University of Illinois at Chicago KPMP CKD Recruitment Site

慢性肾脏疾病(CKD)是美国一个主要的公共卫生问题，影响着3700万人 这对美国人和少数族裔人口造成了不成比例的负担。个性化研究的新进展 CKD患者的药物治疗方法落后于其他领域的进步。当前的方法是 对CKD进行分类并不能提供对有助于 疾病的异质性。为了解决这一差距，NIDDK建立了肾脏精准医学项目 (KPMP)在2016年的总体目标是使用肾脏活检的深分子表型，以及 纵向临床表型数据以开发新的疾病本体论和肾脏疾病的治疗方法。这 伊利诺伊大学芝加哥分校(UIC)KPMP CKD招生网站的提案汇集了不同的 由经验丰富的研究人员组成的多学科团队，具有肾脏病、肾脏病理、介入治疗等方面的专业知识 放射学、生物伦理学、健康的社会决定因素和生物统计学。我们的团队在以下方面有成功的记录 在长期研究中招募和保留大量和多样化的CKD患者。这项建议 有三个首要目标：1)利用我们成熟和成功的招聘战略，招募100名 参与者(50%非西班牙裔黑人，30%西班牙裔)来自伊利诺伊大学健康科学系统和 一个大型附属的联邦合格健康中心，接受高质量的研究性肾活检，符合 达到最高的伦理、研究和临床标准；2)利用UIC慢性肾脏的基础设施 不足队列(CRIC)研究临床中心招募50名符合条件的CRIC参与者参加KPMP，提供 这是一个前所未有的机会，可以将来自这个表型深刻的队列的数据与KPMP肾脏活检联系起来 措施；以及3)对社区一级的社会决定因素措施进行系统评估 这将推动KPMP的总体使命，更好地确定疾病亚群的特征。我们会 使用已建立的基于电子健康记录的实时报告系统来识别符合条件的个人 这两个医疗保健系统，然后让潜在的参与者参与公开讨论风险和 研究性肾活检的好处。此外，我们将利用以患者为中心的策略来保持长期的 在当地社区咨询的指导下，延长患者参与度并实现高保留率 由主要利益相关者(即患者、看护人和初级保健提供者)组成的委员会。利用我们的 与NIDDK U01合作项目的专业知识和经验，我们将快速有效地 执行KPMP协议，与财团合作，并将做出实质性贡献 为KPMP开发基于精确医学的治疗方法的长期科学使命 肾脏疾病。

Chronic kidney disease (CKD) is a major public health problem in the United States that affects 37 million Americans and disproportionately burdens racial and ethnic minority populations. Advances in personalized medicine approaches for patients with CKD lag behind advances in other fields. Current approaches to classifying CKD do not provide granular insight into the underlying mechanisms that contribute to the heterogeneity of the disease. To address this gap, NIDDK established the Kidney Precision Medicine Project (KPMP) in 2016 with the overarching goal of using deep molecular phenotypes of kidney biopsies, along with longitudinal clinical phenotypic data to develop new disease ontologies and treatments for kidney disease. This proposal for a University of Illinois at Chicago (UIC) KPMP CKD Recruitment Site brings together a diverse multidisciplinary team of experienced investigators with expertise in nephrology, renal pathology, interventional radiology, bioethics, social determinants of health, and biostatistics. Our team has a successful track record in recruiting and retaining large and diverse populations of patients with CKD in long-term studies. This proposal has three overarching goals: 1) Utilize our well-established and successful recruitment strategies to enroll 100 participants (50% non-Hispanic Black, 30% Hispanic) from the University of Illinois Health Science System and a large affiliated federally qualified health center to undergo high-quality research kidney biopsies, conforming to the highest ethical, research and clinical standards; 2) Leverage the infrastructure of the UIC Chronic Renal Insufficiency Cohort (CRIC) Study Clinical Center to enroll 50 eligible CRIC participants into KPMP, providing an unprecedented opportunity to link data from this deeply phenotyped cohort with KPMP kidney biopsy measures; and 3) Implement a systematic assessment of neighborhood-level measures of social determinants of health which will advance the overall mission of KPMP to better characterize disease subgroups. We will use an established real-time electronic health record-based reporting system to identify eligible individuals in the two health care systems and then engage potential participants in an open discussion of the risks and benefits of a research kidney biopsy. Additionally, we will utilize patient-centered strategies to maintain long- term patient engagement and achieve high rates of retention with the guidance of a local Community Advisory Board composed of key stakeholders (i.e., patients, a caretaker, and a primary care provider). Leveraging our expertise and experience working with NIDDK U01 cooperative projects, we will rapidly and effectively implement the KPMP protocol, work collaboratively with the consortium, and will make substantial contributions to the long-term scientific mission of KPMP to develop precision medicine-based approaches for treating kidney disease.