Osteoporotic Fractures in Men (MrOS) - Portland

骨骼、肌肉和体能的骨骼相关退化，表现为骨质疏松症、肌肉减少症， 和残疾是老年人发病和死亡的主要原因。首先要了解 肌肉骨骼表型和体力活动随着年龄的变化，这些因素有助于这些 变化，以及变化如何影响临床重要的健康结果。MrOS是一项独特的前瞻性研究 5994名老年男性的研究，在扩大我们对与年龄有关的变化的理解方面非常富有成效。 肌肉骨骼健康。它于2000年启动，包括广泛的纵向，客观，最先进的 评估骨骼、肌肉、体能、体力活动和健康结果，以及 生物标本和影像档案。我们建议扩大这些资源，以便进行全面和 综合了解肌肉骨骼老化和身体机能下降的过程和后果， 在15年的时间里研究了老年男性的活动。该项目的总体长期目标是确定男子的身份， 有可能从预防措施和康复中受益的不良健康结果的风险， 治疗和预防肌肉骨骼健康和活动下降的目标，并改善我们的 了解最佳老化（男性谁保持他们的肌肉骨骼健康和活动水平超过一个 平均随访15年）。具体来说，我们将利用重复测量来定义年龄- 肌肉骨骼健康、身体表现和身体活动表型的相关轨迹， 以确定预测和促成这些轨迹的因素。我们将测试假设， 肌肉骨骼健康的良好轨迹与较低的意外福尔斯，骨折， 残疾和死亡率，以及与年龄有关的骨骼、肌肉和身体机能的退化， 同时;综合恶化放大了功能和健康结果不良的风险。二是 将使用我们重复的最先进的技术来描述老年男性活动水平的变化和轨迹 问卷调查，并从加速度计客观评估能量消耗。第三，我们将利用 MrOS与医疗保险索赔数据的联系，以确定肌肉骨骼运动轨迹的关联 表型和活动与住院和疗养院相关的卫生保健利用。第四，我们将研究 通过使用高分辨率，可能导致与年龄相关的骨骼脆性的皮质骨的新特征 外周定量计算机断层扫描以测量皮质孔隙度。我们将把 肌肉骨骼健康和活动，以这些措施的皮质骨和测试是否增加皮质骨 孔隙度与裂缝有关。最后，我们将继续利用MrOS作为新科学的平台， 调查人员的培训。我们的申请与NIA和NIAMS的使命一致， 与衰老过程以及与肌肉骨骼衰老相关的疾病和状况有关的研究，以及 促进这一科学领域新的研究科学家的发展。

Age-related deterioration in bone, muscle and physical performance, manifested as osteoporosis, sarcopenia, and disability, are major causes of morbidity and mortality in the elderly. It is a priority to understand how musculoskeletal phenotypes and physical activity change with age, the factors that contribute to these changes, and how changes impact clinically important health outcomes. MrOS is a unique prospective study of 5994 older men that has been extremely productive in expanding our understanding of age-related change in musculoskeletal health. Initiated in 2000, it includes extensive longitudinal, objective, state-of-the-art assessments of bone, muscle, physical performance, physical activity and health outcomes, as well as biospecimen and imaging archives. We propose to extend these resources to allow a comprehensive and integrated understanding of the processes and consequences of musculoskeletal aging and decline in physical activity in older men studied over a 15 year period. The overall long term goal of the project is to identity men at risk of adverse health outcomes who may benefit from preventive measures and rehabilitation, discover new targets for treating and preventing declines in musculoskeletal health and activity, and improve our understanding of optimal aging (men who maintain their musculoskeletal health and activity levels over an average overall follow-up of 15 years). Specifically, we will leverage our repeated measurements to define age- related trajectories in phenotypes of musculoskeletal health, physical performance, and physical activity in order to determine factors that predict and contribute to these trajectories. We will test the hypotheses that favorable trajectories in musculoskeletal health are associated with lower risks of incident falls, fractures, disability and mortality and that age-related deterioration in bone, muscle and physical performance can occur concurrently; combined deterioration magnifies the risk of poor functional and health outcomes. Second, we will characterize change and trajectories in activity levels in older men using our repeated state-of-the-art questionnaire and objectively assessed energy expenditure from accelerometry. Third, we will take advantage of a linkage of MrOS with Medicare Claims data to determine the association of trajectories in musculoskeletal phenotypes and activity with inpatient and nursing home related health care utilization. Fourth, we will examine novel characteristics of cortical bone that may cause age-related skeletal fragility by using high resolution peripheral quantitative computed tomography to measure cortical porosity. We will relate trajectories of musculoskeletal health and activity to these measures of cortical bone and test whether increased cortical porosity is related to fractures. Finally, we will continue to leverage MrOS as a platform for new science and the training of investigators. Our application is consistent with the mission of the NIA and NIAMS to conduct research related to the aging process and diseases and conditions associated with musculoskeletal aging, and foster the development of new research scientists in this scientific area.