的分子组成以及与外围昼夜节律振荡器的相互关系的理解方面令人印象深刻的进步之上。所有这三个项目都有很强的翻译成分，并与一些对少数群体造成不成比例影响的疾病有直接关联。戴维森博士的研究计划(项目1)将调查改变照明时间表(如轮班工作和时差可能发生的结果)对小鼠健康的影响。福原博士的研究项目(项目2)集中在情绪障碍和昼夜节律失调之间的关系。保罗博士的研究项目(项目3)将调查一系列转基因小鼠的睡眠情况。由拜伦·福特博士领导的另一个项目--神经保护、神经修复和中风计划--有2名R01持有者，没有申请资金，但将为维持神经科学研究所内充满活力的研究环境做出智力贡献。除了为上述三个项目申请资金外，该提案还要求为一个行政核心和两个研究核心--细胞和分子生物学核心以及成像和显微镜核心--提供资金，这些核心将以具有成本效益的方式支持项目中的科学。最后，一个培训和知识转移核心正在申请资金，以继续为本科生和医学生开展一个非常成功的暑期研究计划，并举办一系列研讨会，让调查人员了解主要研究人员的研究情况。我们的目标是增加MSM在R01级别进行竞争性研究的研究人员的数量，以及在神经科学领域寻求职业生涯的来自代表性不足人群的学生池。

DESCRIPTION (provided by applicant): In this new application, the Morehouse School of Medicine Neuroscience Institute is requesting funds to consolidate a program in Circadian Rhythms and Sleep Disorders (CRSD) that was established within the last two years. The CRSD Program is headed by Dr. Gianluca Tosini, an established investigator in the field of circadian rhythms. The current proposal consists of projects from 2 recently-recruited young investigators (Drs. Davidson and Paul) and 1 previously-funded investigator (Dr. Fukuhara). All projects build on the impressive advances of our understanding of the molecular components of the master circadian pacemaker and the interrelationships with peripheral circadian oscillators. All three projects have strong translational components and have direct relevance to a number of disorders that disproportionately affect minority populations. Dr. Davidson's research program (Project # 1) will investigate the consequence of changing lighting schedules (as might occur as a result of shift-work and jet-lag) on the health of mice. Dr. Fukuhara's research program (Project # 2) is centered on the relationships between mood disorders and misalignment of circadian rhythms. Dr. Paul's research program (Project # 3) will investigate sleep in a series of genetically altered mice. Another program -The Neuroprotection, Neurorepair and Stroke Program - headed by Dr. Byron Ford, has 2 R01 holders, is not requesting funds, but will make intellectual contributions towards the maintenance of a vibrant research environment within the Neuroscience Institute. In addition to requesting funds for the three projects listed above, the proposal requests funds for an administrative core and two research cores - Cell and Molecular Biology Core and Imaging and Microscopy Core - that will, in a cost-effective manner, support the science within the projects. Finally, a Training and Knowledge Transfer Core is requesting funds to continue a highly-successful Summer Research Program for undergraduates and medical students and a seminar series to keep investigators abreast of research from leading investigators. Our goal is to increase the number of investigators at MSM who are conducting competitive research at the R01 level and the pool of students from under-represented populations who are pursuing a career in the field of Neuroscience.