Health Disparities in Chronic Kidney Disease Mentoring Program

项目摘要/摘要 以患者为中心的研究中K24职业生涯中期研究人员奖的竞争性续展申请者 詹姆斯·拉什是伊利诺伊大学芝加哥分校(UIC)的医学教授。在最初的四场比赛中 多年来，在该奖项的支持下，拉什博士在指导和研究效率方面有着良好的记录。 在此期间，他作为导师的工作效率显著提高，这一点在25名学员领导下得到了反映 手稿，四个K23奖和一个多样性副刊，两个学术推广 教职员工，以及另外两名提议的提拔。值得注意的是，超过一半的拉什博士的实习生 代表不足的少数族裔。拉什博士的研究重点是慢性肾脏疾病的流行病学 (CKD)，特别重视少数群体。作为一个病人，他有相当多的经验- 面向研究人员，是NIH赞助的几项研究的首席研究员：1)慢性肾脏 不足队列(CRIC)研究UIC临床中心，2)西班牙裔CRIC研究，以及3)UIC PI 收缩压干预试验(Sprint)。此外，在资助期间，他的研究 随着他成为Fogarty国际中心赞助的墨西哥的PI，他的投资组合进一步扩大 总部设在墨西哥城的CRIC研究，NHLBI资助的西班牙裔社区健康研究/研究 拉丁裔芝加哥田径中心，T32项目副主任，专注于 少数族裔人口。这个综合性的研究项目为他的学员提供了丰富的机会。 这次K24更新的拟议新研究计划的总体目标是评估 两种潜在可改变的健康行为(久坐行为和睡眠)对健康结局的影响 慢性肾脏病患者。这项研究将利用拉什博士在大型正在进行的观察性研究中的领导作用 具有相当多的种族/少数民族代表性。此外，研究计划还将包括一项 试点干预的重点是减少慢性肾脏病成人的久坐行为和改善睡眠质量。在……里面 除了将重点放在有意义的领域之外，拟议的研究还将为学员提供丰富的 CKD中以患者为中心的研究机会。学员还将参加教学培训，通过 公共卫生学院，并可利用中心提供的广泛资源和基础设施 临床转化科学奖。续签K24奖项将为拉什博士提供受保护的时间 和资源，继续扩大他成功的研究计划，并继续提供富有成效的 指导新的内科科学家发展成为独立调查人员所需的技能 肾脏疾病研究。

Project Summary/Abstract The applicant for this competing renewal of a K24 Midcareer Investigator Award in Patient-Oriented Research is James Lash, MD, a Professor of Medicine at the University of Illinois at Chicago (UIC). During the initial four years of support by this award, Dr. Lash has had a strong record of mentorship and research productivity. During this time, his productivity as a mentor has increased significantly as reflected by 25 trainee-led manuscripts, the receipt of four K23 awards and one Diversity Supplement, the academic promotion of two faculty members, and the proposed promotion of two others. Of note, over one-half of Dr. Lash's trainees are underrepresented minorities. Dr. Lash's research focuses on the epidemiology of chronic kidney disease (CKD) with a particular emphasis on minority populations. He has considerable experience as a patient- oriented researcher and is the Principal Investigator for several NIH-sponsored studies: 1) the Chronic Renal Insufficiency Cohort (CRIC) Study UIC Clinical Center, 2) the Hispanic CRIC Study, and 3) the UIC PI for the Systolic Blood Pressure Intervention Trial (SPRINT). In addition, during the funding period his research portfolio has further expanded with him becoming PI for the Fogarty International Center-sponsored Mexico CRIC Study based in Mexico City, Co-PI for the NHLBI-funded Hispanic Community Health Study/Study of Latinos Chicago Field Center, and Associate Director for a T32 program focused on health disparities in minority populations. This comprehensive research program provides a wealth of opportunities for his trainees. The overarching objective of the proposed new research program for this K24 renewal is to evaluate the impact of two potentially modifiable health behaviors (sedentary behavior and sleep) on health outcomes in patients with CKD. This research will leverage Dr. Lash's leadership role in large ongoing observational studies with substantial representation of racial/ethnic minorities. In addition, the research program will also include a pilot intervention focused on reducing sedentary behavior and improving sleep quality in adults with CKD. In addition to its focus on areas of significance, the proposed research will provide trainees with a rich range of opportunities in patient-oriented research in CKD. Trainees will also participate in didactic training through the School of Public Health and have access to the extensive resources and infrastructure provided by the Center for Clinical Translational Science. The renewal of this K24 award will provide Dr. Lash with the protected time and resources to continue to expand his successful research program and continue to provide productive mentorship of new physician scientists to develop the skills needed to become independent investigators in kidney disease research.