Osteoporotic Fractures in Men (MrOS) - Portland

男性骨质疏松性骨折 (MrOS) - 波特兰

基本信息

  • 批准号:
    8436051
  • 负责人:
  • 金额:
    $ 61.88万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2013
  • 资助国家:
    美国
  • 起止时间:
    2013-08-01 至 2018-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Age-related deterioration in bone, muscle and physical performance, manifested as osteoporosis, sarcopenia, and disability, are major causes of morbidity and mortality in the elderly. It is a priority to understand how musculoskeletal phenotypes and physical activity change with age, the factors that contribute to these changes, and how changes impact clinically important health outcomes. MrOS is a unique prospective study of 5994 older men that has been extremely productive in expanding our understanding of age-related change in musculoskeletal health. Initiated in 2000, it includes extensive longitudinal, objective, state-of-the-art assessments of bone, muscle, physical performance, physical activity and health outcomes, as well as biospecimen and imaging archives. We propose to extend these resources to allow a comprehensive and integrated understanding of the processes and consequences of musculoskeletal aging and decline in physical activity in older men studied over a 15 year period. The overall long term goal of the project is to identity men at risk of adverse health outcomes who may benefit from preventive measures and rehabilitation, discover new targets for treating and preventing declines in musculoskeletal health and activity, and improve our understanding of optimal aging (men who maintain their musculoskeletal health and activity levels over an average overall follow-up of 15 years). Specifically, we will leverage our repeated measurements to define age- related trajectories in phenotypes of musculoskeletal health, physical performance, and physical activity in order to determine factors that predict and contribute to these trajectories. We will test the hypotheses that favorable trajectories in musculoskeletal health are associated with lower risks of incident falls, fractures, disability and mortality and that age-related deterioration in bone, muscle and physical performance can occur concurrently; combined deterioration magnifies the risk of poor functional and health outcomes. Second, we will characterize change and trajectories in activity levels in older men using our repeated state-of-the-art questionnaire and objectively assessed energy expenditure from accelerometry. Third, we will take advantage of a linkage of MrOS with Medicare Claims data to determine the association of trajectories in musculoskeletal phenotypes and activity with inpatient and nursing home related health care utilization. Fourth, we will examine novel characteristics of cortical bone that may cause age-related skeletal fragility by using high resolution peripheral quantitative computed tomography to measure cortical porosity. We will relate trajectories of musculoskeletal health and activity to these measures of cortical bone and test whether increased cortical porosity is related to fractures. Finally, we will continue to leverage MrOS as a platform for new science and the training of investigators. Our application is consistent with the mission of the NIA and NIAMS to conduct research related to the aging process and diseases and conditions associated with musculoskeletal aging, and foster the development of new research scientists in this scientific area.
描述(由申请人提供):骨质疏松症相关的骨、肌肉和体能退化,表现为骨质疏松症、肌肉减少症和残疾,是老年人发病和死亡的主要原因。首先要了解肌肉骨骼表型和体力活动如何随年龄变化,导致这些变化的因素,以及这些变化如何影响临床重要的健康结果。MrOS是一项对5994名老年男性进行的独特前瞻性研究,在扩大我们对肌肉骨骼健康年龄相关变化的理解方面非常富有成效。它于2000年启动,包括对骨骼、肌肉、体能、体育活动和健康结果以及生物标本和成像档案进行广泛的纵向、客观和最先进的评估。我们建议扩展这些资源,以便全面和综合了解肌肉骨骼老化的过程和后果,并在15年的时间内研究老年男性体力活动下降。该项目的总体长期目标是识别可能受益于预防措施和康复的不良健康结果风险的男性,发现治疗和预防肌肉骨骼健康和活动下降的新目标,并提高我们对最佳老龄化的理解(平均整体随访15年以上保持肌肉骨骼健康和活动水平的男性)。具体而言,我们将利用我们的重复测量来定义肌肉骨骼健康、身体表现和身体活动表型中与年龄相关的轨迹,以确定预测和促成这些轨迹的因素。我们将检验以下假设:肌肉骨骼健康的良好轨迹与较低的意外福尔斯、骨折、残疾和死亡风险相关,并且与年龄相关的骨骼、肌肉和身体表现恶化可能同时发生;综合恶化放大了功能和健康结果不良的风险。其次,我们将使用我们重复的最先进的问卷和客观评估的能量消耗加速度计的变化和轨迹的活动水平在老年男性。第三,我们将利用MrOS与医疗保险索赔数据的联系,以确定肌肉骨骼表型和活动轨迹与住院和疗养院相关的医疗保健利用的关联。第四,我们将通过使用高分辨率外周定量计算机断层扫描来测量皮质孔隙度,检查皮质骨的新特征,这些特征可能导致与年龄相关的骨骼脆弱性。我们将把肌肉骨骼健康和活动的轨迹与皮质骨的这些测量结果联系起来,并测试皮质骨孔隙率的增加是否与骨折有关。最后,我们将继续利用MrOS作为新科学和研究人员培训的平台。我们的申请与NIA和NIAMS的使命一致,即进行与衰老过程和与肌肉骨骼衰老相关的疾病和病症相关的研究,并促进这一科学领域新研究科学家的发展。

