Pathogenesis and Diagnosis of Multiple System Atrophy

多系统萎缩的发病机制和诊断

• 批准号: 8539085
• 负责人: Peter O'Brien
• 金额: $ 14.81万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8539085
• 关键词: Autopsy; Clinical Data; Collection; DNA; Data; Data Analyses; Data Collection; Databases; Diagnosis; Doctor of Medicine; Doctor of Philosophy; Experimental Models; Failure; Functional disorder; Housing; Mission; Multiple System Atrophy; Pathogenesis; Patients; Principal Investigator; Reporting; Research Personnel; Sampling; Statistical Data Interpretation; data management; member; programs; tool

Core B Data Core - Peter C. O'Brien, Ph.D., Principal Investigator The Data Core is responsible for the collection, entry, management, and analysis of the MSA database. Specifically, the Core will facilitate the collection of data, it assures the quality of the captured data, it manages the evolving database, including doing routine backups. It reports to the PI and the other investigators on the state of the database, it conducts the statistical analyses other data and archival of the database at the conclusion of the project. The Data Core will provide support for data management for the program project. In particular, the data core will provide statistical support for Project 1, Predictors of Rapid Progression in MSA, PI: Sid Gilman, M.D. Data Core members will also provide assistance with data analyses and/or compile analysis files of clinical data for the following projects: Project 4, Studies on Diagnosis, Pathophysiology, and Treatment of Autonomic Failure in MSA, PI: Phillip Low, M.D., and Project 3: Models and Experimental Treatment for MSA, PI: Eliezer Masliah, M.D.. Furthermore, the data base maintained by Core B will house information from Cores C (autopsy results of deceased MSA patients) and Core D (availability of samples and DNA).

核心B数据核心-Peter C.O‘Brien博士，首席调查员 数据核心负责MSA数据库的收集、录入、管理和分析。具体地说，核心将促进数据的收集，它确保捕获数据的质量，它管理不断发展的数据库，包括进行例行备份。它向PI和其他调查人员报告数据库的状态，并在项目结束时对数据库的其他数据进行统计分析和存档。 数据核心将为方案项目的数据管理提供支持。特别是，数据核心将为项目1，MSA快速进展的预测因素，PI：Sid Gilman，M.D.提供统计支持。数据核心成员还将为以下项目提供数据分析和/或汇编临床数据的分析文件：项目4，MSA中自主神经衰竭的诊断、病理生理学和治疗研究，PI：Phillip Low，M.D.和项目3：MSA的模型和实验治疗，PI：Eliezer Masliah，M.D.此外，核心B维护的数据库将储存来自核心C(已死MSA患者的尸检结果)和核心D(可获得样本和DNA)的信息。