Health Disparities in Chronic Kidney Disease Mentoring Program

慢性肾脏病指导计划中的健康差异

• 批准号: 10470886
• 负责人: JAMES P. LASH
• 金额: $ 19.35万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-10 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10470886
• 关键词: Adult; Affect; Albuminuria; Area; Award; Chicago; Chronic; Chronic Kidney Failure; Chronic Kidney Insufficiency; Cities; Cohort Studies; Development; Enrollment; Epidemiology; Faculty; Fogarty International Center; Fostering; Funding; Future; Goals; Health; Health behavior; Hispanic; Hispanic Community Health Study/Study of Latinos; Illinois; Individual; Infrastructure; Institutional support resources; Intervention; Intervention Trial; K-Series Research Career Programs; Kidney Diseases; Leadership; Manuscripts; Measures; Medicine; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Mexican; Mexico; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Minority; Minority Groups; National Heart, Lung, and Blood Institute; Nephrology; Observational Study; Outcome; Patients; Physicians; Principal Investigator; Productivity; Public Health Schools; Publications; Renal function; Research; Research Methodology; Research Personnel; Research Proposals; Resources; Risk; Role; Scientist; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Sleep disturbances; Time; Training; Translational Research; Underrepresented Minority; United States; United States National Institutes of Health; Universities; base; blood pressure intervention; career; clinical center; clinical practice; cohort; design; epidemiology study; ethnic minority; experience; health disparity; improved; innovation; member; patient oriented; patient oriented research; pilot trial; population based; professor; programs; prospective; racial and ethnic; randomized trial; sedentary; sedentary lifestyle; skills; sleep quality; therapy development

Project Summary/Abstract The applicant for this competing renewal of a K24 Midcareer Investigator Award in Patient-Oriented Research is James Lash, MD, a Professor of Medicine at the University of Illinois at Chicago (UIC). During the initial four years of support by this award, Dr. Lash has had a strong record of mentorship and research productivity. During this time, his productivity as a mentor has increased significantly as reflected by 25 trainee-led manuscripts, the receipt of four K23 awards and one Diversity Supplement, the academic promotion of two faculty members, and the proposed promotion of two others. Of note, over one-half of Dr. Lash's trainees are underrepresented minorities. Dr. Lash's research focuses on the epidemiology of chronic kidney disease (CKD) with a particular emphasis on minority populations. He has considerable experience as a patient- oriented researcher and is the Principal Investigator for several NIH-sponsored studies: 1) the Chronic Renal Insufficiency Cohort (CRIC) Study UIC Clinical Center, 2) the Hispanic CRIC Study, and 3) the UIC PI for the Systolic Blood Pressure Intervention Trial (SPRINT). In addition, during the funding period his research portfolio has further expanded with him becoming PI for the Fogarty International Center-sponsored Mexico CRIC Study based in Mexico City, Co-PI for the NHLBI-funded Hispanic Community Health Study/Study of Latinos Chicago Field Center, and Associate Director for a T32 program focused on health disparities in minority populations. This comprehensive research program provides a wealth of opportunities for his trainees. The overarching objective of the proposed new research program for this K24 renewal is to evaluate the impact of two potentially modifiable health behaviors (sedentary behavior and sleep) on health outcomes in patients with CKD. This research will leverage Dr. Lash's leadership role in large ongoing observational studies with substantial representation of racial/ethnic minorities. In addition, the research program will also include a pilot intervention focused on reducing sedentary behavior and improving sleep quality in adults with CKD. In addition to its focus on areas of significance, the proposed research will provide trainees with a rich range of opportunities in patient-oriented research in CKD. Trainees will also participate in didactic training through the School of Public Health and have access to the extensive resources and infrastructure provided by the Center for Clinical Translational Science. The renewal of this K24 award will provide Dr. Lash with the protected time and resources to continue to expand his successful research program and continue to provide productive mentorship of new physician scientists to develop the skills needed to become independent investigators in kidney disease research.

