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Targeting the reproductive interactome of the malaria vector Anopheles gambiae

针对疟疾媒介冈比亚按蚊的生殖相互作用组

基本信息

批准号：
8595992
负责人：
Flaminia Catteruccia
金额：
$ 52.21万
依托单位：
HARVARD SCHOOL OF PUBLIC HEALTH
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-05-20 至 2018-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8595992
关键词：
Affect Africa Africa South of the Sahara Anopheles Genus Anopheles gambiae Beds Behavior Biological Biology Bite Blood Chemicals Child Communicable Diseases Copulation Culicidae Deposition Development Employee Strikes Event Female Fertility Future Gene Expression Gene Silencing Genes Genetic Genomics Gland Goals Heart Atrium Human Infection Insecticide Resistance Insecticides Knowledge Malaria Malaria Vaccines Methods Molecular Molecular Genetics Mosquito Control Natural Fertility Organ Output Oviposition Parasites Partner in relationship Pathway interactions Physiology Plasmodium Population Population Density Predisposition Pregnant Women Process Production Prostate Proteins Proteomics RNA Interference Refractory Regulator Genes Reproduction Reproductive Biology Reproductive Physiology Reproductive Process Residual state Risk Role Seminal Sex Behavior Shapes Sterility Techniques Testis Time Tissues Uterus Work Yeasts analog base design egg fighting killings male novel prevent public health relevance reproductive response sex sperm cell success tool transmission process vector vector control vector mosquito weapons yeast two hybrid system

项目摘要

DESCRIPTION (provided by applicant): Malaria is a devastating infectious disease that kills almost a million people each year, mostly pregnant women and young children in Africa. In 2010 there were 200 million people infected with malaria, and 3.3 billion people were at risk of infection. This is half of the world population. Malaria is transmitted by the bite of an infected Anopheles mosquito. In the absence of an effective malaria vaccine, chemical control of the mosquito vector through the use of insecticides remains the best weapon to fight malaria transmission. Insecticide resistance in mosquitoes is however on the rise, and novel methods to control mosquito populations are urgently needed. Anopheles gambiae are the most effective malaria vectors, in part due to a high reproductive rate that maintains large population densities. One of the most promising novel opportunities for vector control is reducing the reproductive output of these mosquitoes by introducing genetic sterility in natural populations. Using molecular, genetic and genomics tools, the "Targeting the reproductive interactome of the malaria vector Anopheles gambiae" project will expand our fundamental understanding of the reproductive biology and physiology of An. gambiae. The project will identify genes and pathways regulating fertility and post-copulatory processes that shape the mosquito reproductive ability. The knowledge generated in this project will contribute to new methods of mosquito control, and eventually to a healthier populace in regions now devastated by malaria.

描述(申请人提供)：疟疾是一种毁灭性的传染病，每年导致近100万人死亡，其中大部分是非洲的孕妇和幼儿。2010年，有2亿人感染疟疾，33亿人面临感染风险。这是世界人口的一半。疟疾是通过被感染的按蚊叮咬传播的。在缺乏有效的疟疾疫苗的情况下，通过使用杀虫剂对蚊子媒介进行化学控制仍然是抗击疟疾传播的最佳武器。然而，蚊子对杀虫剂的抗药性正在上升，迫切需要新的方法来控制蚊子的数量。冈比亚按蚊是最有效的疟疾媒介，部分原因是高繁殖率保持了大量的人口密度。最有希望的病媒控制新机会之一是通过在自然种群中引入遗传不育来减少这些蚊子的繁殖产量。利用分子、遗传学和基因组学工具，针对疟疾媒介冈比亚按蚊的生殖交互作用组的项目将扩大我们对按蚊生殖生物学和生理学的基本理解。冈比亚亚目。该项目将确定调节生育能力和交配后过程的基因和途径，这些基因和途径决定了蚊子的繁殖能力。该项目产生的知识将有助于蚊子控制的新方法，并最终有助于目前遭受疟疾蹂躏的地区的更健康的民众。