Cancer Center Support (CORE) Grant

描述（由申请人提供）：杰克逊实验室（TJL）癌症中心有58名成员组织成一个研究计划，建模癌症：干细胞治疗。研究重点是在小鼠生物学和基因组学的背景下了解癌症发生和发展的基本机制。小鼠是在参与癌症起始的个体基因水平和影响个体易感性的全基因组水平上检查癌症的最佳实验哺乳动物系统。在TJL癌症中心进行的研究利用了该中心支持的无与伦比的小鼠资源，从而增强了TJL癌症中心成员和更广泛的癌症研究社区使用的遗传和信息资源。由癌症中心支持的尖端仪器和技术先进的科学服务使所有成员能够进行可能需要专业知识和设备的实验，而这些实验在他们自己的实验室中是不存在的。 TJL的科学领导层直接监督癌症中心。Richard Woychik博士是TJL和癌症中心的主任。Barbara Knowles博士是TJL教育和合作副总裁，癌症中心副主任兼项目负责人。他们接受来自TJL和癌症中心科学监督委员会的外部建议。由癌症中心成员和高级管理人员组成的几个内部咨询委员会确保癌症中心在TJL的预算，招聘和整体运营中处于优先地位。 要求为科学资源和服务提供支持：a）小鼠模型资源，向癌症中心成员提供基因定义小鼠; B）计算科学，提供用于高级计算和统计分析的专业知识和分析工具; c）基因组科学，提供基因组扫描、等位基因分型和测序工具; d）组织学和显微镜科学，用于电子和光学显微镜、细胞遗传学、尸检和组织学; e）表型科学，用于基因表达、分子生物学、流式细胞术和蛋白质化学; f）用于细胞生物学和显微注射服务的生殖科学，以及g）用于小鼠再衍生、冷冻保存和重建的生殖科学。还要求为规划提供资金，重点是转化和跨学科研究。发展资金被要求用于一个试点项目计划，以刺激新的癌症研究机会，并为新的研究人员谁将带来额外的力量，TJL癌症中心的重点放在癌症的背景下，小鼠生物学和基因组学。

DESCRIPTION (provided by applicant): The Jackson Laboratory (TJL) Cancer Center has 58 members organized into one Research Program, Modeling Cancer: Stem Cells to Therapy. Research is focused on understanding the fundamental mechanisms of cancer initiation and progression in the context of mouse biology and genomics. The mouse is the best experimental mammalian system for examining cancer both at the level of individual genes that participate in cancer initiation and at the genome-wide scale that influences individual susceptibility. Research performed at TJL Cancer Center draws on the unparalleled mouse resources supported by the Center, and in turn enhances both the genetic and information resources maintained at TJL for use by TJL Cancer Center members and the wider cancer research community. The cutting edge instrumentation and technically sophisticated Scientific Services supported by the Cancer Center enable all members to conduct experiments that may require expertise and equipment that is not available in their own laboratories. The scientific leadership of TJL has direct oversight of the Cancer Center. Dr. Richard Woychik is Director of TJL and the Cancer Center. Dr. Barbara Knowles is Vice President for Education and Collaborations of TJL and Deputy Director and Program Leader of the Cancer Center. They receive external advice from the Board of Scientific Overseers for TJL and the Cancer Center. Several internal advisory committees composed of Cancer Center members and senior managers ensure that the Cancer Center is a priority in budgeting, recruiting, and overall operations at TJL. Support is requested for Scientific Resources and Services: a) the Mouse Models Resource,, which provides genetically defined mice to Cancer Center Members; b) Computational Sciences, for expertise and analytical tools for advanced computational and statistical analysis; c) Genome Sciences, for tools for genome scanning, allele typing, and sequencing; d) Histopathology and Microscopy Sciences, for electron and light microscopy, cytogenetics, necropsy and histology; e) Phenotyping Sciences for gene expression, molecular biology, flow cytometry, and protein chemistry; f) Reproductive Sciences for cell biology and microinjection services, and g) Reproductive Sciences for rederivation, cryopreservation and reconstitution of mice. Funds are also requested for planning, emphasizing translational and transdisciplinary research. Developmental funds are requested for a pilot project program to stimulate new cancer research opportunities and for new investigators who will bring additional strength to TJL Cancer Center's focus on cancer in the context of mouse biology and genomics.