Osteoporotic Fractures in Men (MrOS) - Portland

男性骨质疏松性骨折 (MrOS) - 波特兰

• 批准号: 9041473
• 负责人: ERIC S. ORWOLL
• 金额: $ 42.57万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9041473
• 关键词: Accelerometer; Age; Age Factors; Aging; Aging-Related Process; Area; Biological Factors; Bone Density; Cessation of life; Characteristics; Data; Databases; Deterioration; Development; Disease; Elderly; Energy Metabolism; Finite Element Analysis; Fostering; Fracture; Gait speed; Goals; Gonadal Steroid Hormones; Hand Strength; Health; Healthcare; Hospitalization; Impaired cognition; Inflammation; Inpatients; Lead; Leg; Life; Long-Term Care; Maintenance; Measurement; Measures; Medicare claim; Mission; Morbidity - disease rate; Muscle; Musculoskeletal; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Nursing Homes; Older Population; Osteoporosis; Outcome; Participant; Peripheral; Phase; Phenotype; Physical Performance; Physical activity; Porosity; Preventive measure; Process; Property; Prospective Studies; Questionnaires; Radial; Rehabilitation therapy; Renal function; Research; Resolution; Resources; Risk; Science; Scientific Inquiry; Scientist; Skilled Nursing Facilities; Structure; Testing; Visit; Vitamin D; Woman; X-Ray Computed Tomography; adverse outcome; age related; bone; bone strength; career; cohort; design; disability; falls; follow-up; health care service utilization; image archival system; improved; investigator training; men; mortality; novel; older men; osteoporosis with pathological fracture; physical conditioning; prevent; repository; sarcopenia; sedentary lifestyle; skeletal; tibia; web site

DESCRIPTION (provided by applicant): Age-related deterioration in bone, muscle and physical performance, manifested as osteoporosis, sarcopenia, and disability, are major causes of morbidity and mortality in the elderly. It is a priority to understand how musculoskeletal phenotypes and physical activity change with age, the factors that contribute to these changes, and how changes impact clinically important health outcomes. MrOS is a unique prospective study of 5994 older men that has been extremely productive in expanding our understanding of age-related change in musculoskeletal health. Initiated in 2000, it includes extensive longitudinal, objective, state-of-the-art assessments of bone, muscle, physical performance, physical activity and health outcomes, as well as biospecimen and imaging archives. We propose to extend these resources to allow a comprehensive and integrated understanding of the processes and consequences of musculoskeletal aging and decline in physical activity in older men studied over a 15 year period. The overall long term goal of the project is to identity men at risk of adverse health outcomes who may benefit from preventive measures and rehabilitation, discover new targets for treating and preventing declines in musculoskeletal health and activity, and improve our understanding of optimal aging (men who maintain their musculoskeletal health and activity levels over an average overall follow-up of 15 years). Specifically, we will leverage our repeated measurements to define age- related trajectories in phenotypes of musculoskeletal health, physical performance, and physical activity in order to determine factors that predict and contribute to these trajectories. We will test the hypotheses that favorable trajectories in musculoskeletal health are associated with lower risks of incident falls, fractures, disability and mortality and that age-related deterioration in bone, muscle and physical performance can occur concurrently; combined deterioration magnifies the risk of poor functional and health outcomes. Second, we will characterize change and trajectories in activity levels in older men using our repeated state-of-the-art questionnaire and objectively assessed energy expenditure from accelerometry. Third, we will take advantage of a linkage of MrOS with Medicare Claims data to determine the association of trajectories in musculoskeletal phenotypes and activity with inpatient and nursing home related health care utilization. Fourth, we will examine novel characteristics of cortical bone that may cause age-related skeletal fragility by using high resolution peripheral quantitative computed tomography to measure cortical porosity. We will relate trajectories of musculoskeletal health and activity to these measures of cortical bone and test whether increased cortical porosity is related to fractures. Finally, we will continue to leverage MrOS as a platform for new science and the training of investigators. Our application is consistent with the mission of the NIA and NIAMS to conduct research related to the aging process and diseases and conditions associated with musculoskeletal aging, and foster the development of new research scientists in this scientific area.

描述（由申请人提供）：与年龄相关的骨骼、肌肉和身体机能退化，表现为骨质疏松症、肌肉减少症和残疾，是老年人发病和死亡的主要原因。首要任务是了解肌肉骨骼表型和体力活动如何随年龄变化、导致这些变化的因素以及这些变化如何影响临床上重要的健康结果。 MrOS 是一项针对 5994 名老年男性的独特前瞻性研究，在扩大我们对肌肉骨骼健康与年龄相关变化的理解方面非常富有成效。它于 2000 年启动，包括对骨骼、肌肉、身体表现、身体活动和健康结果以及生物样本和成像档案进行广泛的纵向、客观、最先进的评估。我们建议扩展这些资源，以便全面、综合地了解 15 年来研究的老年男性肌肉骨骼衰老和体力活动下降的过程和后果。该项目的总体长期目标是识别面临不良健康结果风险的男性，他们可以从预防措施和康复中受益，发现治疗和预防肌肉骨骼健康和活动下降的新目标，并提高我们对最佳衰老的理解（在平均 15 年的整体随访中保持肌肉骨骼健康和活动水平的男性）。具体来说，我们将利用重复测量来定义肌肉骨骼健康表型、身体表现和身体活动中与年龄相关的轨迹，以确定预测和影响这些轨迹的因素。我们将检验以下假设：肌肉骨骼健康的有利轨迹与较低的跌倒、骨折、残疾和死亡风险相关，并且骨骼、肌肉和身体机能与年龄相关的退化可能同时发生；综合恶化会放大功能和健康结果不佳的风险。其次，我们将使用我们重复的最先进的调查问卷和通过加速度测量客观评估的能量消耗来描述老年男性活动水平的变化和轨迹。第三，我们将利用 MrOS 与医疗保险索赔数据的联系来确定肌肉骨骼表型和活动的轨迹与住院和疗养院相关医疗保健利用的关联。第四，我们将通过使用高分辨率外周定量计算机断层扫描来测量皮质孔隙度，研究可能导致与年龄相关的骨骼脆弱性的皮质骨的新特征。我们将把肌肉骨骼健康和活动的轨迹与皮质骨的这些测量联系起来，并测试皮质孔隙度的增加是否与骨折有关。最后，我们将继续利用 MrOS 作为新科学和研究人员培训的平台。我们的应用与 NIA 和 NIAMS 的使命是一致的，即开展与衰老过程以及与肌肉骨骼衰老相关的疾病和状况相关的研究，并促进该科学领域新研究科学家的发展。