ROLE OF THE SACCADIC EYE-MOVEMENT COROLLARY DISCHARGE IN STABLE VISUAL PERCEPTION

眼跳眼动伴随放电在稳定视觉感知中的作用

• 批准号: 8549254
• 负责人: Wilsaan M Joiner
• 金额: $ 23.04万
• 依托单位: GEORGE MASON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-30 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8549254
• 关键词: Affect; Area; Brain; Characteristics; Data; Defect; Detection; Development; Diagnosis; Diagnostic; Disease; Environment; Esthesia; Financial compensation; Goals; Health; Human; Judgment; Knowledge; Link; Maintenance; Motor; Movement; Neuroanatomy; Notification; Outcome; Outcomes Research; Patients; Perception; Perceptual Disorders; Play; Positioning Attribute; Process; Property; Proprioception; Psychophysics; Research; Retina; Role; Saccades; Sampling; Schizophrenia; Sensory; Signal Transduction; Source; System; Testing; Time; Update; Variant; Visual; Visual Fields; Visual Perception; Work; base; cognitive function; design; human subject; innovation; nervous system disorder; prevent; rapid eye movement; relating to nervous system; research study; therapy design; transmission process; treatment strategy; visual feedback; visual process; visual processing

PROJECT SUMMARY Stable visual perception is maintained despite the frequent saccadic eye-movements that disrupt the visual input. One hypothesis for this compensation is that advanced knowledge of the impending saccade is provided by an internal copy, a corollary discharge (CD) signal, of the motor command. This copy is utilized to distinguish self-generated sensations from environmental disturbances and reflects properties of the original motor command. However, the influence these mirrored characteristics exert in determining the source of a disturbance and its impact on visual perception is currently unknown. The research objective of this application is to determine the consequences of CD variability on the ability to make accurate perceptual judgments of trans-saccadic changes in the visual scene, and establish that defects in CD transmission underlie the visual perceptual disorders in neurological disease. The central hypothesis of this research is that (1) the CD of saccadic eye-movements of different amplitudes and directions reflect the properties of the original motor command and (2) patients with CD transmission disruption, such as in Schizophrenia, will demonstrate a reduced ability to perceive trans-saccadic visual scene variations. The research uses human psychophysics and the known neuroanatomy of the saccadic eye-movement system to dissect the way the brain continuously incorporates the changing sensory information that results from our own actions into a stable visual percept. The hypothesis of the application has been formulated on the basis of strong preliminary data that show the ability to utilize CD to detect trans-saccadic visual scene alterations in normal human subjects weakens with increasing variance in the CD signal and is also influenced by the direction of the saccadic eye-movement, as predicted from the source of the CD and motor command. The long-term goal of the research is to understand the role of corollary discharge in visual perception and movement control with the objective of contributing to the diagnosis and treatment of diseases that result from CD transmission deficits. The expected outcomes of the research is to provide evidence that perceptual judgments.; of trans-saccadic changes is influenced by the variability reflected in the CD signal, and that this detection ability is diminished when CD transmission is degraded in Schizophrenia. This contribution is significant because in addition to diagnostics, the majority of the internal signals in the brain that do not represent sensory or motor information are presently inaccessible, and it is likely that diseases that impair higher cognitive function affect these circuits, as in Schizophrenia. CD is one of the few internal signals that is experimentally accessible and, through its study, an enhanced understanding of these signals and their transmission can be achieved.

尽管经常会破坏视觉输入，但仍保持了项目摘要稳定的视觉感知。该补偿的一种假设是，即将到来的扫视的先进知识由电动机命令的内部副本（推论放电（CD）信号）提供。该副本用于区分自我生成的感觉和环境干扰，并反映原始电动机命令的属性。但是，这些镜像特征在确定干扰源及其对视觉感知的影响方面的影响尚不清楚。该应用的研究目的是确定CD变异性对视觉场景中反式 - 学术变化的准确感知判断的能力的后果，并确定CD传播的缺陷是神经系统疾病中视觉感知障碍的基础。这项研究的核心假设是（1）不同振幅和方向的Saccadic眼动症状的CD反映了原始运动命令的特性，以及（2）患有CD传递破坏的患者，例如在精神分裂症中，将证明感知到感知的反式 - 射频视觉场景变化的能力。该研究使用人类的心理物理学和Saccadic眼动系统的已知神经解剖学来剖析大脑不断地融入从我们自己的动作中导致的不断变化的感觉信息的方式，使其成为稳定的视觉感知。该应用的假设是基于强大的初步数据提出的，该数据表明，正常人受试者中使用CD的能力检测到反式 - 响应视觉场景的改变会随着CD信号的差异的增加而削弱，并且还受SACCADIC焦虑感的方向的影响，如CD和运动命令的源头所预测的那样。该研究的长期目标是了解推论排放在视觉感知和运动控制中的作用，目的是有助于诊断和治疗CD传播缺陷引起的疾病。这项研究的预期结果是提供证据表明判断。反式 - 影响的变化受CD信号反映的变异性的影响，当精神分裂症中CD传播降解时，这种检测能力会降低。这种贡献很重要，因为除了诊断外，大脑中不代表感官或运动信息的大多数内部信号目前是无法访问的，并且可能损害更高认知功能的疾病会影响这些回路，如精神分裂症。 CD是实验可访问的少数内部信号之一，通过其研究，可以增强对这些信号及其传输的了解。