权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Gene-by-Environment Interactions, Social Stress, and Depression in Older Adults

老年人的基因与环境相互作用、社会压力和抑郁症

基本信息

批准号：
8566620
负责人：
Mark A Whisman
金额：
$ 7.63万
依托单位：
UNIVERSITY OF COLORADO
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-15 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8566620
关键词：
Area Candidate Disease Gene Characteristics Child Data Disease susceptibility Elderly Emotional Environment Etiology Friends Genes Genetic Genetic Crossing Over Genetic Predisposition to Disease Goals Health Individual Investigation Life Stress Link Measures Mental Depression Mental disorders Methodology Modeling Nature Participant Predisposition Preventive Intervention Public Health Publishing Relative (related person)Research Research Personnel Retirement Risk Role Sampling Scientific Advances and Accomplishments Severities Single Nucleotide Polymorphism Social Environment Social support Specificity Spouses Stress Surveys Susceptibility Gene Testing Theoretical model Twin Studies gene environment interaction geriatric depression improved interest novel population based prevent social social stress stressor therapy development

项目摘要

DESCRIPTION (provided by applicant): Depression is one of the most widespread and debilitating psychiatric disorders. Among older individuals, depression is the most frequent cause of emotional suffering, and the detrimental effects of late-life depression are well documented. One common theoretical model for understanding depression is the perspective that genetic characteristics interact with environmental influences in predicting the onset, severity, and course of depression. There has been considerable interest in evaluating such gene-by-environment interactions, including twin studies that have examined latent genetic influences and candidate gene studies that have evaluated the potential moderating role of specific genes. In the proposed research, we seek to build on prior gene-by-environment research through conducting a reanalysis of existing data from a large, population-based sample of older adults (i.e., the Health and Retirement Study) to provide a test of a novel gene-by-environment model for depression that integrates genetic and social perspectives. Specifically, the proposed research seeks to build on prior gene-by-environment research through (a) expanding the assessment of genetic influences by using a gene-environment-wide interaction study (GEWIS) approach, (b) focusing the assessment of environmental influences on a stressor that has been consistently associated with depression (i.e., social stress), (c) disaggregating the assessment of social stress to evaluate whether stress in certain relationships (e.g., one's relationship with one's spouse or partner) is more strongly associated with depression than is stress in other relationships (e.g., one's relationships with one's childre, relatives, and friends), and (d) evaluating both vulnerability and differential susceptibility gene by-environment models. There are no published GEWIS studies on depression, and so the proposed research will be an important scientific advance as it will be among the first studies to use this methodology in examining the genetic vulnerability to environmental influences on depression. Furthermore, there are few studies that have evaluated the differential susceptibility model with respect to depression, particularly among older individuals, and so the study will be among the first studies to compare vulnerability and differential susceptibility gene-by-environment models of depression in older adults. Finally, by examining social stress across several types of social relationships, the results from the proposed research will provide important advances in identifying particular social relationships for which stress is most strongly associated with depression that can be targeted in preventing and treating depression in at-risk older adults.

描述（由申请人提供）：抑郁症是最普遍和最衰弱的精神疾病之一。在老年人中，抑郁症是情绪痛苦的最常见原因，晚年抑郁症的有害影响有据可查。理解抑郁症的一个常见理论模型是遗传特征与环境影响相互作用的观点，预测抑郁症的发作，严重程度和病程。人们对评估这种基因与环境的相互作用非常感兴趣，包括研究潜在遗传影响的双胞胎研究和评估特定基因潜在调节作用的候选基因研究。在拟议的研究中，我们寻求通过重新分析来自大量基于人群的老年人样本的现有数据（即，健康和退休研究），以提供一个新的基因与环境模型的抑郁症，整合遗传和社会的观点测试。具体来说，拟议的研究旨在通过以下方式建立在先前的基因-环境研究的基础上：（a）通过使用基因-环境-全交互研究（GEWIS）方法扩大对遗传影响的评估，（B）将环境影响的评估集中在与抑郁症一致相关的压力源上（即，社会压力），（c）分解社会压力的评估以评估某些关系中的压力（例如，一个人与其配偶或伴侣的关系）比其他关系中的压力（例如，一个人与孩子、亲戚和朋友的关系），以及（d）评估脆弱性和差异易感性基因环境模型。目前还没有关于抑郁症的GEWIS研究发表，因此这项研究将是一项重要的科学进步，因为它将是第一批使用这种方法来研究遗传对抑郁症环境影响的脆弱性的研究之一。此外，很少有研究评估抑郁症的差异易感性模型，特别是在老年人中，因此该研究将是第一批比较老年人抑郁症的脆弱性和差异易感性基因-环境模型的研究。最后，通过检查几种类型的社会关系中的社会压力，拟议研究的结果将在确定压力最强烈的特定社会关系方面提供重要的进展。与抑郁症相关，可用于预防和治疗高危老年人的抑郁症。