Epigenetics, environmental exposure, and reproduction in the Collaborative Cross
协同杂交中的表观遗传学、环境暴露和繁殖
基本信息
- 批准号:8478110
- 负责人:
- 金额:$ 8.79万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-06-01 至 2014-05-31
- 项目状态:已结题
- 来源:
- 关键词:Adverse effectsAllelesAnalysis of VarianceAnimal ModelBiologicalBiological AssayBiological ModelsChemical ExposureChromosome MappingComplexDNA MethylationDataDiethylstilbestrolEndocrine DisruptorsEnvironmentEnvironmental ExposureEpigenetic ProcessEquilibriumEstrogensExposure toGene ExpressionGene Expression RegulationGenesGeneticGenetic ModelsGenetic VariationGenomeGoalsHealthHumanInbred MouseInbred StrainInbred Strains MiceInbreedingIndividualKnowledgeLinkMale Genital OrgansMapsMeasuresMentorsMethodsModelingMolecularMolecular BiologyMolecular WeightMusNeonatalPathway interactionsPhenotypePhysiologicalPhysiologyPlayPopulationPopulation ControlPopulation HeterogeneityPostdoctoral FellowPredispositionPropertyProtocols documentationQuantitative Trait LociRandomizedReproducibilityReproductionReproductive PhysiologyReproductive systemResearchResearch PersonnelResourcesRoleSeriesSperm Count ProcedureSystemTestingTestisTissuesTranslatingVariantbisulfiteconsumer productgene environment interactioninsightmRNA Expressionmalepublic health relevancereproductiveresponsetraitxenoestrogen
项目摘要
DESCRIPTION (provided by applicant)
The proposed research is a systems genetics approach to characterize the complex relationships between genetic variation, epigenetic regulation, gene expression, male reproductive physiology, and environmental exposure. To accomplish this goal, the investigators will leverage the power of diverse inbred mouse strains and the Collaborative Cross, a mouse reference population that has ideal properties for systems genetics. To identify gene-by-environment (GXE) interactions, the investigators will perturb the reproductive system with the powerful estrogen diethylstilbestrol (DES) and phenotype identical exposed and control populations. The investigators will measure DNA methylation, mRNA expression, and reproductive traits with the purpose of modeling genetic effects and GXE across three levels of genome function. This research will produce new biological knowledge of the genetic networks underlying the reproductive system, DES function at the molecular level, and genes underlying DES sensitivity.
描述(由申请人提供)
这项研究是一种系统遗传学方法,旨在描述遗传变异、表观遗传调控、基因表达、男性生殖生理和环境暴露之间的复杂关系。为了实现这一目标,研究人员将利用各种近交系小鼠品系和合作杂交的力量,合作杂交是具有系统遗传学理想特性的小鼠参考种群。为了确定基因与环境(GxE)的相互作用,研究人员将用强大的雌激素己烯雌酚(DES)扰乱生殖系统,并将暴露人群和对照人群的表型相同。研究人员将测量DNA甲基化、mRNA表达和生殖特征,目的是在基因组功能的三个水平上模拟遗传效应和GxE。这项研究将产生关于生殖系统潜在的遗传网络、DES在分子水平上的功能以及DES敏感性的基因的新的生物学知识。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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David Lawrence Aylor其他文献
David Lawrence Aylor的其他文献
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{{ truncateString('David Lawrence Aylor', 18)}}的其他基金
A New Model for Elucidating the Genetic Mechanisms of Hybrid Male Sterility in House Mice
阐明家鼠杂交雄性不育遗传机制的新模型
- 批准号:
10709906 - 财政年份:2022
- 资助金额:
$ 8.79万 - 项目类别:
A New Model for Elucidating the Genetic Mechanisms of Hybrid Male Sterility in House Mice
阐明家鼠杂交雄性不育遗传机制的新模型
- 批准号:
10592916 - 财政年份:2022
- 资助金额:
$ 8.79万 - 项目类别:
Systems Toxicogenomics of Endocrine Disrupting Chemicals in Brain
脑内内分泌干扰化学物质的系统毒物基因组学
- 批准号:
9098205 - 财政年份:2016
- 资助金额:
$ 8.79万 - 项目类别:
Systems Toxicogenomics of Endocrine Disrupting Chemicals in Brain
脑内内分泌干扰化学物质的系统毒物基因组学
- 批准号:
9567637 - 财政年份:2016
- 资助金额:
$ 8.79万 - 项目类别:
Epigenetics, environmental exposure, and reproduction in the Collaborative Cross
协同杂交中的表观遗传学、环境暴露和繁殖
- 批准号:
8831815 - 财政年份:2014
- 资助金额:
$ 8.79万 - 项目类别:
Epigenetics, environmental exposure, and reproduction in the Collaborative Cross
协同杂交中的表观遗传学、环境暴露和繁殖
- 批准号:
9063160 - 财政年份:2014
- 资助金额:
$ 8.79万 - 项目类别:
Epigenetics, environmental exposure, and reproduction in the Collaborative Cross
协同杂交中的表观遗传学、环境暴露和繁殖
- 批准号:
8281087 - 财政年份:2012
- 资助金额:
$ 8.79万 - 项目类别:
System Genetics of Male Infertility in the Collaborative Cross
合作杂交中男性不育的系统遗传学
- 批准号:
8003213 - 财政年份:2010
- 资助金额:
$ 8.79万 - 项目类别:
System Genetics of Male Infertility in the Collaborative Cross
合作杂交中男性不育的系统遗传学
- 批准号:
8205432 - 财政年份:2010
- 资助金额:
$ 8.79万 - 项目类别:
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