Aging the Central Nervous System and Mobility in Older Adults

节目摘要/摘要 申请为期三年的U13合作会议补助金，由Rosano博士、Studenski博士和 陈与美国老年学会合作，重点介绍了专注于 社区老年人中枢神经系统(CNS)与行动能力障碍的相互作用 成年人。这一系列会议旨在促进研究成果和新思想的交流，以及 处理相关的方法问题和研究障碍，以确定中枢神经系统在机动性方面的作用 损失。我们的长期目标是促进将研究成果转化为改善 老年人的机动性。 老年人的步态和平衡问题很常见，严重致残，临床上非常紧迫。 那些在老年社区工作的人面临的挑战。到目前为止，已经在一个 明确定义和确定的与运动有关的疾病和障碍的数量，如帕金森氏症 疾病和中风。然而，生活在一般社区环境中的老年人的行动能力障碍是 在很大程度上没有得到充分的研究，特别是关于中枢神经系统的作用。这些研究上的差距阻碍了 制定明确的病理生理学、临床术语和有效的治疗策略。 面临身体残疾风险的老年人数量正在迅速增加，行动不便的人 与丧失独立性、显著降低生活质量、住院和早产有关 死亡。因此，了解这一人群中行动能力障碍的机制有可能 极大地改善老年人的临床和预防护理。 最近，新的证据已经开始支持中枢神经系统和大脑可塑性在调节中的重要性。 老年人的行动能力，并可能为管理和治疗行动能力提供新的见解和策略 有问题。我们提出了一系列三个相互关联的研讨会，以这些令人兴奋的发现为基础，并促进 系统有效地研究了中枢神经系统与衰老时的活动能力之间的关系。 这些研讨会将汇集基础科学和动物模型领域相关学科的专家， 流行病学和临床研究，以1)检查现有的基础科学、流行病学和 临床观点和加强从动物研究到人类研究的正常衰老和 个人和人口层面的疾病；2)促进基础、流行病学和 相关学科的临床科学家，否则他们可能没有机会合作；以及 3)通过以下途径确定知识差距、进展障碍、替代战略和未来调查前景 对新出现的研究成果的讨论。 这三个讲习班都有一个不同但相互关联的科学重点：1)讲习班1将建立 迄今为止证明中枢神经系统和移动性之间关系的最好证据，并将确定最先进的 量化CNS和移动性衡量标准的技术；2)研讨会2将以研讨会1为基础，并确定 与年龄相关的中枢神经系统损伤可能导致行动能力障碍的机制和原因； 研讨会3将在研讨会1和2的基础上，确定最有希望的预防和干预措施 目前正在研究和/或应在今后的研究中讨论的战略。 为了最大限度地实现这次会议系列的长期目标，科学的重点是 每个车间的设计都是为了让一个车间与下一个车间相结合。此外，所有三个研讨会都将讨论 与行动障碍研究有关的方法学领域，包括执行 有效分析和沟通被评估对象之间的多维和多成分相关性 措施。在每个研讨会结束时，与会者将负责推荐以下内容： 关于中枢神经系统和移动性之间的病理生理学的知识，新的评估技术和 统计方法、最有希望的干预战略和/或公共信息共享提议。至 为方便讨论，工作坊的出席人数限制为40人，且仅限受邀参加。 不过，如传播计划所述，讲习班的成果将得到广泛传播。 本系列会议的目的是：1)从基础、流行病学和 临床观点和加强从动物研究到人类研究的正常衰老和 个人和人口层面的疾病；2)促进基础、流行病学和 相关学科的临床科学家，否则可能没有机会合作；3) 通过以下途径确定知识差距、取得进展的障碍、替代战略和未来调查前景 讨论新的研究成果；4)强调针对CNS和移动性的尖端方法 措施；5)支持初级调查人员、妇女、少数群体和其他任职人数不足的人的参与 小组；6)鼓励研讨会参与者讨论和交流想法，提供充足的 互动和使用包括视频在内的多媒体演示格式的时间；以及7)传播调查结果， 通过GSA的研讨会，向研究人员、临床医生和公众提供讨论和建议 年度科学会议，以及向各种相关期刊提交协调的个人论文(例如， 神经学，步态和姿势，行为和脑功能，运动障碍，老年学杂志： 医学、老龄神经科学前沿等)以供出版。

PROGRAM SUMMARY/ABSTRACT This application for a three-year U13 cooperative conference grant, organized by Drs. Rosano, Studenski, and Chen in partnership with the Gerontological Society of America, highlights the emerging field focusing on the interplay between the central nervous system (CNS) and mobility impairment in community-dwelling older adults. This conference series intends to foster the exchange of research findings and new ideas, as well as address related methodological issues and research barriers, in order to identify the role of the CNS in mobility loss. Our long-term goal is to facilitate the translation of research results into interventions that improve mobility for older adults. Gait and balance problems in older adults are common and severely disabling, and impose pressing clinical challenges among those in and working with the geriatric community. To date, advances have been made in a number of well-defined and established movement-related diseases and disorders, such as Parkinson's disease and stroke. However, mobility impairments in older adults living in general community settings are largely understudied, particularly regarding the role of the CNS. These gaps in research have hampered the development of clearly defined pathophysiology, clinical terminology, and effective treatment strategy. The number of older adults at risk for physical disability is rapidly increasing, and mobility impairment is associated with loss of independence, substantially reduced quality of life, hospitalization, and premature death. Thus, understanding the mechanisms of mobility impairment in this population has the potential to greatly improve clinical and preventive care for older adults. Recently, emerging evidence has begun to support the importance of CNS and brain plasticity in regulating mobility in older adults and may provide new insights and strategies for managing and treating mobility problems. We propose a series of three interrelated workshop that build on these exciting findings and promote systematic and