Cancer Center Support (CORE) Grant

癌症中心支持 (CORE) 补助金

• 批准号: 9298392
• 负责人: Edison Tak-Bun Liu
• 金额: $ 210万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9298392
• 关键词: Address; Advanced Malignant Neoplasm; Biological Models; Cancer Center; Cancer Model; Cellular biology; Clinical assessments; Complex; Computational Science; Computer Analysis; Consultations; Core Grant; Cytogenetics; Development; Diagnosis; Disease; Drug Combinations; Drug Targeting; Evolution; Flow Cytometry; Funding; Gene Expression; Genetic; Genetic Engineering; Genetic Models; Genome; Genomic medicine; Genomics; Histology; Human; Laboratories; Leadership; Malignant Neoplasms; Mammalian Genetics; Microscopy; Modeling; Molecular; Mus; Patients; Phenotype; Pilot Projects; Proteomics; Public Health; Recruitment Activity; Research; Research Personnel; Resistance; Resource Sharing; Retreatment; Southwest Oncology Group; Statistical Data Interpretation; Stem cells; Structure; Technology; The Jackson Laboratory; United States; Xenograft procedure; anticancer research; cancer cell; cancer genomics; cancer research center director; human cancer mouse model; innovation; meetings; member; metabolomics; model development; mouse model; neoplasm resource; next generation sequencing; outreach; pre-clinical trial; precision oncology; prevent; programs; self-renewal; tumor progression

DESCRIPTION (provided by applicant): The Jackson Laboratory Cancer Center (JAXCC) provides a unique concentration of genetic and genomic expertise focusing on applications of murine model systems and systems genomics in addressing cancer questions. The JAXCC has 47 members in one Research Program, Genetic Models for Precision Cancer Medicine, comprising 3 related themes in cancer cell robustness, genetic and genomic complexity, and progenitor cell biology. Collectively, we seek to determine the molecular drivers of intrinsic cancer resistance, cancer evolution, adaptation, and self-renewal. Innovations In genomic technologies, computational analytics and mouse models for human cancers are integral to all themes, providing a robust interdisciplinary structure. The JAXCC now operates on 3 campuses: JAX Mammalian Genetics (Bar Harbor, ME) with a focus on mouse models for complex genetics; JAX Genomic Medicine (Farmington, CT), with a focus on human cancer genomics; and JAX-West (Sacramento, CA) with a focus on pre-clinical trials using patient-derived-xenograft (PDX) mouse models of human cancer. The scientific leadership of JAX has direct oversight of the Cancer Center: Dr. Edison Liu is President and CEO of JAX and Director of the JAXCC. Dr. Robert Braun Is Vice President for Research of JAX and Deputy Director of the Cancer Center. Drs. Carol Bult, Chengkai Dai and Frank McKeon are co-programming Leaders. Associate Directors for Regional Translational Partnerships (Dr. Kevin Mills) and Research Administration (Dr. Barbara Tennent) expand the leadership structure. A dedicated 7-member External Advisory Board (EAB) advises them. The new leadership, combined with recruitment of new senior and junior investigators, and a significant increase in institutional resources for cancer research heightens the impact ofthe JAXCC. This has been realized In the expanded JAXCC translational outreach through regional and national partnerships (e.g., SWOG). Support is requested for Shared Resources: a) Computational Sciences, for advanced computational and statistical analysis; b) Genome Technologies, for innovations in next generation sequencing, and in metabolomic and proteomic analyses; c) Cancer Model Development for consultation and project management in developing new models; d) Genetic Engineering Technologies for manipulating germline and somatic gene expression in mice; and e) Phenotyping Technologies for microscopy, cytogenetics, clinical assessment, histology and flow cytometry. Funds are also requested for support of annual EAB meetings and JAXCC member retreats. Developmental funds significantly supplemented by institutional funds are requested for a pilot project program to stimulate new cancer research opportunities and for support of new investigators to the JAXCC.

描述（由申请人提供）：杰克逊实验室癌症中心（JAXCC）提供独特的遗传和基因组专业知识，重点关注小鼠模型系统和系统基因组学在解决癌症问题中的应用。JAXCC在一个研究项目中有47名成员，即精准癌症医学的遗传模型，包括癌细胞鲁棒性，遗传和基因组复杂性以及祖细胞生物学的3个相关主题。总的来说，我们寻求确定内在癌症抗性，癌症演变，适应和自我更新的分子驱动因素。在基因组技术中，计算分析和人类癌症小鼠模型是所有主题的组成部分，提供了强大的跨学科结构。JAXCC现在在3个校区运营：JAX Mammalian Genetics（Bar Harbor，ME），专注于复杂遗传学的小鼠模型; JAX Genomic Medicine（法明顿，CT），专注于人类癌症基因组学;以及JAX-West（萨克拉门托，CA），专注于使用患者衍生异种移植（PDX）小鼠模型进行临床前试验。JAX的科学领导层直接监督癌症中心：Edison Liu博士是JAX的总裁兼首席执行官，也是JAXCC的主任。Robert Braun博士是JAX研究副总裁兼癌症中心副主任。Carol Bult博士、Chengkai Dai博士和Frank McKeon博士是Leaders的联合编程人员。区域翻译合作伙伴关系副主任（Kevin米尔斯博士）和研究管理副主任（Barbara Tennent博士）扩大了领导结构。一个专门的7人外部咨询委员会（EAB）为他们提供建议。新的领导层，加上新的高级和初级研究人员的招聘，以及癌症研究机构资源的显著增加，增强了JAXCC的影响力。通过区域和国家伙伴关系（例如，SWOG）。要求为共享资源提供支助：a）计算科学，用于先进的计算和统计分析; B）基因组技术，用于下一代测序以及代谢组学和蛋白质组学分析的创新; c）癌症模型开发，用于开发新模型的咨询和项目管理; d）基因工程技术，用于操纵小鼠生殖系和体细胞基因表达;和e）用于显微镜、细胞遗传学、临床评估、组织学和流式细胞术的表型技术。还要求提供资金，以支助欧洲咨询委员会年度会议和JAXCC成员务虚会。发展资金的机构资金大大补充了试点项目计划，以刺激新的癌症研究的机会，并为新的研究人员的JAXCC的支持。