Health Disparities in Chronic Kidney Disease Mentoring Program

项目概要/摘要 K24 职业生涯中期研究者奖以患者为导向的研究的竞争续展申请人 James Lash 博士是伊利诺伊大学芝加哥分校 (UIC) 的医学教授。在最初的四场比赛中 在该奖项多年的支持下，Lash 博士在指导和研究生产力方面拥有良好的记录。 在此期间，他作为导师的生产力显着提高，这从 25 名受训者领导的项目中可以看出。 手稿，获得四项 K23 奖项和一项多样性补充奖，两项学术晋升 教职人员，以及提议晋升的另外两人。值得注意的是，拉什博士一半以上的学员是 代表性不足的少数群体。 Lash 博士的研究重点是慢性肾病的流行病学 （CKD），特别强调少数群体。作为一名患者，他拥有丰富的经验—— 定向研究人员，并且是 NIH 资助的多项研究的首席研究员：1) 慢性肾病 不足队列 (CRIC) 研究 UIC 临床中心，2) 西班牙裔 CRIC 研究，以及 3) UIC PI 收缩压干预试验（SPRINT）。此外，在资助期间，他的研究 随着他成为福格蒂国际中心资助的墨西哥的 PI，投资组合进一步扩大 CRIC 研究总部位于墨西哥城，是 NHLBI 资助的西班牙裔社区健康研究/研究的联合负责人 拉丁裔芝加哥现场中心，T32 项目副主任，专注于健康差异问题 少数民族人口。这个综合性的研究项目为他的学员提供了丰富的机会。 K24 更新拟议的新研究计划的总体目标是评估 两种潜在可改变的健康行为（久坐行为和睡眠）对健康结果的影响 慢性肾病患者。这项研究将利用拉什博士在正在进行的大型观察性研究中的领导作用 少数族裔/族裔具有相当大的代表性。此外，该研究计划还将包括 试点干预的重点是减少慢性肾病成人的久坐行为和改善睡眠质量。在 除了重点关注重要领域外，拟议的研究还将为学员提供丰富的知识 以患者为导向的 CKD 研究机会。学员还将通过以下方式参加教学培训： 公共卫生学院，并可以使用该中心提供的广泛资源和基础设施 临床转化科学。 K24 奖项的续签将为 Lash 博士提供受保护的时间 和资源来继续扩大他成功的研究计划并继续提供富有成效的成果 指导新的医师科学家，培养成为独立研究者所需的技能 肾脏疾病研究。

Project Summary/Abstract The applicant for this competing renewal of a K24 Midcareer Investigator Award in Patient-Oriented Research is James Lash, MD, a Professor of Medicine at the University of Illinois at Chicago (UIC). During the initial four years of support by this award, Dr. Lash has had a strong record of mentorship and research productivity. During this time, his productivity as a mentor has increased significantly as reflected by 25 trainee-led manuscripts, the receipt of four K23 awards and one Diversity Supplement, the academic promotion of two faculty members, and the proposed promotion of two others. Of note, over one-half of Dr. Lash's trainees are underrepresented minorities. Dr. Lash's research focuses on the epidemiology of chronic kidney disease (CKD) with a particular emphasis on minority populations. He has considerable experience as a patient- oriented researcher and is the Principal Investigator for several NIH-sponsored studies: 1) the Chronic Renal Insufficiency Cohort (CRIC) Study UIC Clinical Center, 2) the Hispanic CRIC Study, and 3) the UIC PI for the Systolic Blood Pressure Intervention Trial (SPRINT). In addition, during the funding period his research portfolio has further expanded with him becoming PI for the Fogarty International Center-sponsored Mexico CRIC Study based in Mexico City, Co-PI for the NHLBI-funded Hispanic Community Health Study/Study of Latinos Chicago Field Center, and Associate Director for a T32 program focused on health disparities in minority populations. This comprehensive research program provides a wealth of opportunities for his trainees. The overarching objective of the proposed new research program for this K24 renewal is to evaluate the impact of two potentially modifiable health behaviors (sedentary behavior and sleep) on health outcomes in patients with CKD. This research will leverage Dr. Lash's leadership role in large ongoing observational studies with substantial representation of racial/ethnic minorities. In addition, the research program will also include a pilot intervention focused on reducing sedentary behavior and improving sleep quality in adults with CKD. In addition to its focus on areas of significance, the proposed research will provide trainees with a rich range of opportunities in patient-oriented research in CKD. Trainees will also participate in didactic training through the School of Public Health and have access to the extensive resources and infrastructure provided by the Center for Clinical Translational Science. The renewal of this K24 award will provide Dr. Lash with the protected time and resources to continue to expand his successful research program and continue to provide productive mentorship of new physician scientists to develop the skills needed to become independent investigators in kidney disease research.