2013 Matrix Metalloproteinase Gordon Research Conference and Gordon Research Semi

描述（由申请人提供）：关于基质金属蛋白酶（MMPs）的戈登研究会议（GRC）（MMP-GRC）是对癌症、转移性疾病、结缔组织疾病（如关节炎）和许多炎症、肺、心血管和神经系统疾病具有特殊重要性的科学领域的首要会议。会议涵盖了疾病相关金属蛋白酶的基础和转化研究的全方位，这些金属蛋白酶共享催化和调节机制，即，MMP、ADAM（一种去整合素和金属蛋白酶）、ADAMTS（具有血小板反应蛋白基序的ADAM）和虾红素样蛋白酶，以及它们的抑制剂。2013年MMP-GRC将于2013年5月19日至24日在意大利托斯卡纳巴尔加的Il Ciocco托斯卡纳度假村举行，并与戈登-凯南研究研讨会（MMP-GRS）（2013年5月18日至19日）联合举行。2013年MMP-GRC和MMP-GRS是住宅会议，这一传统一直导致以前的MMP-GRC取得成功。MMP-GRC和MMP-GRS提供了一个无与伦比的论坛，让学员与既定的调查人员相互交流。会议的住宅形式促进了参与科学家的密切互动，合作和社区意识，他们来自世界各地的学术界，制药业和政府部门。MMP-GRC和MMP-GRS的使命是通过自由交流思想来推进科学创新，促进合作，并培养该领域的下一代科学家，所有这些都以促进人类健康为最终目标。 2013年MMP-GRC和MMP-GRS的主要疾病重点是癌症，创新的主题重点是金属蛋白酶作为分子网络和疾病途径的组成部分。会议包括9场会议，强调未发表数据的介绍，并提供充足的时间进行讨论，额外的自由时间可用于非正式互动。会议由经验丰富的科学家主持，他们来自金属蛋白酶界，以其专业知识，多样性和在该领域的地位。发言者的国际名单实现了性别平衡和民族/种族多样性的代表性截面，包括许多早期职业调查员。通过确保大多数受邀演讲者之前没有在MMP-GRC上发言来强调社区更新。会议计划同等重视基础科学和转化科学。每一个基本会议是高度相关的理解癌症的途径，并有一个额外的强烈强调细胞外基质，这不仅是相关的癌症间质，但也结缔组织疾病。参与者的选择是基于他们对该领域的兴趣和目前的相关活动，以及他们正在进行的工作的摘要。第三 将从摘要中选出会议平台的专题介绍，并安排两次海报会议，以便有充足的时间进行讨论。我们希望这次会议能够激励和启发，并为不久的将来的前沿研究设定新的目标和方向。

DESCRIPTION (provided by applicant): The Gordon Research Conference (GRC) on Matrix Metalloproteinases (MMPs) (the MMP-GRC) is the premier meeting in a scientific field of exceptional importance for cancer, metastatic disease, connective tissue disorders such as arthritis, and numerous inflammatory, lung, cardiovascular and neurological conditions. The conference spans the full spectrum of fundamental and translational research on disease-relevant metalloproteinases that share catalytic and regulatory mechanisms, i.e., MMP, ADAM (a disintegrin and metalloproteinase), ADAMTS (ADAM with thrombospondin motifs) and astacin-like proteases, and their inhibitors. The 2013 MMP-GRC will be held at the Il Ciocco Tuscany Resort, Barga, Tuscany, Italy, from May 19-24, 2013 and is conjoined with a Gordon-Kenan Research Seminar (MMP-GRS) (May 18-19, 2013). The 2013 MMP-GRC and MMP-GRS are residential conferences, a tradition that has consistently led to the success of previous MMP-GRCs. The MMP-GRC and MMP-GRS provide an unparalleled forum for intermingling of trainees with established investigators. The residential format of the conference promotes close interactions, collaborations, and a sense of community in the participating scientists, who are drawn from academia, pharmaceutical industry and government sectors from around the world. The mission of the MMP- GRC and MMP-GRS is to advance scientific innovation with free exchange of ideas, to facilitate collaborations, and to nurture the next generation of scientists i the field, all with the ultimate goal of promoting human health. The 2013 MMP-GRC and MMP-GRS have a major disease focus on cancer, and an innovative thematic emphasis on metalloproteinases as integral components of molecular networks and disease pathways. The conference comprises 9 sessions that emphasize presentation of unpublished data and offer abundant time for discussion, with additional free time available for informal interactions. Sessions are chaired by experienced scientists, who are drawn from within the metalloproteinase community for their expertise, diversity and stature in the field. The international slate of speakers achieves a gender balance and representative cross-section of ethnic/racial diversity and includes numerous early-career investigators. Community renewal is emphasized by ensuring that the majority of invited speakers have not spoken before at a MMP-GRC. The conference program gives equal emphasis to fundamental and translational science. Each fundamental session is highly relevant to understanding cancer pathways, and there is an additional strong emphasis on extracellular matrix, which is relevant not only to cancer stroma, but also to connective tissue disease. Participants are selected based on their interest in and current activities relevant to the field, and on submitted abstracts of their ongoing work. A third of the conference platform presentations will be selected from the abstracts with two poster sessions allowing abundant time for discussion. We expect the conference to stimulate and inspire, and to set new goals and directions for cutting-edge research for the near future.