Changes in Sleep and Cognition in Older Women

老年女性睡眠和认知的变化

• 批准号: 8462717
• 负责人: Katie L Stone
• 金额: $ 67.64万
• 依托单位: CALIFORNIA PACIFIC MED CTR RES INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-15 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8462717
• 关键词: Activities of Daily Living; Address; Advanced Glycosylation End Products; Aging; Biological Markers; Biology; Blood; Brain; Characteristics; Circadian Rhythms; Cognition; Cognitive; Communities; Data; Data Collection; Dementia; Development; Elderly; Electroencephalography; Frequencies; Fructosamine; Functional disorder; Genes; Genetic; Genetic Polymorphism; Health; Heart; Home environment; Hypoxia; Impaired cognition; Incidence; Inflammation; Inflammatory; Insulin Resistance; Leptin; Link; Measurement; Measures; Mediating; Mediator of activation protein; Metabolic; Metabolic Marker; Metabolism; Modeling; Neurons; Nursing Homes; Outcome; Pathway interactions; Performance; Physical Function; Physiological; Polysomnography; Prevention; Quality of life; Reproducibility; Rest; Risk; Role; Serum Markers; Signal Transduction; Sleep; Sleep Apnea Syndromes; Sleep Architecture; Sleep Disorders; Sleep Stages; Sleep disturbances; Specificity; Specimen; Staging; Synapses; Testing; Visual; Woman; Wrist; actigraphy; adiponectin; age related; base; cognitive function; cohort; cost effective; executive function; fall risk; falls; follow-up; functional decline; functional outcomes; genetic risk factor; genome-wide; instrumental activity of daily living; mild neurocognitive impairment; neuronal circuitry; neuropsychological; novel; older women; pentosidine; pressure; prevent; protective effect; sleep onset; transcription factor

DESCRIPTION (provided by applicant): In the first 5 years of the SOF Sleep and Cognition Study, we utilized objectively measured characteristics of sleep, including wrist actigraphy (n=3,161) and overnight in-home polysomnography (n=461) obtained in primarily community-dwelling older women. Among these women, a subset completed an expanded battery of cognitive function tests five years later and were classified as normal, mild cognitive impairment, or dementia. We demonstrated that several characteristics of sleep (including sleep disordered breathing, sleep quality, and circadian rest-activity rhythms) are associated with risk of incident mild cognitive impairment or dementia, and decline in cognitive function. These novel findings have important implications for the possible prevention and treatment of cognitive impairment. We now propose a cost-effective approach of extending the value of the initial collection of data and specimens supported by the SOF Sleep and Cognition Study to systematically address novel hypotheses focused on the mechanisms linking poor sleep and cognition. In addition, we will extend our follow-up of the initial cohort to identify the independent associations between sleep characteristics and cognitive function with other important age-related outcomes. Thus, the aims of our proposed renewal include: 1) To identify candidate -regions, -genes, and -pathways for both sleep characteristics and cognitive outcomes using recently obtained phenotypic and genome-wide genetic data from the SOF cohort; 2) To test the hypothesis that poor sleep is associated with both cross-sectional and longitudinal changes in metabolic dysfunction among older women, and that metabolic dysfunction mediates associations between poor sleep and cognitive outcomes; 3) To perform spectral analysis of the polysomnography EEG signal to explore associations between novel sleep exposures (including amounts of delta sleep, dissipation rates of slow wave activity, and spindle-frequency activity) with cross-sectional and longitudinal changes in metabolic dysfunction and inflammation, and with onset of cognitive impairment during 5 years of follow-up; and 4) To determine the independent associations of sleep characteristics and cognitive impairment with incident age-related outcomes including functional decline, nursing home placement, and risk of falls. The new information resulting from this renewal application has the potential to inform the development of new treatments to prevent decline in cognitive function in older adults. In addition, we will take advantage of ongoing follow-up for key age-related outcomes in the SOF study to determine whether sleep and cognition are independently related to risk for these conditions. Ultimately, our results may highlight the importance of maintaining healthy sleep characteristics in older adults to prevent the decline in cognitive and physical function associated with aging. PUBLIC HEALTH RELEVANCE: We have previously shown that sleep disorders and/or disturbances are related to the risk of developing problems with cognitive function. Our new aims will explore several possible explanations for these findings, including common genetic factors, markers of metabolic function which can be measured in blood, and new measures generated from brain wave data obtained during overnight sleep studies. We will also link sleep and cognitive function with outcomes including falls, functional decline and nursing home placement.

描述（由申请人提供）：在SOF睡眠与认知研究的前5年，我们使用客观测量的睡眠特征，包括腕部活动仪（n= 3161）和夜间在家多导睡眠仪（n=461），主要在社区居住的老年妇女中获得。在这些女性中，一部分人在五年后完成了一系列扩展的认知功能测试，并被归类为正常、轻度认知障碍、