Making and breaking the left-right axis: Laterality in development and disease

描述（由申请人提供）：这是一份申请，支持将于2013年6月15日至16日在墨西哥坎昆举行的题为“左右轴的形成和断裂：发育和疾病中的偏侧性”的会议，就在第72届发育生物学学会年会和第17届国际发育生物学大会之前。本次卫星研讨会的目的是将研究无脊椎动物和脊椎动物模型的研究人员聚集在一起，介绍关于左右不对称的发展和疾病相关性的最新结果。尽管这一领域最近有许多令人兴奋的发展，但自2001年胡安·马奇研究所在马德里主办了一个小型讲习班以来，一直没有举行过关于这一特定主题的会议。从那时起，关于偏侧性是如何在胚胎中建立和维持的，以及由异常的左右模式导致的常见疾病，如纤毛病、多囊肾病和肝病以及复杂的先天性心脏病，已经有了许多发现。在神经系统发育中侧边性的重要性及其对行为的影响方面也获得了新的见解。受邀的演讲者将首次团结起来

DESCRIPTION (provided by applicant): This is an application for support of a conference entitled "Making and breaking the left-right axis: Laterality in development and disease" to be held June 15-16, 2013 in Cancun, Mexico, just prior to the joint Society for Developmental Biology 72nd Annual Meeting and the 17th International Congress of Developmental Biology. The objective of this satellite symposium is to bring together researchers working on invertebrate and vertebrate models for an up-to-date presentation of the latest results on the development and disease relevance of left-right asymmetry. Although there have been many exciting recent developments in the field, a meeting on this specific subject has not been held since 2001, when a small workshop was sponsored by the Instituto Juan March in Madrid. Since then, numerous discoveries have been made on how sidedness is established and maintained in the embryo and the common disorders that can result from abnormal left-right patterning, such as ciliopathies, polycystic kidney and liver disease and complex congenital heart disease. New insights have also been obtained on the significance of laterality in the developing nervous system and its influence on behavior. The group of invited speakers will, for the first time, unite researchers working on left-right symmetry breaking in diverse developmental models and organ systems. The high degree of enthusiasm expressed by researchers who have already agreed to participate indicates the timeliness and level of interest for a symposium on this topic. We anticipate that this symposium will attract approximately 100 participants, with the size and format of the event encouraging maximal interaction among the attendees. The co-organizers will also inform the scientific community more broadly by serving as guest editors of a journal issue dedicated to the symposium topic on the development of L-R asymmetry.