项目总结/摘要 K24中期职业研究者奖（Midcareer Investigator Award in Patient-Oriented Research）的竞争性续期申请人 是James Lash，医学博士，伊利诺伊大学芝加哥分校（UIC）的医学教授。在最初的四年里， 在该奖项多年的支持下，Lash博士在指导和研究生产力方面有着良好的记录。 在此期间，他作为导师的工作效率显著提高，25名受训者领导的 手稿，收到四个K23奖和一个多样性补充，两个学术推广 教师，并提出了两个其他人的晋升。值得注意的是，超过一半的赖什医生的学员 代表性不足的少数民族。拉什博士的研究重点是慢性肾脏疾病的流行病学 (CKD)特别强调少数民族人口。他对病人很有经验- 他是一位面向研究者的研究人员，是NIH赞助的几项研究的主要研究者：1）慢性肾功能衰竭 功能不全队列（CRIC）研究UIC临床中心，2）西班牙裔CRIC研究，和3）UIC PI 收缩压干预试验（SPRINT）。此外，在资助期间，他的研究 随着他成为Fogarty国际中心赞助的墨西哥PI，投资组合进一步扩大 位于墨西哥城的CRIC研究，NHLBI资助的西班牙裔社区健康研究/ 拉丁美洲芝加哥现场中心，和副主任的T32计划的重点是健康差距， 少数民族人口。这个综合性的研究计划为他的学员提供了丰富的机会。 本次K24更新的拟议新研究计划的总体目标是评估 两种可能改变的健康行为（久坐行为和睡眠）对健康结果的影响 CKD患者。这项研究将利用博士的领导作用，在大型正在进行的观察性研究 少数种族/族裔占很大比例。此外，该研究计划还将包括一个 试点干预的重点是减少慢性肾脏病成人的久坐行为和改善睡眠质量。在 除了关注重要领域外，拟议的研究还将为学员提供丰富的 在CKD患者为导向的研究机会。学员还将参加教学培训， 公共卫生学院，并有机会获得该中心提供的广泛的资源和基础设施 临床转化科学K24奖项的更新将为Lash博士提供受保护的时间 和资源，继续扩大他成功的研究计划，并继续提供富有成效的 指导新的医生科学家，以发展成为独立研究者所需的技能， 肾病研究。

项目成果

Sleep-Disordered Breathing and Prevalent Albuminuria in Hispanics/Latinos.

• DOI: 10.1016/j.ekir.2018.06.005
• 发表时间: 2018-11
• 期刊: Kidney international reports
• 影响因子: 6
• 作者: Ricardo AC;Chen J;Singh M;Heiss G;Raij L;Ramos A;Redline S;Rosas SE;Shah N;Sotres-Alvarez D;Zee P;Daviglus M;Lash JP
• 通讯作者: Lash JP

Association of Sleep Duration, Symptoms, and Disorders with Mortality in Adults with Chronic Kidney Disease.

• DOI: 10.1016/j.ekir.2017.05.002
• 发表时间: 2017-09
• 期刊: Kidney international reports
• 影响因子: 6
• 作者: Ricardo AC;Goh V;Chen J;Cedillo-Couvert E;Kapella M;Prasad B;Parvathaneni S;Knutson K;Lash JP
• 通讯作者: Lash JP

The National Kidney Foundation of Illinois KidneyMobile: a mobile resource for community based screenings of chronic kidney disease and its risk factors.

• DOI: 10.1186/s12882-018-1079-y
• 发表时间: 2018-10-25
• 期刊: BMC nephrology
• 影响因子: 2.3
• 作者: Lederer S;Ruggiero L;Sisen NM;Lepain N;O'Connor KG;Wang Y;Chen J;Lash JP;Fischer MJ
• 通讯作者: Fischer MJ

Kidney ultrasound findings according to kidney function in sickle cell anemia.

根据镰状细胞性贫血肾功能的肾脏超声检查结果。

• DOI: 10.1002/ajh.25602
• 发表时间: 2019
• 期刊: American journal of hematology
• 影响因子: 12.8
• 作者: Patel,Rishi;Kang,Sandra;Valeshabad,AliKord;Shah,BinalN;Han,Jin;Gowhari,Michel;Molokie,RobertE;Xie,Karen;Lash,JamesP;Gordeuk,VictorR;Saraf,SantoshL
• 通讯作者: Saraf,SantoshL

Illicit drug use, hypertension, and chronic kidney disease in the US adult population.

• DOI: 10.1016/j.trsl.2012.05.008
• 发表时间: 2012-12
• 期刊: Translational research : the journal of laboratory and clinical medicine
• 作者: Akkina SK;Ricardo AC;Patel A;Das A;Bazzano LA;Brecklin C;Fischer MJ;Lash JP
• 通讯作者: Lash JP