Changes in Sleep and Cognition in Older Women

老年女性睡眠和认知的变化

• 批准号: 8550740
• 负责人: Katie L Stone
• 金额: $ 59.45万
• 依托单位: CALIFORNIA PACIFIC MED CTR RES INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-15 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8550740
• 关键词: Activities of Daily Living; Address; Advanced Glycosylation End Products; Aging; Biological Markers; Biology; Blood; Brain; Characteristics; Circadian Rhythms; Cognition; Cognitive; Communities; Data; Data Collection; Dementia; Development; Elderly; Electroencephalography; Frequencies; Fructosamine; Functional disorder; Genes; Genetic; Genetic Polymorphism; Health; Heart; Home environment; Hypoxia; Impaired cognition; Incidence; Inflammation; Inflammatory; Insulin Resistance; Leptin; Link; Measurement; Measures; Mediating; Mediator of activation protein; Metabolic; Metabolic Marker; Metabolism; Modeling; Neurons; Nursing Homes; Outcome; Pathway interactions; Performance; Physical Function; Physiological; Polysomnography; Prevention; Quality of life; Reproducibility; Rest; Risk; Role; Serum Markers; Signal Transduction; Sleep; Sleep Apnea Syndromes; Sleep Architecture; Sleep Disorders; Sleep Stages; Sleep disturbances; Specificity; Specimen; Staging; Synapses; Testing; Visual; Woman; Wrist; actigraphy; adiponectin; age related; base; cognitive function; cohort; cost effective; executive function; fall risk; falls; follow-up; functional decline; functional outcomes; genetic risk factor; genome-wide; instrumental activity of daily living; mild cognitive impairment; neuronal circuitry; neuropsychological; novel; older women; pentosidine; pressure; prevent; protective effect; sleep onset; transcription factor

DESCRIPTION (provided by applicant): In the first 5 years of the SOF Sleep and Cognition Study, we utilized objectively measured characteristics of sleep, including wrist actigraphy (n=3,161) and overnight in-home polysomnography (n=461) obtained in primarily community-dwelling older women. Among these women, a subset completed an expanded battery of cognitive function tests five years later and were classified as normal, mild cognitive impairment, or dementia. We demonstrated that several characteristics of sleep (including sleep disordered breathing, sleep quality, and circadian rest-activity rhythms) are associated with risk of incident mild cognitive impairment or dementia, and decline in cognitive function. These novel findings have important implications for the possible prevention and treatment of cognitive impairment. We now propose a cost-effective approach of extending the value of the initial collection of data and specimens supported by the SOF Sleep and Cognition Study to systematically address novel hypotheses focused on the mechanisms linking poor sleep and cognition. In addition, we will extend our follow-up of the initial cohort to identify the independent associations between sleep characteristics and cognitive function with other important age-related outcomes. Thus, the aims of our proposed renewal include: 1) To identify candidate -regions, -genes, and -pathways for both sleep characteristics and cognitive outcomes using recently obtained phenotypic and genome-wide genetic data from the SOF cohort; 2) To test the hypothesis that poor sleep is associated with both cross-sectional and longitudinal changes in metabolic dysfunction among older women, and that metabolic dysfunction mediates associations between poor sleep and cognitive outcomes; 3) To perform spectral analysis of the polysomnography EEG signal to explore associations between novel sleep exposures (including amounts of delta sleep, dissipation rates of slow wave activity, and spindle-frequency activity) with cross-sectional and longitudinal changes in metabolic dysfunction and inflammation, and with onset of cognitive impairment during 5 years of follow-up; and 4) To determine the independent associations of sleep characteristics and cognitive impairment with incident age-related outcomes including functional decline, nursing home placement, and risk of falls. The new information resulting from this renewal application has the potential to inform the development of new treatments to prevent decline in cognitive function in older adults. In addition, we will take advantage of ongoing follow-up for key age-related outcomes in the SOF study to determine whether sleep and cognition are independently related to risk for these conditions. Ultimately, our results may highlight the importance of maintaining healthy sleep characteristics in older adults to prevent the decline in cognitive and physical function associated with aging.

描述（由申请人提供）：在SOF睡眠和认知研究的前5年，我们使用了客观测量的睡眠特征，包括腕动记录仪（n= 3，161）和主要在社区居住的老年妇女中获得的夜间家庭多导睡眠图（n=461）。在这些女性中，一个子集在五年后完成了一系列扩展的认知功能测试，并被归类为正常的轻度认知障碍， 或者痴呆症我们证明了睡眠的几个特征（包括睡眠呼吸障碍、睡眠质量和昼夜休息-活动节律）与事件发生的风险有关。 轻度认知障碍或痴呆，以及认知功能下降。这些新的发现对认知障碍的预防和治疗具有重要意义。我们现在提出了一种具有成本效益的方法，扩展了SOF睡眠和认知研究支持的初始数据和样本收集的价值，以系统地解决新的假设，重点是将睡眠不良和认知联系起来的机制。此外，我们将扩展对初始队列的随访，以确定睡眠特征和认知功能与其他重要年龄相关结果之间的独立关联。因此，我们提出的更新的目的包括：1）使用最近从SOF队列获得的表型和全基因组遗传数据来鉴定睡眠特征和认知结果的候选区域、基因和通路; 2）为了检验睡眠不佳与老年妇女代谢功能障碍的横截面和纵向变化相关的假设，代谢功能障碍介导睡眠不良和认知结果之间的关联; 3）对多导睡眠图EEG信号进行频谱分析，以探索新的睡眠暴露之间的关联（包括δ睡眠量，慢波活动的消散率，和纺锤波频率活动），代谢功能障碍和炎症的横截面和纵向变化，并在5年随访期间发生认知障碍;以及4）确定睡眠特征和认知障碍与年龄相关事件结局（包括功能下降、疗养院安置和福尔斯风险）的独立关联。从这次更新申请中获得的新信息有可能为预防老年人认知功能下降的新治疗方法的开发提供信息。此外，我们将利用SOF研究中关键年龄相关结局的持续随访，以确定睡眠和认知是否与这些疾病的风险独立相关。最终，我们的研究结果可能会突出老年人保持健康睡眠特征的重要性，以防止与衰老相关的认知和身体功能下降。