FASEB SRC on Epigenetics, Chromatin & Transcription

描述(由申请人提供)：本申请旨在为2013年6月16-21日在巴哈马拿骚举行的FASEB夏季“表观遗传学、染色质和转录”会议提供部分资金。这次会议的主要目标是提供一个论坛，将几个学科聚集在一起，处理发生在整个基因组中的表观遗传变化，以响应信号(发育和环境)和疾病。这次会议将为对这些重要问题感兴趣的研究人员提供一个亟需的场所，以便他们能够审查这一不断增长的领域的关键发展，并促进和启发新的研究方向。重要的是，表观遗传学研究涵盖了各种各样的专业，从研究表观遗传背后的基础生物学到专注于细胞内和细胞外信号的影响。这次会议在努力将这些多个方面结合在一起方面是独一无二的。自1991年成立以来，FASEB会议定期吸引了一批强大的国际与会者和演讲者，实际上，它是FASEB最成功的会议之一。此外，为了反映这一动态领域，会议的重点不断演变。今年，我们强调基因组方法，以了解瞬时信号如何在生物体的正常发育和疾病中导致持续的染色质调节状态。此外，为了扩大兴趣领域，我们还包括了一组新的发言者，重点关注非编码RNA及其对染色质和基因组表观遗传特征的影响。最后，我们计划通过从摘要中挑选8-12名额外的演讲者，特别是有前途的博士后科学家，使演讲者群体显著多样化。会议的具体目标是：1.对基因表达的表观遗传调控领域进行全面和批判性的审查。会议从表观遗传性的基础生物学延伸到其他关键领域，如基因组和系统方法、非编码RNA、易感性窗口(例如发育生物学和干细胞的使用)以及疾病领域(例如环境暴露和癌症)。2.通过介绍和热烈讨论新的突破，推动这一不断扩大的领域的前沿研究。3.汇聚各级资深和初级科学家，鼓励广泛讨论，促进青年科学家的发展。

DESCRIPTION (provided by applicant): This application seeks partial funding for a FASEB Summer Conference on "Epigenetics Chromatin & Transcription", to be held June 16-21, 2013 in Nassau, Bahamas. The major goal of this conference is provide a forum to bring together several disciplines addressing the epigenetic changes that occur across the genome in response to signals (developmental and environmental) and in disease. This meeting will provide a much needed venue for researchers whose interests converge on these important questions, so that they can review key developments in this growing field, and to foster and inspire new research directions. Importantly, epigenetic research encompasses a wide diversity of specialties, ranging from those studying the fundamental biology underlying epigenetic inheritance to those focusing on the influences of intra- and extra-cellular signals. This meeting is unique in endeavoring to bring together these multiple aspects. From its inception in 1991, this FASEB conference has regularly attracted a strong international group of attendees and speakers, and, indeed, is one of the most consistently successful FASEB meetings. Moreover, to reflect this dynamic field, the focus of the meeting continually evolves. This year, we are emphasizing genomic approaches to understanding how transient signals can lead to persistent chromatin regulatory states in both the normal development of an organism and in disease. In addition, to expand the interest area, we have included a new cohort of speakers focusing on non-coding RNAs and their influence on chromatin and epigenetic features of the genome. Finally, we plan to markedly diversify the speaker group by selecting 8-12 additional speakers, especially promising post-doctoral scientists, from abstracts. The specific objectives of the meeting are: 1.To provide a comprehensive and critical review of the field of epigenetic regulation of gene expression. The meeting extends from basic biology of epigenetic heritability into other key areas, such as genomic and systems approaches, non-coding RNAs, windows of susceptibility (e.g. developmental biology and the use of stem cells), as well as disease areas (e.g. environmental exposures and cancer). 2. To advance cutting-edge research in this expanding field, through presentation and lively discussion of novel breakthroughs. 3. To bring together senior and junior scientists of all ranks, encouraging wide- ranging discussions and promoting the development of young scientists.