项目成果

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ERIC S. ORWOLL其他文献

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{{ truncateString('ERIC S. ORWOLL', 18)}}的其他基金

Osteoporotic Fractures in Men (MrOS) - Portland
男性骨质疏松性骨折 (MrOS) - 波特兰
  • 批准号:
    9921179
  • 财政年份:
    2013
  • 资助金额:
    $ 61.88万
  • 项目类别:
Osteoporotic Fractures in Men (MrOS) - Portland
男性骨质疏松性骨折 (MrOS) - 波特兰
  • 批准号:
    9041473
  • 财政年份:
    2013
  • 资助金额:
    $ 61.88万
  • 项目类别:
Osteoporotic Fractures in Men (MrOS) - Portland
男性骨质疏松性骨折 (MrOS) - 波特兰
  • 批准号:
    8897222
  • 财政年份:
    2013
  • 资助金额:
    $ 61.88万
  • 项目类别:
OREGON CLINICAL AND TRANSLATIONAL RESEARCH INSTITUTE
俄勒冈临床与转化研究所
  • 批准号:
    8365044
  • 财政年份:
    2011
  • 资助金额:
    $ 61.88万
  • 项目类别:
CTSA INFRASTRUCTURE FOR CLINICAL TRIALS
CTSA 临床试验基础设施
  • 批准号:
    8365045
  • 财政年份:
    2011
  • 资助金额:
    $ 61.88万
  • 项目类别:
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCH
CTSA 儿科研究基础设施
  • 批准号:
    8365046
  • 财政年份:
    2011
  • 资助金额:
    $ 61.88万
  • 项目类别:
CTSA INFRASTRUCTURE FOR AIDS RESEARCH
CTSA 艾滋病研究基础设施
  • 批准号:
    8365047
  • 财政年份:
    2011
  • 资助金额:
    $ 61.88万
  • 项目类别:
CTSA INFRASTRUCTURE FOR AIDS RESEARCH
CTSA 艾滋病研究基础设施
  • 批准号:
    8365048
  • 财政年份:
    2011
  • 资助金额:
    $ 61.88万
  • 项目类别:
CTSA INFRASTRUCTURE FOR AIDS RESEARCH
CTSA 艾滋病研究基础设施
  • 批准号:
    8173780
  • 财政年份:
    2010
  • 资助金额:
    $ 61.88万
  • 项目类别:
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCH
CTSA 儿科研究基础设施
  • 批准号:
    8173781
  • 财政年份:
    2010
  • 资助金额:
    $ 61.88万
  • 项目类别:

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急性髓性白血病的年龄因素、突变和化学抑制剂
  • 批准号:
    8306217
  • 财政年份:
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  • 批准号:
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  • 财政年份:
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  • 资助金额:
    $ 61.88万
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Age factors, mutations, and chemical suppressors of acute myelogenous leukemia
急性髓性白血病的年龄因素、突变和化学抑制剂
  • 批准号:
    7904815
  • 财政年份:
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  • 资助金额:
    $ 61.88万
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急性髓性白血病的年龄因素、突变和化学抑制剂
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    7659629
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