2013 Apoptotic Cell Recognition & Clearance Gordon Research Conference and Gordon

描述(申请人提供)：我们的细胞每天约有500-2000亿死于人体内的细胞凋亡或程序性细胞死亡。细胞凋亡的机制已被广泛研究，但对消除细胞凋亡的机制知之甚少。在被称为吞噬、清除或泡出的过程中，凋亡细胞被其邻居或专业吞噬细胞迅速吞噬和消化。在发育过程中，这一过程在组织形态发生和更新中起着关键作用。它还可以维持成人的组织动态平衡，并促进炎症的消退。未能清除凋亡细胞会导致发育缺陷、慢性炎症性疾病、自身免疫性疾病和神经退行性疾病。例如，它与狼疮，一种慢性炎症性自身免疫性疾病，以及视网膜退化有关。垂死的细胞可以在它们的程序性死亡完成之前被清除，如果这个过程失败，可能会导致癌症。彻底了解泡腾作用对于设计预防或治疗慢性炎症、自身免疫性和神经退行性疾病以及癌症的新疗法至关重要。一些凋亡细胞清除的分子机制与病原体清除的分子机制是相同的，因此研究泡泡吞噬作用也将导致对抗感染的新疗法。这一点至关重要，因为病原体正在对当前的治疗方法产生抗药性。2013年细胞凋亡识别与清除戈登研究会议及其相关的戈登研究研讨会将于6月22日至28日在新英格兰大学比德福德举行，我们将讨论在所有模式生物中，从蠕虫、苍蝇、鱼和老鼠到哺乳动物(包括人类)细胞在健康和疾病状态下的泡泡吞噬分子机制的最新进展。自2003年以来，该会议每隔一年举行一次，这将是该系列会议的第六届 也是该领域唯一的定期国际会议。本次会议将汇集在生物化学、遗传学、细胞、分子和发育生物学、神经生物学、免疫学和药理学方面具有专业知识的研究人员，以及处于该领域前沿的临床医生。博士后和研究生将有机会在GRS口头介绍他们的工作和他们之间的网络。这份GRS将准备并鼓励他们参加GRC，在那里他们也可以用海报的形式展示他们的工作，与该领域的领导者讨论和交流想法。最好的GRS演讲者和一些GRC海报演讲者将被选为GRC的简短演讲，这是一个非常受欢迎的机会，可以从他们的同行那里获得反馈。

DESCRIPTION (provided by applicant): About 50-200 billion of our cells die daily by apoptosis or programmed cell death in the human body. The mechanisms of apoptosis have been extensively studied, but those of the elimination of apoptotic cells are much less understood. Apoptotic cells are rapidly engulfed and digested by their neighbors or by professional phagocytes in a process known as phagocytosis, clearance or efferocytosis. During development this process plays a key role in tissue morphogenesis and renewal. It also allows for the maintenance of tissue homeostasis in adults and promotes the resolution of inflammation. Failure to clear apoptotic cells can result in developmental defects, chronic inflammatory disorders, autoimmune and neurodegenerative diseases. For example, it has been associated with Lupus, a chronic inflammatory autoimmune disease, and with retinal degeneration. Dying cells can be cleared before completion of their programmed death, and failure in this process may result in cancer. A thorough understanding of efferocytosis is essential to design new therapies to prevent or treat chronic inflammation, autoimmune and neurodegenerative diseases, and cancer. Some of the molecular mechanisms of apoptotic cell clearance are shared with those of pathogen clearance, and thus studying efferocytosis will also lead to new therapies to fight infections. This is critical since pathogens are becoming resistant to current treatments. At this 2013 Apoptotic Cell Recognition & Clearance Gordon Research Conference and its associated Gordon Research Seminar to be held from June 22-28 at the University of New England, Biddeford, ME, we will discuss the latest advances made in our understanding of the molecular mechanisms of efferocytosis in all model organisms, from worm, fly, fish and mouse, to mammalian (including human) cells in the context of both healthy and disease states. This conference, held every other year since 2003, will be the sixth in its series and is the only regular international meeting in this field. This conference will bring together researchers with expertise in biochemistry, genetics, cell, molecular and developmental biology, neurobiology, immunology and pharmacology, as well as clinicians who are at the forefront of the field. Post-docs and graduate students will have the opportunity to orally present their work and network amongst themselves at the GRS. This GRS will prepare and encourage them to attend and participate at the GRC, where they can also present their work in poster format to discuss and exchange ideas with the leaders in the field. The best GRS speakers and some GRC poster presenters will be selected for short talks at the GRC, a much sought-after exposure and opportunity for feedback from their peers.