Basic & Translational Neuroscience Research

描述（由申请人提供）： 在这份新申请中，莫尔豪斯医学院神经科学研究所正在申请资金，以巩固过去两年内建立的昼夜节律和睡眠障碍 (CRSD) 项目。 CRSD 项目由 Gianluca Tosini 博士领导，他是昼夜节律领域的知名研究者。当前的提案由 2 名最近招募的年轻研究人员（戴维森博士和保罗博士）和 1 名先前资助的研究人员（福原博士）的项目组成。所有项目都建立在我们对主昼夜节律起搏器的分子成分以及与外周昼夜节律振荡器的相互关系的理解的令人印象深刻的进步之上。所有三个项目都具有很强的转化成分，并且与对少数族裔人口造成不成比例影响的许多疾病有直接关系。戴维森博士的研究计划（项目＃1）将调查改变照明时间表（可能由于轮班工作和时差反应而发生）对小鼠健康的影响。福原博士的研究计划（项目＃2）集中于情绪障碍和昼夜节律失调之间的关系。 Paul 博士的研究计划（项目#3）将研究一系列基因改造小鼠的睡眠情况。另一个项目——神经保护、神经修复和中风项目——由 Byron Ford 博士领导，拥有 2 个 R01 持有者，不要求资金，但将为维持神经科学研究所内充满活力的研究环境做出智力贡献。除了为上述三个项目申请资金外，该提案还为一个行政核心和两个研究核心（细胞和分子生物学核心以及成像和显微镜核心）申请资金，这将以具有成本效益的方式支持项目内的科学。最后，培训和知识转移核心正在申请资金，以继续为本科生和医学生举办非常成功的夏季研究计划，并举办一系列研讨会，以使研究人员及时了解领先研究人员的研究成果。我们的目标是增加 MSM 进行 R01 级别竞争性研究的研究人员数量，以及来自代表性不足人群、在神经科学领域追求职业生涯的学生人数。

DESCRIPTION (provided by applicant): In this new application, the Morehouse School of Medicine Neuroscience Institute is requesting funds to consolidate a program in Circadian Rhythms and Sleep Disorders (CRSD) that was established within the last two years. The CRSD Program is headed by Dr. Gianluca Tosini, an established investigator in the field of circadian rhythms. The current proposal consists of projects from 2 recently-recruited young investigators (Drs. Davidson and Paul) and 1 previously-funded investigator (Dr. Fukuhara). All projects build on the impressive advances of our understanding of the molecular components of the master circadian pacemaker and the interrelationships with peripheral circadian oscillators. All three projects have strong translational components and have direct relevance to a number of disorders that disproportionately affect minority populations. Dr. Davidson's research program (Project # 1) will investigate the consequence of changing lighting schedules (as might occur as a result of shift-work and jet-lag) on the health of mice. Dr. Fukuhara's research program (Project # 2) is centered on the relationships between mood disorders and misalignment of circadian rhythms. Dr. Paul's research program (Project # 3) will investigate sleep in a series of genetically altered mice. Another program -The Neuroprotection, Neurorepair and Stroke Program - headed by Dr. Byron Ford, has 2 R01 holders, is not requesting funds, but will make intellectual contributions towards the maintenance of a vibrant research environment within the Neuroscience Institute. In addition to requesting funds for the three projects listed above, the proposal requests funds for an administrative core and two research cores - Cell and Molecular Biology Core and Imaging and Microscopy Core - that will, in a cost-effective manner, support the science within the projects. Finally, a Training and Knowledge Transfer Core is requesting funds to continue a highly-successful Summer Research Program for undergraduates and medical students and a seminar series to keep investigators abreast of research from leading investigators. Our goal is to increase the number of investigators at MSM who are conducting competitive research at the R01 level and the pool of students from under-represented populations who are pursuing a career in the field of Neuroscience.