Health Disparities in Chronic Kidney Disease Mentoring Program

描述（由申请人提供）：慢性肾脏疾病（CKD）困扰着美国超过2600万人，并且众所周知，种族/民族少数群体不成比例地受到这种慢性疾病的影响。造成这一差异的因素很复杂，而且还没有完全弄清楚。尽管迫切需要在这一领域进行更多研究，但选择学术肾脏病学职业的学员数量正在减少。K24以患者为导向的研究中期研究者奖提供了一个独特的机制，以帮助现有的研究者吸引和留住有才华的新医生-科学家的职业生涯 病人导向的研究。这个K24的候选人是James Lash，医学博士，伊利诺伊大学芝加哥分校（UIC）的医学副教授。Lash博士的研究重点是CKD的流行病学，特别强调少数民族人群。作为一名以患者为导向的研究人员，他拥有丰富的经验，是两项NIDDK申办的研究的主要研究者：1）慢性肾功能不全队列（CRIC）研究和2）西班牙裔CRIC研究。这些研究以及其他几项多中心合作研究为学员提供了丰富的机会。拉什博士在指导年轻研究人员方面有着良好的记录，其中包括大量来自少数民族背景的研究人员。该奖项资助的新研究项目是Lash博士正在进行的工作的自然延伸，并将为学员提供额外的机会。它由两个项目组成，重点关注导致CKD成人和儿童差异的潜在因素：1）个人/社区社会经济地位，2）健康素养。这项拟议的研究利用了两项正在进行的大型队列研究（CRIC研究和儿童慢性肾脏病研究）的基础设施，因此，提供了一个独特的机会来检查儿童和成人CKD患者的这些因素。除了指导研究，学员将通过UIC K30临床研究培训计划参加教学培训，并获得UIC临床转化科学中心（CCTS），UIC公共卫生学院和UIC P60健康差异卓越中心提供的广泛资源和基础设施。这个K24奖将为Lash博士提供额外的时间和资源，以扩大他在促进我们对健康的理解方面的努力 在CKD和培训新的医生科学家成为独立的研究人员在肾脏疾病的研究差距。

DESCRIPTION (provided by applicant): Chronic kidney disease (CKD) afflicts more than 26 million individuals in the United States and it is well established that racial/ethnic minorities ae disproportionately affected by this chronic condition. The factors responsible for this disparity are complex and incompletely understood. Despite the critical need for more research in this area, decreasing number of trainees are choosing careers in academic nephrology. The K24 Midcareer Investigator Award in Patient- Oriented Research provides a unique mechanism to assist established investigators to attract and retain talented new physician-scientists to careers in patient-oriented research. The candidate for this K24 is James Lash, MD, an Associate Professor of Medicine at the University of Illinois at Chicago (UIC). Dr. Lash's research focuses on the epidemiology of CKD with a particular emphasis on minority populations. He has considerable experience as a patient- oriented researcher and is the Principal Investigator for two NIDDK-sponsored studies: 1) the Chronic Renal Insufficiency Cohort (CRIC) Study and 2) the Hispanic CRIC Study. These studies, as well as several other multicenter collaborative studies, provide a wealth of opportunities for trainees. Dr. Lash has developed a solid track record for mentoring young investigators, including a significant number from minority backgrounds. The new research program funded by this award is a natural extension of Dr. Lash's ongoing work and will provide additional opportunities for trainees. It consists of two projects which focus on potential factors contributing to disparities in adults and children with CKD: 1) individual/neighborhood socioeconomic status, and 2) health literacy. This proposed research leverages the infrastructure of two large ongoing cohort studies (the CRIC Study and Chronic Kidney Disease in Children Study) and therefore, provides a unique opportunity to examine these factors in both children and adults with CKD. In addition to mentored research, trainees will participate in didactic training through the UIC K30 Clinical Research Training Program and have access to the extensive resources and infrastructure provided by the UIC Center for Clinical Translational Science (CCTS), the UIC School of Public Health, and the UIC P60 Center for Excellence in Health Disparities. This K24 award will provide Dr. Lash with the additional time and resources to amplify his efforts in contributing to our understanding of health disparities in CKD and in training new physician scientists to become independent investigators in kidney disease research.