Endocrinology, Metabolism and Nutrition Training Grant

项目总结(见说明)： 本申请要求继续支持现有的内分泌学、新陈代谢和营养学培训补助金，支持3名医学博士和/或博士后研究员。这一应用包括将希望之城(COH)整合到港湾-加州大学洛杉矶分校/洛杉矶大学生物医学内分泌培训计划中，以及增加代谢组学和胎儿-产妇内分泌学培训部分，从而扩大了研究培训的机会。过去和现在的内分泌学和营养学核心计划提供了研究 培训134人；其中许多人继续或参加全职教学和/或研究活动，大多数人得到同行评议的支持。研究机会集中在5个主要领域：1)糖尿病、代谢和营养；2)代谢组学；3)生殖内分泌学和神经内分泌学；4)甲状腺、免疫反应和细胞信号；5)胎儿-母体内分泌学。这一多学科计划由NIH资助的三个中心[普通临床研究中心(GCRC)和Strong 临床营养研究部门；NICHD避孕临床试验中心和NCRR COH胰岛细胞资源中心]和世卫组织生殖中心。医生和基础科学家将根据过去的表现、推荐信和对未来学术生涯的承诺来选择。 博士生参加为期3年的全日制项目。医学博士实习生在培训助学金支持的两年内，或在三年的内科科学家学术计划中，全职从事研究或临床工作，这是他们研究努力的组成部分。所有研究员将参加加州大学洛杉矶分校-K30和正式计划的核心研究讲座，负责任的研究行为系列，研讨会，会议，以及与他们的导师和他们的合作研究小组的互动会议。这个项目的毕业生 将能够承担独立调查人员的角色，或过渡到有指导的教职员工支持的项目。研究设施主要设在洛杉矶生物医学中心一座25,000平方英尺的研究大楼内，设有内分泌学、围产学和胎儿-母体医学实验室；GCRC核心实验室、稳定同位素设施、生殖形态和分子生物学单位，以及计算机和生物统计设施。

PROJECT SUMMARY (See instructions): This application requests continued support for an existing training grant in Endocrinology, Metabolism and Nutrition supporting 3 MDs and/or PhD postdoctoral fellows. The application includes expanded opportunities for research training due to integration of the City of Hope (COH) into the Harbor-UCLA/LA BioMed Endocrine Training Program and the addition of metabolomics and fetal-maternal endocrinology training sections. The past and present Endocrinology and Nutrition Core Programs have provided research training to 134 individuals; many of whom continue or participated in full-time teaching and/or research activities, most with peer-reviewed support. Research opportunities are in 5 major areas: 1) Diabetes, Metabolism and Nutrition; 2) Metabolomics; 3) Reproductive Endocrinology and Neuroendocrinology; 4) Thyroid, Immune responses, and cell signaling; and 5) Fetal-Maternal Endocrinology. This multidisciplinary program is enhanced by three NIH funded Centers [General Clinical Research Center (GCRC) with strong Clinical Nutrition Research component; a NICHD Contraceptive Clinical Trials Center and a NCRR COH Islet Cell Resource Center] and a WHO Center in Reproduction. Physicians and basic scientists will be selected on the basis of past performance, letters of recommendation and commitment to a future academic career. The PhD trainees spend full-time in a 3 year program. MD trainees spend full-time in research or clinical effort in areas integral to their research endeavors during the 2 years supported by the training grant or in a 3 year physician scientist academic program. All fellows will participate in the UCLA-K30 and formal program of Core Research Lectures, Responsible Conduct of Research Series, seminars, conferences, and interactive sessions with their mentors and their collaborative research groups. Graduates of this program will be able to assume roles as independent investigators or transition into mentored faculty supported programs. The research facilities are primarily housed in a 25,000 sq ft research building at LA BioMed with laboratories in Endocrinology, Perinatology, and Fetal-Maternal Medicine; GCRC Core Laboratory, Stable Isotope Facility, Reproductive Morphology and Molecular Biology Units, and Computer and Biostatistics Facilities.