effective studies on the relationship between the CNS and mobility in aging. These workshops will bring together experts from interrelated disciplines in basic science and animal models, epidemiology, and clinical research to 1) examine existing evidence from basic science, epidemiological, and clinical perspectives and enhance links from animal studies to human investigation of both normal aging and disease at the individual and population level; 2) promote collaboration between basic, epidemiological, and clinical scientists of interrelated disciplines who might not otherwise have an opportunity to work together; and 3) identify knowledge gaps, barriers to progress, alternative strategies, and prospects for future inquiry through discussions of emerging research findings. Each of these three workshops has a distinct but interrelated scientific focus: 1) Workshop 1 will establish the best evidence to date for a relationship between the CNS and mobility and will identify state-of-the-art technology to quantify CNS and mobility measures; 2) Workshop 2 will build on Workshop 1 and ascertain the mechanisms and causes by which age-related CNS impairment may cause mobility impairment; and 3) Workshop 3 will build on Workshops 1 and 2 to identify the most promising prevention and intervention strategies that are currently being studied and/or should be addressed in future studies. To maximize the possibility of achieving the long-term goal of this conference series, the scientific focus of each workshop is designed so that one builds into the next. In addition, all three workshops will address methodological areas related to the study of mobility impairment, including analytical approaches to implement effective analysis and communication of multidimensional and multicomponent correlations between assessed measures. At the end of each workshop, the attendees will be charged with recommending the following: state of knowledge on the pathophysiology linking the CNS and mobility, new assessment technologies and statistical approaches, most promising intervention strategies, and/or public information sharing proposals. To facilitate discussion, workshop attendance will be limited to 40 participants and will be by invitation only. However, the outcomes of the workshops will be broadly disseminated as outlined in the dissemination plan. The aims of this conference series are to 1) examine existing evidence from basic, epidemiological, and clinical perspectives and enhance links from animal studies to human investigation of both normal aging and disease at the individual and population level; 2) promote collaborations between basic, epidemiological, and clinical scientists of interrelated disciplines who might not otherwise have an opportunity to work together; 3) identify knowledge gaps, barriers to progress, alternative strategies, and prospects for future inquiry through discussions of emerging research findings; 4) emphasize cutting-edge methodologies for CNS and mobility measures; 5) support involvement from junior investigators, women, minorities, and other underrepresented groups; 6) encourage discussions and exchanges of ideas from workshop participants by providing ample time for interactions and using multimedia presentation formats, including videos; and 7) disseminate findings, discussions, and recommendations to investigators, clinicians, and the public through symposia at the GSA Annual Scientific Meeting, as well as submit coordinated individual papers to a variety of related journals (e.g., Neurology, Gait & Posture, Behavioral and Brain Functions, Movement Disorders, Journal of Gerontology: Medical Sciences, Frontiers in Aging Neuroscience, etc.) for publication.