HUMAN TISSUE ACQUISITION AND PATHOLOGY

人类组织获取与病理共享资源(HTAP)是DLDCC最大的共享资源之一。其目的是提供先进的组织学技术，并为癌症中心成员提供组织。共享资源总监和关键人员在组织获取、银行维护和分发以及资源提供的各种组织学服务方面拥有丰富的经验，HTAP有两项主要服务：组织获取和分发和组织学服务，HTAP肿瘤库和分发服务是在现有肿瘤库的基础上建立的，位于 开始于20多年前的BCM。其中包括本陶布综合医院Michael DeBakey VA医院和德克萨斯儿童医院的普通肿瘤库；贝勒乳房、前列腺癌和淋巴瘤孢子库，以及胰腺、结肠癌、直肠癌和卵巢癌领域的库。它们现在已被纳入DLDCC HTAP，不仅在组织分发的标准操作程序(SOP)和指南层面上，而且在人事和预算的行政管理方面也是如此。这种资源和努力的同步导致了协同运作，提供了具有成本效益的服务，增加了肿瘤库的应计收入，提高了可靠性和质量，并建立了更公平的分配系统。组织采集量几乎增加了两倍。自2006年以来，我们还部署了一种新的主动式组织获取系统，即“患者组织倡导者”不仅负责同意，而且负责组织的获取和迅速转移。组织现在被储存在冰冻、石蜡和RNA保存中。对组织进行了表征，并将数据输入新建立的组织银行数据库。我们正在实施二维条形码，并建立了仓储冷藏室的紧急备份系统。组织学服务全部集中在HTAP下的一个专门研究的组织学实验室。通过集中我们的实验室服务并使其成为一家独家研究企业，我们实现了相对于外部供应商或小型个别研究或部门驱动的实验室的资源和服务的稳定性和成本效益。此外，通过共享仪器，我们提供了更好的途径，获得专门针对我们癌症中心的专门技术、方法和独特的服务。组织学已经为33名调查人员提供了服务。我们还在DLDCC的整个项目中获取和分发组织。在未来，我们计划将我们的银行工作扩展到诊断活检，并将我们的数据库工作扩大到包括电子平板电脑同意。

The Human Tissue Acquisition and Pathology Shared Resource (HTAP) is one of the largest Shared Resources for the DLDCC. The purpose is to offer sophisticated histologic techniques and to provide tissues to Cancer Center members. The Shared Resource director and key personnel have extensive experience in tissue acquisition, bank maintenance and distribution, and the various histologic services offered by the Resource, The HTAP has 2 major services: Tissue Acquisition and Distribution and Histology Services, The HTAP tumor banking and distribution services were built on the basis of previously existing tumor banks at BCM that began over 20 years ago. These include general tumor banks at the Ben Taub General Hospital Michael DeBakey VA hospital and Texas Children's Hospital; the Baylor Breast, Prostate and Lymphoma Spore banks, as well as banks in the fields of pancreas, colon and rectum, and ovarian cancers. They now have been rolled into the DLDCC HTAP and are integrated not only at the level of standard operating procedures (SOPs) and guidelines for distribution of tissues, but also in the administrative management of personnel and budgets. This synchronization of resources and efforts results in a synergistic operation that provides cost effective services, increased tumor banking accruals, better reliability and quality and a more fair distribution system. Tissue acquisition has almost tripled. Since 2006 we have also deployed a new proactive tissues acquisition system were "patient tissue advocate" is responsible not only for consenting, but for the acquisition and prompt transfer of tissues. Tissues are now banked frozen, paraffin, and for RNA preservation. Tissues are characterized and data entered into a newly established tissue bank database. We are implementing 2 dimensional barcoding and have established emergency backup systems for storage freezers. The histology services have all been centralized in a research exclusive histology laboratory under the HTAP. By centralizing our laboratory services and making this an exclusive research enterprise we have achieved stability of resources and services and cost efficiency relative to outside vendors or small individual research or departmental driven laboratories. Furthermore, by pooling instrumentation we provide better access to specialized technologies, methodologies and unique services that are specific to our cancer center. Histology has provided services to 33 investigators. We have also acquired and distributed tissues throughout programs in the DLDCC. In the future we plan to expand our banking efforts to diagnostic biopsies and expand our databasing efforts to include electronic tablet consenting.