System Genetics of Male Infertility in the Collaborative Cross

合作杂交中男性不育的系统遗传学

• 批准号: 8003213
• 负责人: David Lawrence Aylor
• 金额: $ 5.05万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8003213
• 关键词: Affect; Biology; Breeding; Chromosome Mapping; Complex; Couples; Environmental Risk Factor; Extinction (Psychology); Fertility; Genes; Genetic; Genetic Variation; Health; Human; Individual; Infertility; Inherited; Male Infertility; Methods; Mus; Parents; Population; Population Heterogeneity; Process; Reporting; Research; Sperm Count Procedure; Structure; System; Testis; combinatorial; design; fitness; male; mouse model; offspring; public health relevance; reproductive; trait

DESCRIPTION (provided by applicant): The paradox of the genetics underlying infertility is that infertile individuals must have descended from fertile parents. Nonetheless, previous studies have attributed infertility in part to inherited genetic factors. As is the case with many pervasive human health conditions, this results from combinatorial effects of multiple genes, environmental factors and their interactions. Such small effects and interactions are often difficult to detect in both human populations and mouse models. The proposed research will identify genetic variation underlying male infertility using a new mouse population called the Collaborative Cross (CC). The CC is designed to facilitate mapping genes associated with complex traits. During the breeding process, up to 50% of incipient lines stop producing offspring and are declared extinct, and male infertility is a major mechanism of this extinction. This large and diverse population of infertile male mice can be used to better understand the biology and genetics of male infertility and its associated reproductive parameters such as sperm count and testis structure. This project is also valuable to develop new methods that apply to the CC population.

描述（由申请人提供）：不育症的遗传学的悖论是，不育个人必须是肥沃的父母的后裔。尽管如此，先前的研究部分归因于遗传因素的一部分。与许多普遍的人类健康状况一样，这是由多个基因，环境因素及其相互作用的组合作用引起的。在人类和小鼠模型中，这种微小的影响和相互作用通常很难检测到。拟议的研究将使用称为协作杂交（CC）的新小鼠种群确定男性不育症的基本差异。 CC旨在促进与复杂性状相关的映射基因。在繁殖过程中，高达50％的初期线停止产生后代，并被宣布灭绝，而男性不育症是这种灭绝的主要机制。这种不育的雄性小鼠的大量种群可用于更好地了解雄性不育症的生物学和遗传学及其相关的生殖参数，例如精子计数和睾丸结构。该项目对于开发适用于CC人群的新方法也很有价值。