Making and breaking the left-right axis: Laterality in development and disease

描述（由申请人提供）：这是一份申请，旨在支持将于2013年6月15日至16日在墨西哥坎昆举行的题为“制造和打破左右轴：发育和疾病中的偏侧性”的会议，就在发育生物学协会第72届年会和第17届发育生物学国际大会之前。这次卫星研讨会的目的是汇集研究无脊椎动物和脊椎动物模型的研究人员，介绍关于左右不对称的发展和疾病相关性的最新结果。虽然最近在这一领域取得了许多令人振奋的进展，但自2001年胡安·马奇研究所在马德里主办了一个小型讲习班以来，就没有举行过关于这一具体主题的会议。从那时起，关于胚胎中如何建立和维持侧性以及异常左右模式可能导致的常见疾病，如纤毛病，多囊肾和肝脏疾病以及复杂的先天性心脏病，已经有了许多发现。关于神经系统发育中偏侧化的意义及其对行为的影响也有了新的认识。受邀演讲者将首次联合起来 研究人员致力于在不同的发育模型和器官系统中打破左右对称。已经同意参加的研究人员表现出的高度热情表明，就这一专题举行一次专题讨论会是及时的，也是人们感兴趣的。 我们预计，本次研讨会将吸引约100名与会者，活动的规模和形式鼓励与会者之间的最大互动。共同组织者还将通过担任专门讨论L-R不对称发展专题的期刊的客座编辑，更广泛地向科学界提供信息。

DESCRIPTION (provided by applicant): This is an application for support of a conference entitled "Making and breaking the left-right axis: Laterality in development and disease" to be held June 15-16, 2013 in Cancun, Mexico, just prior to the joint Society for Developmental Biology 72nd Annual Meeting and the 17th International Congress of Developmental Biology. The objective of this satellite symposium is to bring together researchers working on invertebrate and vertebrate models for an up-to-date presentation of the latest results on the development and disease relevance of left-right asymmetry. Although there have been many exciting recent developments in the field, a meeting on this specific subject has not been held since 2001, when a small workshop was sponsored by the Instituto Juan March in Madrid. Since then, numerous discoveries have been made on how sidedness is established and maintained in the embryo and the common disorders that can result from abnormal left-right patterning, such as ciliopathies, polycystic kidney and liver disease and complex congenital heart disease. New insights have also been obtained on the significance of laterality in the developing nervous system and its influence on behavior. The group of invited speakers will, for the first time, unite researchers working on left-right symmetry breaking in diverse developmental models and organ systems. The high degree of enthusiasm expressed by researchers who have already agreed to participate indicates the timeliness and level of interest for a symposium on this topic. We anticipate that this symposium will attract approximately 100 participants, with the size and format of the event encouraging maximal interaction among the attendees. The co-organizers will also inform the scientific community more broadly by serving as guest editors of a journal issue dedicated to the symposium topic on the development of L-R asymmetry.