Neural Correlates of Food Reward in American Indian Women

美国印第安女性食物奖励的神经相关性

• 批准号: 8534859
• 负责人: Tiffany Rae Beckman
• 金额: $ 18.03万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8534859
• 关键词: Accounting; Adult; American; American Indians; Appetite Regulation; Area; Behavioral; Biometry; Brain; Brain imaging; Calories; Clinical Research; Clinical Sciences; Cognitive; Consumption; Counseling; Cross-Over Studies; Cues; Data; Data Analyses; Diabetes Mellitus; Diet; Dietary Intervention; Disease; Double-Blind Method; Eating; Education; Endocrinologist; Endocrinology; Energy Intake; Energy Metabolism; Environment; Epidemic; Food; Functional Magnetic Resonance Imaging; Genetic; Goals; Healthcare; Homeostasis; Human; Hyperphagia; Image; Impulsivity; Individual; Individual Differences; Institutes; Interdisciplinary Study; K-Series Research Career Programs; Knowledge acquisition; Lead; Literature; Magnetic Resonance Imaging; Measures; Mediating; Mentored Patient-Oriented Research Career Development Award; Mentors; Minnesota; Naltrexone; Narcotic Antagonists; Neuroanatomy; Neurobiology; Neurons; Neuropsychology; Neurosecretory Systems; Obesity; Opioid; Pathway interactions; Patients; Pattern; Perception; Persons; Pharmaceutical Preparations; Placebo Control; Placebos; Population; Prevention; Process; Public Health; Randomized; Regulation; Relative (related person); Research; Research Activity; Research Design; Research Methodology; Research Personnel; Resources; Rewards; Role; Scientist; Sex Characteristics; Testing; Time; Training; Training Activity; Translational Research; Universities; Visual; Woman; Work; addiction; career; computational neuroscience; data acquisition; design; effective therapy; experience; fast food; health disparity; interest; motivational enhancement therapy; neuroimaging; neuroregulation; obesity treatment; prevent; programs; relating to nervous system; response; reward processing; skills; treatment strategy; visual stimulus

DESCRIPTION (provided by applicant): This K23 award will allow Dr. Beckman, the first American Indian (AI) adult endocrinologist in the nation, to become an investigator proficient in interdisciplinary research using functional magnetic resonance imaging (fMRI) to study the causes of obesity. She has a career interest in the neuropsychology of obesity and diabetes and her focus is on the AI population in Minnesota. Obesity is a major health disparity in AIs, yet litle work is being done to unravel the neurobiology of this problem. The training and research activities will allow her to examine the complexities of computational neuroscience, functional neuroanatomy, and the contribution of opioidergic neurons to brain reward pathways. The application proposes an intensive, 5-year program of mentored research and formal training activities to enhance Dr. Beckman's skills and experience in: 1) clinical research methods and biostatistics, 2) technical aspects of fMRI data acquisition and analysis, and 3) role of opioidergic neurons in the neuroendocrine regulation of appetite. In the long term, Dr. Beckman will apply these translational research skills to study neuromodulation, cognitive restructuring, and opioid antagonists as potentially effective treatments for the public health problem of obesity in her AI patients who may be hyperresponsive to environmentally rewarding food cues. The research component of this career development award targets the neurobiology of behavioral responses to food in 60 AIs. The specific aims are to: 1) use fMRI to compare brain activation associated with the response to visual food cues in obese versus lean AI women, 2) use fMRI to compare the effects of naltrexone, an opioid antagonist, versus placebo, on brain activation associated with response to palatable food cues, 3) compare the effects of naltrexone versus placebo on food intake in obese and lean AI women, by measuring calories consumed. The University of Minnesota is an exceptional environment for Dr. Beckman to gain the skills needed to achieve her goals. The training component uses academic resources including the Division of Diabetes, Metabolism, and Endocrinology, Minnesota Obesity Center, Center for the Study of Impulsivity in Addiction, Center for Magnetic Resonance Imaging, and Clinical and Translational Science Institute. Dr. Beckman's mentors are highly regarded scientists in the areas of obesity, addiction, and neuroimaging.

描述（由申请人提供）：这个K23奖将允许Beckman博士，美国第一位美国印第安人（AI）成人内分泌学家，成为一名精通跨学科研究的研究人员，使用功能性磁共振成像（fMRI）研究肥胖的原因。她的职业兴趣是肥胖和糖尿病的神经心理学，她的重点是明尼苏达州的人工智能人群。肥胖是人工智能中一个主要的健康差异，但人们几乎没有做什么工作来解开这个问题的神经生物学。培训和研究活动将使她能够研究计算神经科学，功能神经解剖学的复杂性，以及阿片类神经元对大脑奖励途径的贡献。该申请提出了一项为期5年的强化指导研究和正式培训活动计划，以提高Beckman博士在以下方面的技能和经验：1）临床研究方法和生物统计学，2）fMRI数据采集和分析的技术方面，以及3）阿片类神经元在食欲神经内分泌调节中的作用。从长远来看，贝克曼博士将运用这些转化研究技能来研究神经调节、认知重建和阿片类拮抗剂，作为治疗AI患者肥胖公共卫生问题的潜在有效方法，这些患者可能对环境有益的食物线索反应过度。 该职业发展奖的研究部分针对60名人工智能对食物的行为反应的神经生物学。具体目标是：1）使用fMRI比较肥胖与瘦AI女性中与视觉食物线索反应相关的大脑激活，2）使用fMRI比较纳洛酮（一种阿片类拮抗剂）与安慰剂对与可口食物线索反应相关的大脑激活的影响，3）通过测量消耗的卡路里，比较纳洛酮与安慰剂对肥胖和瘦AI女性食物摄入的影响。 明尼苏达大学是贝克曼博士获得实现目标所需技能的特殊环境。培训部分使用学术资源，包括糖尿病，代谢和内分泌学，明尼苏达肥胖中心，成瘾冲动研究中心，磁共振成像中心，临床和转化科学研究所。贝克曼博士的导师是在肥胖、成瘾和神经成像领域备受推崇的科学家。