Aging the Central Nervous System and Mobility in Older Adults

数据摘要/摘要 这是一个为期三年的U13合作会议补助金的申请，由Rosano，Studenski博士组织， Chen与美国老年学会合作，强调了专注于老年人的新兴领域。 社区老年人中枢神经系统（CNS）与活动障碍之间的相互作用 成年人了该系列会议旨在促进研究成果和新思想的交流，以及 解决相关的方法问题和研究障碍，以确定CNS在移动性方面的作用 损失我们的长期目标是促进将研究成果转化为干预措施， 老年人的流动性。 老年人的步态和平衡问题是常见的，严重致残，并施加紧迫的临床 在老年社区工作的人面临的挑战。到目前为止，已经在一个 许多明确定义和确定的运动相关疾病和障碍，如帕金森氏症 疾病和中风。然而，生活在一般社区环境中的老年人的行动障碍是 在很大程度上研究不足，特别是关于中枢神经系统的作用。研究中的这些差距阻碍了 发展明确定义的病理生理学、临床术语和有效的治疗策略。 面临身体残疾风险的老年人人数正在迅速增加， 与丧失独立性、生活质量大幅下降、住院治疗和早产相关 死亡因此，了解这一人群的活动障碍机制有可能 大大改善老年人的临床和预防护理。 最近，新出现的证据已经开始支持CNS和脑可塑性在调节神经元功能中的重要性。 老年人的流动性，并可能为管理和治疗流动性提供新的见解和策略 问题我们提出了一系列的三个相互关联的研讨会，建立在这些令人兴奋的发现和促进 系统、有效地研究老年人中枢神经系统与活动能力的关系。 这些讲习班将汇集来自基础科学和动物模型相关学科的专家， 流行病学和临床研究，以1）检查基础科学，流行病学和 临床观点，并加强从动物研究到人类正常衰老和 在个人和人口层面的疾病; 2）促进基础，流行病学和 相关学科的临床科学家，否则他们可能没有机会一起工作;以及 3)确定知识差距、进展障碍、替代战略和未来调查的前景， 讨论新的研究成果。 这三个讲习班都有一个独特但相互关联的科学重点：1）讲习班1将建立 迄今为止CNS与活动性之间关系的最佳证据，并将确定最新技术水平 量化CNS和流动性措施的技术; 2）研讨会2将建立在研讨会1的基础上， 年龄相关的CNS损伤可能导致运动障碍的机制和原因;以及3） 讲习班3将在讲习班1和2的基础上确定最有希望的预防和干预措施 目前正在研究和/或应在今后的研究中加以解决的战略。 为了最大限度地实现这一系列会议的长期目标， 每一个工作坊的设计，使一个建立到下一个。此外，所有三个讲习班都将讨论 与行动障碍研究有关的方法学领域， 有效分析和沟通评估之间的多维和多成分相关性 措施在每次研讨会结束时，与会者将负责提出以下建议： 关于连接CNS和移动性的病理生理学知识，新的评估技术， 统计方法、最有希望的干预战略和/或公共信息共享建议。到 为了方便讨论，研讨会将以40名与会者为限，并仅限应邀参加。 不过，讲习班的成果将按照传播计划予以广泛传播。 本系列会议的目的是：1）检查现有的基础，流行病学， 临床观点，并加强从动物研究到人类正常衰老和 在个人和人口层面的疾病; 2）促进基础，流行病学和 相关学科的临床科学家，否则他们可能没有机会一起工作; 3） 确定知识差距、进展障碍、替代战略和未来调查的前景， 讨论新兴的研究成果; 4）强调CNS和移动性的尖端方法 措施; 5）支持初级调查员，妇女，少数民族和其他代表性不足的参与 6）通过提供充足的信息，鼓励研讨会参与者进行讨论和交流意见 互动时间和使用多媒体演示格式，包括视频;以及7）传播调查结果， 讨论，并通过GSA的研讨会向研究人员、临床医生和公众提出建议 年度科学会议，以及向各种相关期刊提交协调的个人论文（例如， 神经病学，步态和步态，行为和大脑功能，运动障碍，老年学杂志： 医学科学、衰老神经科学前沿等）用于出版。

PROGRAM SUMMARY/ABSTRACT This application for a three-year U13 cooperative conference grant, organized by Drs. Rosano, Studenski, and Chen in partnership with the Gerontological Society of America, highlights the emerging field focusing on the interplay between the central nervous system (CNS) and mobility impairment in community-dwelling older adults. This conference series intends to foster the exchange of research findings and new ideas, as well as address related methodological issues and research barriers, in order to identify the role of the CNS in mobility loss. Our long-term goal is to facilitate the translation of research results into interventions that improve mobility for older adults. Gait and balance problems in older adults are common and severely disabling, and impose pressing clinical challenges among those in and working with the geriatric community. To date, advances have been made in a number of well-defined and established movement-related diseases and disorders, such as Parkinson's disease and stroke. However, mobility impairments in older adults living in general community settings are largely understudied, particularly regarding the role of the CNS. These gaps in research have hampered the development of clearly defined pathophysiology, clinical terminology, and effective treatment strategy. The number of older adults at risk for physical disability is rapidly increasing, and mobility impairment is associated with loss of independence, substantially reduced quality of life, hospitalization, and premature death. Thus, understanding the mechanisms of mobility impairment in this population has the potential to greatly improve clinical and preventive care for older adults. Recently, emerging evidence has begun to support the importance of CNS and brain plasticity in regulating mobility in older adults and may provide new insights and strategies for managing and treating mobility problems. We propose a series of three interrelated workshop that build on these exciting findings and promote systematic and effective studies on the