Core E: Animal Models of Physiology Core

核心E：生理学核心动物模型

• 批准号: 8446548
• 负责人: MANAMI HARA
• 金额: $ 17.85万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-02-01 至 2018-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8446548
• 关键词: Animal Model; Bacterial Artificial Chromosomes; Bass; Caenorhabditis elegans; Cell Culture Techniques; Cellular biology; Collaborations; Consultations; DNA; DNA Fingerprinting; Development; Diabetes Mellitus; Diabetic mouse; Drosophila genus; Ensure; Equipment; Experimental Designs; Family suidae; Funding; Future; Gene Targeting; Generations; Genes; Germ-Line Mutation; Human; Image; Image Analysis; Islets of Langerhans; Islets of Langerhans Transplantation; Kidney; Knockout Mice; Leadership; Metabolic; Metabolism; Microinjections; Mission; Modeling; Mus; Pancreas; Pancreatectomy; Phenotype; Physiology; Play; Research; Research Personnel; Research Training; Resources; Role; Services; Streptozocin; Structure of beta Cell of islet; Study models; Technology; Training; Transgenes; Transgenic Mice; Transgenic Organisms; Zebrafish; capsule; embryonic stem cell; endocrine pancreas development; experimental analysis; human embryonic stem cell; islet; man; member; mouse model; repository; technology development; tool; web site

An Animal Models and Physiology Core has been a unit of the DRTC since 1991. It was initially established to assist investigators in the generation of genetically modified mice. The Core has continued to evolve during the past funding period and now includes Mouse Metabolic Phenotyping as a service. The Animal Model and Physiology Core provides to Center members via access to a wide array of resources, technology, equipment and services for the generation and study of genetically modified mice and other model organisms in diabetes-related research, consultation on experimental design and analysis, repositories (mouse and human ES cells, mouse models), technology development (large-scale analysis of pancreatic islets from mice to man) and opportunities for collaboration. Some services are widely used (e.g. generation of transgenic and knockout mice and metabolic phenotyping) whereas others less so (advice and training in human ES cells). Nonetheless, rather than discontinuing unique or very specialized but rarely used services, we still list them on the DRTC website since future needs of members cannot be predicted and the leadership believes strongly that including them allows members to consider all available technologies in planning their research. Drs. Manami Hara and Anita Chong will continue to serve as Director and Co-Director of this Core. They will also be assisted by Technical Directors for Transgenic/ES Cell Technology (Degenstein) and Mouse Metabolic Phenotyping (Ye). The Core will have an internal advisory panel comprised of investigators using model organisms for diabetes/metabolism-related research: mice (Bass, Bell and Nobrega), zebrafish (Prince), Drosophila (Kreitman) and C. elegans (Ruvinsky). This organization will ensure that Core services are at the forefront of model organism studies and responsive to the needs of DRTC members

自1991年以来，动物模型和生理学核心一直是DRTC的一个单位。它最初是为了帮助研究人员生产转基因小鼠而建立的。核心在过去的资助期间继续发展，现在包括小鼠代谢表型分析作为一项服务。动物模型和生理学核心为中心成员提供广泛的资源，技术，设备和服务，用于糖尿病相关研究中转基因小鼠和其他模式生物的生成和研究，实验设计和分析咨询，（小鼠和人类胚胎干细胞、小鼠模型）、技术开发（从小鼠到人类胰岛的大规模分析）以及合作机会。有些服务得到广泛使用（例如，转基因和基因敲除小鼠的产生以及代谢表型分析），而另一些服务则较少（人类胚胎干细胞的咨询和培训）。尽管如此，我们并没有停止独特或非常专业但很少使用的服务，而是仍然在DRTC网站上列出这些服务，因为无法预测成员的未来需求，而且领导层坚信，包括这些服务可以让成员在规划研究时考虑所有可用的技术。Manami Hara博士和Anita Chong博士将继续担任该核心的主任和联合主任。他们还将得到转基因/ES细胞技术（Degenstein）和小鼠代谢表型分析（Ye）技术总监的协助。核心将有一个内部顾问小组，由使用糖尿病/代谢相关研究的模式生物的研究人员组成：小鼠（Bass，Bell和Nobrega），斑马鱼（Prince），果蝇（Kreitman）和C。elegans（Ruvinsky）.该组织将确保核心服务处于模式生物研究的最前沿，并响应DRTC成员的需求