ROLE OF THE SACCADIC EYE-MOVEMENT COROLLARY DISCHARGE IN STABLE VISUAL PERCEPTION

眼跳眼动伴随放电在稳定视觉感知中的作用

• 批准号: 8549254
• 负责人: Wilsaan M Joiner
• 金额: $ 23.04万
• 依托单位: GEORGE MASON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-30 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8549254
• 关键词: Affect; Area; Brain; Characteristics; Data; Defect; Detection; Development; Diagnosis; Diagnostic; Disease; Environment; Esthesia; Financial compensation; Goals; Health; Human; Judgment; Knowledge; Link; Maintenance; Motor; Movement; Neuroanatomy; Notification; Outcome; Outcomes Research; Patients; Perception; Perceptual Disorders; Play; Positioning Attribute; Process; Property; Proprioception; Psychophysics; Research; Retina; Role; Saccades; Sampling; Schizophrenia; Sensory; Signal Transduction; Source; System; Testing; Time; Update; Variant; Visual; Visual Fields; Visual Perception; Work; base; cognitive function; design; human subject; innovation; nervous system disorder; prevent; rapid eye movement; relating to nervous system; research study; therapy design; transmission process; treatment strategy; visual feedback; visual process; visual processing

PROJECT SUMMARY Stable visual perception is maintained despite the frequent saccadic eye-movements that disrupt the visual input. One hypothesis for this compensation is that advanced knowledge of the impending saccade is provided by an internal copy, a corollary discharge (CD) signal, of the motor command. This copy is utilized to distinguish self-generated sensations from environmental disturbances and reflects properties of the original motor command. However, the influence these mirrored characteristics exert in determining the source of a disturbance and its impact on visual perception is currently unknown. The research objective of this application is to determine the consequences of CD variability on the ability to make accurate perceptual judgments of trans-saccadic changes in the visual scene, and establish that defects in CD transmission underlie the visual perceptual disorders in neurological disease. The central hypothesis of this research is that (1) the CD of saccadic eye-movements of different amplitudes and directions reflect the properties of the original motor command and (2) patients with CD transmission disruption, such as in Schizophrenia, will demonstrate a reduced ability to perceive trans-saccadic visual scene variations. The research uses human psychophysics and the known neuroanatomy of the saccadic eye-movement system to dissect the way the brain continuously incorporates the changing sensory information that results from our own actions into a stable visual percept. The hypothesis of the application has been formulated on the basis of strong preliminary data that show the ability to utilize CD to detect trans-saccadic visual scene alterations in normal human subjects weakens with increasing variance in the CD signal and is also influenced by the direction of the saccadic eye-movement, as predicted from the source of the CD and motor command. The long-term goal of the research is to understand the role of corollary discharge in visual perception and movement control with the objective of contributing to the diagnosis and treatment of diseases that result from CD transmission deficits. The expected outcomes of the research is to provide evidence that perceptual judgments.; of trans-saccadic changes is influenced by the variability reflected in the CD signal, and that this detection ability is diminished when CD transmission is degraded in Schizophrenia. This contribution is significant because in addition to diagnostics, the majority of the internal signals in the brain that do not represent sensory or motor information are presently inaccessible, and it is likely that diseases that impair higher cognitive function affect these circuits, as in Schizophrenia. CD is one of the few internal signals that is experimentally accessible and, through its study, an enhanced understanding of these signals and their transmission can be achieved.

尽管频繁的眼球跳跃性运动干扰了视觉输入，但稳定的视觉知觉仍能保持。这种补偿的一种假设是，对即将到来的眼跳的预先了解是由运动指令的内部副本，即必然放电（CD）信号提供的。这个副本被用来区分自我产生的感觉和环境干扰，并反映了原始运动命令的特性。然而，这些镜像特征在确定干扰来源及其对视觉感知的影响方面的影响目前尚不清楚。本应用程序的研究目的是确定CD变异性对视觉场景跨眼球变化的准确感知判断能力的影响，并确定CD传输缺陷是神经系统疾病中视觉感知障碍的基础。本研究的中心假设是：(1)不同幅度和方向的跳眼运动的CD反映了原始运动命令的特性；(2)CD传输中断的患者，如精神分裂症患者，将表现出感知跨跳眼视觉场景变化的能力下降。这项研究利用人类心理物理学和已知的眼动系统的神经解剖学来剖析大脑如何不断地将我们自己的行为产生的不断变化的感觉信息整合到一个稳定的视觉感知中。该应用的假设是在强有力的初步数据的基础上制定的，这些数据表明，利用CD检测正常人类受试者跨扫视场景变化的能力随着CD信号变化的增加而减弱，并且还受到从CD来源和运动命令预测的扫视眼运动方向的影响。该研究的长期目标是了解伴随放电在视觉感知和运动控制中的作用，目的是为诊断和治疗由CD传递缺陷引起的疾病做出贡献。本研究的预期结果是为感性判断提供证据。跨跳细胞变化的检测受到CD信号所反映的变异性的影响，当精神分裂症患者的CD传输减弱时，这种检测能力就会减弱。这一贡献意义重大，因为除了诊断之外，大脑中大多数不代表感觉或运动信息的内部信号目前是无法获取的，而且很可能损害高级认知功能的疾病会影响这些回路，就像精神分裂症一样。CD是为数不多的可以通过实验获得的内部信号之一，通过对它的研究，可以加强对这些信号及其传输的理解。