relationship between the CNS and mobility in aging. These workshops will bring together experts from interrelated disciplines in basic science and animal models, epidemiology, and clinical research to 1) examine existing evidence from basic science, epidemiological, and clinical perspectives and enhance links from animal studies to human investigation of both normal aging and disease at the individual and population level; 2) promote collaboration between basic, epidemiological, and clinical scientists of interrelated disciplines who might not otherwise have an opportunity to work together; and 3) identify knowledge gaps, barriers to progress, alternative strategies, and prospects for future inquiry through discussions of emerging research findings. Each of these three workshops has a distinct but interrelated scientific focus: 1) Workshop 1 will establish the best evidence to date for a relationship between the CNS and mobility and will identify state-of-the-art technology to quantify CNS and mobility measures; 2) Workshop 2 will build on Workshop 1 and ascertain the mechanisms and causes by which age-related CNS impairment may cause mobility impairment; and 3) Workshop 3 will build on Workshops 1 and 2 to identify the most promising prevention and intervention strategies that are currently being studied and/or should be addressed in future studies. To maximize the possibility of achieving the long-term goal of this conference series, the scientific focus of each workshop is designed so that one builds into the next. In addition, all three workshops will address methodological areas related to the study of mobility impairment, including analytical approaches to implement effective analysis and communication of multidimensional and multicomponent correlations between assessed measures. At the end of each workshop, the attendees will be charged with recommending the following: state of knowledge on the pathophysiology linking the CNS and mobility, new assessment technologies and statistical approaches, most promising intervention strategies, and/or public information sharing proposals. To facilitate discussion, workshop attendance will be limited to 40 participants and will be by invitation only. However, the outcomes of the workshops will be broadly disseminated as outlined in the dissemination plan. The aims of this conference series are to 1) examine existing evidence from basic, epidemiological, and clinical perspectives and enhance links from animal studies to human investigation of both normal aging and disease at the individual and population level; 2) promote collaborations between basic, epidemiological, and clinical scientists of interrelated disciplines who might not otherwise have an opportunity to work together; 3) identify knowledge gaps, barriers to progress, alternative strategies, and prospects for future inquiry through discussions of emerging research findings; 4) emphasize cutting-edge methodologies for CNS and mobility measures; 5) support involvement from junior investigators, women, minorities, and other underrepresented groups; 6) encourage discussions and exchanges of ideas from workshop participants by providing ample time for interactions and using multimedia presentation formats, including videos; and 7) disseminate findings, discussions, and recommendations to investigators, clinicians, and the public through symposia at the GSA Annual Scientific Meeting, as well as submit coordinated individual papers to a variety of related journals (e.g., Neurology, Gait & Posture, Behavioral and Brain Functions, Movement Disorders, Journal of Gerontology: Medical Sciences, Frontiers in Aging Neuroscience, etc.) for publication.