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HUMAN TISSUE ACQUISITION AND PATHOLOGY

人体组织采集和病理学

基本信息

批准号：
8515960
负责人：
Gustavo Enrique Ayala
金额：
$ 19.61万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8515960
关键词：
Advocate Area Basic Science Benchmarking Biological Preservation Biopsy Breast Breast Lymphoma Budgets Cancer Center Colon Consent Cooperative Human Tissue Network Cost Analysis Data Databases Diagnostic Drug or chemical Tissue Distribution Electronics Emergency Situation Freezing Frozen Sections Future General Hospitals Genome Genomics Guidelines Hematoxylin and Eosin Staining Method Histologic Histological Techniques Histology Hospitals Human Resources Immunohistochemistry Individual Laboratories Language Maintenance Malignant neoplasm of ovary Medicine Methodology Office of Administrative Management Online Systems Operating Rooms Pancreas Paraffin Pathologist Pathology Patients Pediatric Hospitals Procedures Process Prostate Prostate Lymphoma Quality Control RNA Recontacts Rectum Relative (related person)Reproduction spores Research Research Personnel Resource Sharing Resources Services Specimen System Tablets Technology Texas Tissue Banking Tissue Banks Tissue Model Tissues Translating Translational Research Tumor Bank Vendor Veterans base college cost cost effective experience human disease human tissue instrumentation interest member operation programs two-dimensional

项目摘要

The Human Tissue Acquisition and Pathology Shared Resource (HTAP) is one of the largest Shared Resources for the DLDCC. The purpose is to offer sophisticated histologic techniques and to provide tissues to Cancer Center members. The Shared Resource director and key personnel have extensive experience in tissue acquisition, bank maintenance and distribution, and the various histologic services offered by the Resource, The HTAP has 2 major services: Tissue Acquisition and Distribution and Histology Services, The HTAP tumor banking and distribution services were built on the basis of previously existing tumor banks at BCM that began over 20 years ago. These include general tumor banks at the Ben Taub General Hospital Michael DeBakey VA hospital and Texas Children's Hospital; the Baylor Breast, Prostate and Lymphoma Spore banks, as well as banks in the fields of pancreas, colon and rectum, and ovarian cancers. They now have been rolled into the DLDCC HTAP and are integrated not only at the level of standard operating procedures (SOPs) and guidelines for distribution of tissues, but also in the administrative management of personnel and budgets. This synchronization of resources and efforts results in a synergistic operation that provides cost effective services, increased tumor banking accruals, better reliability and quality and a more fair distribution system. Tissue acquisition has almost tripled. Since 2006 we have also deployed a new proactive tissues acquisition system were "patient tissue advocate" is responsible not only for consenting, but for the acquisition and prompt transfer of tissues. Tissues are now banked frozen, paraffin, and for RNA preservation. Tissues are characterized and data entered into a newly established tissue bank database. We are implementing 2 dimensional barcoding and have established emergency backup systems for storage freezers. The histology services have all been centralized in a research exclusive histology laboratory under the HTAP. By centralizing our laboratory services and making this an exclusive research enterprise we have achieved stability of resources and services and cost efficiency relative to outside vendors or small individual research or departmental driven laboratories. Furthermore, by pooling instrumentation we provide better access to specialized technologies, methodologies and unique services that are specific to our cancer center. Histology has provided services to 33 investigators. We have also acquired and distributed tissues throughout programs in the DLDCC. In the future we plan to expand our banking efforts to diagnostic biopsies and expand our databasing efforts to include electronic tablet consenting.

人体组织采集和病理学共享资源（HTAP）是DLDCC最大的共享资源之一。其目的是提供先进的组织学技术，并提供组织癌症中心的成员。共享资源总监和主要人员在组织获取、库维护和分配以及资源提供的各种组织学服务方面具有丰富的经验。HTAP有2项主要服务：组织获取和分配以及组织学服务。HTAP肿瘤库和分配服务是在先前现有肿瘤库的基础上建立的，开始于20年前的战争。这些包括本陶布总医院迈克尔·德贝基VA医院和得克萨斯州儿童医院的一般肿瘤库;贝勒乳腺癌、前列腺癌和淋巴瘤孢子库，以及胰腺癌、结肠癌和直肠癌以及卵巢癌领域的库。它们现在已被纳入荒漠化、土地退化和气候变化协调委员会的HTAP，不仅在标准作业程序和组织分配准则一级，而且在人事和预算的行政管理方面都得到了整合。这种资源和努力的同步导致协同操作，提供具有成本效益的服务，增加肿瘤银行应计利润，更好的可靠性和质量以及更公平的分配系统。组织采集几乎增加了两倍。自2006年以来，我们还部署了一个新的主动组织获取系统，“患者组织倡导者”不仅负责同意，还负责组织的获取和及时转移。现在将组织冷冻、石蜡和RNA保存。对组织进行表征，并将数据输入新建立的组织库数据库。我们正在实施二维条形码，并为储存冷冻机建立了紧急备份系统。组织学服务都集中在HTAP下的研究专用组织学实验室。通过集中我们的实验室服务，使之成为一个独家的研究企业，我们已经实现了资源和服务的稳定性和成本效益相对于外部供应商或小型个人研究或部门驱动的实验室。此外，通过汇集仪器，我们可以更好地获得专门针对我们癌症中心的专业技术、方法和独特服务。组织学为33名调查员提供了服务。我们还在DLDCC的整个项目中获得并分发组织。在未来，我们计划将我们的银行业务扩展到诊断性活检，并将我们的数据库扩展到包括电子平板电脑同意。