2013 Matrix Metalloproteinase Gordon Research Conference and Gordon Research Semi

描述(由申请者提供)：关于基质金属蛋白酶(MMPs)的戈登研究会议(GRC)是对癌症、转移性疾病、结缔组织疾病(如关节炎)以及多种炎症、肺、心血管和神经疾病具有特殊重要性的科学领域的首要会议。这次会议涵盖了与疾病相关的金属蛋白酶的全部基础和翻译研究，这些金属蛋白酶具有共同的催化和调节机制，即基质金属蛋白酶、ADAM(一种去整合素和金属蛋白酶)、ADAMTS(具有凝血酶反应蛋白基序的ADAM)和阿司匹林样蛋白酶及其抑制物。2013年MMP-GRC将于2013年5月19日至24日在意大利托斯卡纳巴尔加的Il Ciocco Tuscany度假村举行，并与Gordon-Kenan研究研讨会(2013年5月18日至19日)同时举行。2013年的MMPGRC和MMPGRS是住宅会议，这一传统一直导致前几届MMPGRC的成功。MMPGRC和MMPGRS提供了一个无与伦比的论坛，让受训者与现有的研究人员相互交融。会议的驻地形式促进了与会科学家之间的密切互动、合作和社区意识，他们来自世界各地的学术界、制药行业和政府部门。这两个机构的使命是通过自由交流思想推动科学创新，促进合作，培养该领域的下一代科学家，所有这些都以促进人类健康为最终目标。2013年的基质金属蛋白酶-GRC和基质金属蛋白酶-GRS以癌症为主要疾病焦点，并创新的主题强调金属蛋白酶作为分子网络和疾病途径的组成部分。会议包括9个环节，强调介绍未公布的数据，并提供充足的讨论时间，并有额外的自由时间用于非正式互动。会议由经验丰富的科学家主持，他们因其专业知识、多样性和在该领域的地位而从金属蛋白酶社区中挑选出来。国际发言者名单实现了性别平衡和具有代表性的族裔/种族多样性，其中包括许多职业生涯早期的调查员。社区更新的重点是确保大多数受邀演讲者以前从未在MP-GRC上发言。会议计划对基础科学和翻译科学给予同等重视。每一次基础会议都与了解癌症途径高度相关，另外还有一项重点是细胞外基质，它不仅与癌症间质有关，而且与结缔组织疾病有关。参与者的选择依据是他们对该领域的兴趣和目前与该领域有关的活动，以及他们所提交的正在进行的工作的摘要。三分之一 会议平台的发言将从摘要中挑选出来，并有两个海报会议，以便有充足的时间进行讨论。我们期待这次会议能够激发和鼓舞人们，并为近期的前沿研究设定新的目标和方向。

DESCRIPTION (provided by applicant): The Gordon Research Conference (GRC) on Matrix Metalloproteinases (MMPs) (the MMP-GRC) is the premier meeting in a scientific field of exceptional importance for cancer, metastatic disease, connective tissue disorders such as arthritis, and numerous inflammatory, lung, cardiovascular and neurological conditions. The conference spans the full spectrum of fundamental and translational research on disease-relevant metalloproteinases that share catalytic and regulatory mechanisms, i.e., MMP, ADAM (a disintegrin and metalloproteinase), ADAMTS (ADAM with thrombospondin motifs) and astacin-like proteases, and their inhibitors. The 2013 MMP-GRC will be held at the Il Ciocco Tuscany Resort, Barga, Tuscany, Italy, from May 19-24, 2013 and is conjoined with a Gordon-Kenan Research Seminar (MMP-GRS) (May 18-19, 2013). The 2013 MMP-GRC and MMP-GRS are residential conferences, a tradition that has consistently led to the success of previous MMP-GRCs. The MMP-GRC and MMP-GRS provide an unparalleled forum for intermingling of trainees with established investigators. The residential format of the conference promotes close interactions, collaborations, and a sense of community in the participating scientists, who are drawn from academia, pharmaceutical industry and government sectors from around the world. The mission of the MMP- GRC and MMP-GRS is to advance scientific innovation with free exchange of ideas, to facilitate collaborations, and to nurture the next generation of scientists i the field, all with the ultimate goal of promoting human health. The 2013 MMP-GRC and MMP-GRS have a major disease focus on cancer, and an innovative thematic emphasis on metalloproteinases as integral components of molecular networks and disease pathways. The conference comprises 9 sessions that emphasize presentation of unpublished data and offer abundant time for discussion, with additional free time available for informal interactions. Sessions are chaired by experienced scientists, who are drawn from within the metalloproteinase community for their expertise, diversity and stature in the field. The international slate of speakers achieves a gender balance and representative cross-section of ethnic/racial diversity and includes numerous early-career investigators. Community renewal is emphasized by ensuring that the majority of invited speakers have not spoken before at a MMP-GRC. The conference program gives equal emphasis to fundamental and translational science. Each fundamental session is highly relevant to understanding cancer pathways, and there is an additional strong emphasis on extracellular matrix, which is relevant not only to cancer stroma, but also to connective tissue disease. Participants are selected based on their interest in and current activities relevant to the field, and on submitted abstracts of their ongoing work. A third of the conference platform presentations will be selected from the abstracts with two poster sessions allowing abundant time for discussion. We expect the conference to stimulate and inspire, and to set new goals and directions for cutting-edge research for the near future.