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Digital holographic adaptive optics for retinal imaging without wavefront sensor

无需波前传感器的视网膜成像数字全息自适应光学器件

基本信息

批准号：
8515426
负责人：
MYUNG K KIM
金额：
$ 13.74万
依托单位：
UNIVERSITY OF SOUTH FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-01 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8515426
关键词：
Animals Area Automobile Driving Budgets Collaborations Computer software Consultations Cornea Crystalline Lens Development Diagnosis Eye Feedback Financial compensation Glaucoma Goals Holography Human Image Imaging Techniques Imaging technology Individual Institutes Knowledge Lead Light Lighting Maintenance Measurement Measures Medical Methods Modeling Noise Operative Surgical Procedures Ophthalmology Optics Performance Phase Photoreceptors Preparation Process Protocols documentation Research Research Personnel Research Project Grants Resolution Retina Retinal Retinal Degeneration Scheme Series Signal Transduction Specimen Speed Structure Surface System Techniques Technology Three-Dimensional Imaging Time Work adaptive optics base charge coupled device camera cost design digital improved in vivo innovation instrument novel optical imaging programs research study sensor simulation software development technique development

项目摘要

DESCRIPTION (provided by applicant): A new adaptive optics (AO) retinal imaging system is proposed that is based on the principles of digital holography and dispenses with the wavefront sensor and wavefront modulator of conventional AO system. Digital holography (DH) is an emergent new imaging technology that gives direct numerical access to the phase of the optical field, thus allowing precise control and manipulation of the optical field. Incorporation of DH in an ophthalmic imaging system can lead to versatile imaging capabilities at substantially reduced complexity and cost of the instrument. A typical conventional AO system includes several critical hardware pieces: spatial light modulator, lenslet array, and a second CCD camera in addition to the camera for imaging. The proposed digital holographic adaptive optics (DHAO) system replaces these hardware components with numerical processing for wavefront measurement and compensation of aberration through the principles of digital holography. The wavefront sensing and correction by DHAO have almost the full resolution of the CCD camera. It is inherently faster than conventional AO because it does not involve feedback and iteration, and the dynamic range of deformation measurement is essentially unlimited. DHAO may offer additional novel imaging capabilities such as wider field of view of the retina, automatic focus over the entire FOV of curved retinal surface, topography of the retinal surface, and 3D imaging of intraocular debris distribution. The proposed project will start with a set of experiments designed to demonstrate the principles of wavefront sensing and aberration compensation by DHAO and to measure and characterize basic imaging parameters such as the resolution, point spread function, light budget, signal and noise, and dynamic range. Then a self- contained benchtop instrument is to be constructed, sufficiently compact and robust for systematic imaging experiments with realistic eye models and excised animal eyes. Development of a suite of software programs is an important part of the construction. A series of imaging experiments will be carried out to evaluate the imaging capabilities of the DHAO instrument and to develop several special imaging techniques, especially to highlight some of the unique capabilities of the proposed system. The proposed DHAO instrument will provide high resolution images of retina and other structures as well as a number of novel imaging capabilities, but with significantly lower complexity and cost compared to current technology. This will make high-resolution ophthalmic imaging available and applicable to a wider range of diagnosis and treatments in ophthalmology, such as in retinal degeneration, glaucoma, and refractive surgery.

描述（由申请人提供）：提出了一种新的自适应光学（AO）视网膜成像系统，其基于数字全息术的原理并且省去了常规AO系统的波前传感器和波前调制器。数字全息术是一种新兴的成像技术，它可以对光场的相位进行直接的数值计算，从而实现对光场的精确控制和操纵。在眼科成像系统中结合DH可以在显著降低仪器的复杂性和成本的情况下产生多功能成像能力。一个典型的传统AO系统包括几个关键的硬件部分：空间光调制器，小透镜阵列，和第二个CCD相机除了用于成像的相机。提出的数字全息自适应光学（DHAO）系统取代这些硬件组件与数字处理波前测量和补偿的像差，通过数字全息的原则。DHAO的波前传感和校正几乎具有CCD相机的全分辨率。它本质上比传统AO更快，因为它不涉及反馈和迭代，并且变形测量的动态范围基本上是无限的。DHAO可以提供额外的新颖成像能力，例如视网膜的更宽视野、在弯曲视网膜表面的整个FOV上的自动聚焦、视网膜表面的形貌以及眼内碎片分布的3D成像。拟议的项目将从一系列实验开始，这些实验旨在演示DHAO的波前传感和像差补偿原理，并测量和表征基本成像参数，如分辨率、点扩散函数、光预算、信号和噪声以及动态范围。然后，要构建一个独立的台式仪器，该仪器足够紧凑和鲁棒，用于使用逼真的眼睛模型和切除的动物眼睛进行系统的成像实验。开发一套软件程序是建设的重要组成部分。将进行一系列成像实验，以评估DHAO仪器的成像能力，并开发几种特殊的成像技术，特别是突出所提出的系统的一些独特的能力。拟议的DHAO仪器将提供视网膜和其他结构的高分辨率图像以及许多新的成像能力，但与当前技术相比，复杂性和成本显着降低。这将使高分辨率眼科成像成为可能，并适用于更广泛的眼科诊断和治疗，如视网膜变性、青光眼和屈光手术。