2013 Apoptotic Cell Recognition & Clearance Gordon Research Conference and Gordon

2013 凋亡细胞识别

• 批准号: 8510853
• 负责人: Nathalie Claudine Franc
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8510853
• 关键词: Address; Adult; Animal Model; Apoptosis; Apoptotic; Area; Autoimmune Diseases; Autoimmunity; Biochemistry; Biological Process; Cells; Cellular biology; Cessation of life; Chronic; Communities; Data; Defect; Development; Developmental Biology; Disease; Environment; Excision; Failure; Feedback; Fishes; Fund Raising; Funding; Future; Genetic; Health; Homeostasis; Human; Human body; Immune; Immunization; Immunology; Individual; Infection; Inflammation; Inflammatory; International; Lead; Lupus; Maintenance; Malignant Neoplasms; Minority; Molecular; Molecular Biology; Molecular Genetics; Morphogenesis; Mus; Nerve Degeneration; Neurobiology; Neurodegenerative Disorders; New England; Organ; Organism; Participant; Phagocytes; Phagocytosis; Pharmacology; Play; Postdoctoral Fellow; Process; Request for Applications; Research; Research Personnel; Research Project Grants; Resistance; Resolution; Retinal Degeneration; Scientist; Series; Time; Tissues; United States; Universities; Virus; Woman; Work; abstracting; base; career development; design; fighting; fly; graduate student; human disease; meetings; neoplastic cell; neurogenesis; novel therapeutics; pathogen; peer; posters; prevent; programs; public health relevance; symposium; tissue repair; tumor immunology; tumorigenesis

DESCRIPTION (provided by applicant): About 50-200 billion of our cells die daily by apoptosis or programmed cell death in the human body. The mechanisms of apoptosis have been extensively studied, but those of the elimination of apoptotic cells are much less understood. Apoptotic cells are rapidly engulfed and digested by their neighbors or by professional phagocytes in a process known as phagocytosis, clearance or efferocytosis. During development this process plays a key role in tissue morphogenesis and renewal. It also allows for the maintenance of tissue homeostasis in adults and promotes the resolution of inflammation. Failure to clear apoptotic cells can result in developmental defects, chronic inflammatory disorders, autoimmune and neurodegenerative diseases. For example, it has been associated with Lupus, a chronic inflammatory autoimmune disease, and with retinal degeneration. Dying cells can be cleared before completion of their programmed death, and failure in this process may result in cancer. A thorough understanding of efferocytosis is essential to design new therapies to prevent or treat chronic inflammation, autoimmune and neurodegenerative diseases, and cancer. Some of the molecular mechanisms of apoptotic cell clearance are shared with those of pathogen clearance, and thus studying efferocytosis will also lead to new therapies to fight infections. This is critical since pathogens are becoming resistant to current treatments. At this 2013 Apoptotic Cell Recognition & Clearance Gordon Research Conference and its associated Gordon Research Seminar to be held from June 22-28 at the University of New England, Biddeford, ME, we will discuss the latest advances made in our understanding of the molecular mechanisms of efferocytosis in all model organisms, from worm, fly, fish and mouse, to mammalian (including human) cells in the context of both healthy and disease states. This conference, held every other year since 2003, will be the sixth in its series and is the only regular international meeting in this field. This conference will bring together researchers with expertise in biochemistry, genetics, cell, molecular and developmental biology, neurobiology, immunology and pharmacology, as well as clinicians who are at the forefront of the field. Post-docs and graduate students will have the opportunity to orally present their work and network amongst themselves at the GRS. This GRS will prepare and encourage them to attend and participate at the GRC, where they can also present their work in poster format to discuss and exchange ideas with the leaders in the field. The best GRS speakers and some GRC poster presenters will be selected for short talks at the GRC, a much sought-after exposure and opportunity for feedback from their peers.

描述（由申请人提供）：在人体中，每天约有500 - 2000亿个细胞通过细胞凋亡或程序性细胞死亡而死亡。细胞凋亡的机制已被广泛研究，但对凋亡细胞的消除机制的了解却少得多。凋亡细胞被其邻近细胞或专职吞噬细胞迅速吞噬和消化，这一过程称为吞噬作用、清除作用或吞噬作用。在发育过程中，这一过程在组织形态发生和更新中起着关键作用。它还允许维持成人的组织稳态，并促进炎症的消退。未能清除凋亡细胞可导致发育缺陷、慢性炎症性疾病、自身免疫性疾病和神经退行性疾病。例如，它与狼疮（一种慢性炎症性自身免疫性疾病）和视网膜变性有关。垂死的细胞可以在完成程序性死亡之前被清除，这一过程的失败可能导致癌症。对红细胞增多症的深入了解对于设计新的治疗方法来预防或治疗慢性炎症、自身免疫性和神经退行性疾病以及癌症至关重要。凋亡细胞清除的一些分子机制与病原体清除的分子机制是相同的，因此研究红细胞增多症也将导致对抗感染的新疗法。这一点至关重要，因为病原体对目前的治疗方法产生了抗药性。 在这个2013年凋亡细胞识别和清除戈登研究会议及其相关的戈登研究研讨会将于6月22日至28日在新英格兰，比德福德，ME大学举行，我们将讨论我们在所有模式生物中对细胞凋亡分子机制的理解方面取得的最新进展，从蠕虫，苍蝇，鱼和老鼠，哺乳动物（包括人）细胞在健康和疾病状态的情况下。 自2003年以来每隔一年举行一次的这次会议将是其系列会议中的第六次 是该领域唯一的定期国际会议。本次会议将汇集具有生物化学，遗传学，细胞，分子和发育生物学，神经生物学，免疫学和药理学专业知识的研究人员，以及处于该领域前沿的临床医生。博士后和研究生将有机会在GRS口头介绍他们的工作和网络。该GRS将准备并鼓励他们参加并参加GRC，在那里他们还可以以海报形式展示他们的工作，与该领域的领导人讨论和交流想法。最好的GRS演讲者和一些GRC海报演示者将被选中在GRC进行简短的演讲，这是一个非常受欢迎的曝光和来自同行反馈的机会。