University of Illinois at Chicago KPMP CKD Recruitment Site

慢性肾脏疾病（CKD）是美国的一个主要公共卫生问题，影响3700万人 美国人和不成比例的负担种族和少数民族人口。个性化的进展 CKD患者的药物治疗方法落后于其他领域的进展。的当前方法 分类CKD并不能提供对导致CKD的潜在机制的详细了解。 疾病的异质性。为了解决这一差距，NIDDK建立了肾脏精准医学项目 （KPMP）在2016年的首要目标是使用肾脏活检的深层分子表型，沿着 纵向临床表型数据，以开发新的疾病本体和肾脏疾病的治疗。这 伊利诺伊大学芝加哥分校（UIC）KPMP CKD招聘网站的提案汇集了多样化的 由经验丰富的研究者组成的多学科团队，具有肾脏病学、肾脏病理学、介入性 放射学、生物伦理学、健康的社会决定因素和生物统计学。我们的团队在以下方面有着成功的记录： 在长期研究中招募和保留大量不同的CKD患者人群。这项建议 有三个首要目标：1）利用我们完善和成功的招聘策略，招收100名 来自伊利诺伊大学健康科学系统的参与者（50%非西班牙裔黑人，30%西班牙裔）， 一家大型附属联邦合格健康中心进行高质量的研究肾脏活检，符合 符合最高的伦理、研究和临床标准; 2）充分利用UIC慢性肾功能衰竭中心的基础设施， 功能不全队列（CRIC）研究临床中心招募50名合格的CRIC参与者进入KPMP，提供 这是一个前所未有的机会，可以将来自这个深度表型队列的数据与KPMP肾活检联系起来。 3）对社区一级的社会决定因素措施进行系统评估 这将推进KPMP的总体使命，以更好地表征疾病亚组。我们将 使用已建立的基于电子健康记录的实时报告系统， 两个医疗保健系统，然后让潜在的参与者公开讨论风险， 肾活检的好处此外，我们将利用以病人为中心的战略，以保持长期的， 长期患者参与，并在当地社区咨询的指导下实现高保留率 由主要利益攸关方组成的董事会（即，患者、护理人员和初级护理提供者）。利用我们 专业知识和经验与NIDDK U 01合作项目，我们将迅速，有效地 实施KPMP协议，与联合体合作，并将做出实质性贡献 KPMP的长期科学使命是开发基于精确医学的治疗方法， 肾病

Chronic kidney disease (CKD) is a major public health problem in the United States that affects 37 million Americans and disproportionately burdens racial and ethnic minority populations. Advances in personalized medicine approaches for patients with CKD lag behind advances in other fields. Current approaches to classifying CKD do not provide granular insight into the underlying mechanisms that contribute to the heterogeneity of the disease. To address this gap, NIDDK established the Kidney Precision Medicine Project (KPMP) in 2016 with the overarching goal of using deep molecular phenotypes of kidney biopsies, along with longitudinal clinical phenotypic data to develop new disease ontologies and treatments for kidney disease. This proposal for a University of Illinois at Chicago (UIC) KPMP CKD Recruitment Site brings together a diverse multidisciplinary team of experienced investigators with expertise in nephrology, renal pathology, interventional radiology, bioethics, social determinants of health, and biostatistics. Our team has a successful track record in recruiting and retaining large and diverse populations of patients with CKD in long-term studies. This proposal has three overarching goals: 1) Utilize our well-established and successful recruitment strategies to enroll 100 participants (50% non-Hispanic Black, 30% Hispanic) from the University of Illinois Health Science System and a large affiliated federally qualified health center to undergo high-quality research kidney biopsies, conforming to the highest ethical, research and clinical standards; 2) Leverage the infrastructure of the UIC Chronic Renal Insufficiency Cohort (CRIC) Study Clinical Center to enroll 50 eligible CRIC participants into KPMP, providing an unprecedented opportunity to link data from this deeply phenotyped cohort with KPMP kidney biopsy measures; and 3) Implement a systematic assessment of neighborhood-level measures of social determinants of health which will advance the overall mission of KPMP to better characterize disease subgroups. We will use an established real-time electronic health record-based reporting system to identify eligible individuals in the two health care systems and then engage potential participants in an open discussion of the risks and benefits of a research kidney biopsy. Additionally, we will utilize patient-centered strategies to maintain long- term patient engagement and achieve high rates of retention with the guidance of a local Community Advisory Board composed of key stakeholders (i.e., patients, a caretaker, and a primary care provider). Leveraging our expertise and experience working with NIDDK U01 cooperative projects, we will rapidly and effectively implement the KPMP protocol, work collaboratively with the consortium, and will make substantial contributions to the long-term scientific mission of KPMP to develop precision medicine-based approaches for treating kidney disease.