American Society for Matrix Biology Biennial Meeting 2014

描述(由申请者提供)：申请资助将于2014年10月12-15日在俄亥俄州克利夫兰举行的美国基质生物学学会(ASMB)第七届双年度会议(ASMB 2014)。ASMB是一个全国性的协会，其使命是促进细胞外基质(ECM)、细胞-ECM相互作用以及基于ECM的疗法和设备的基础、翻译和临床研究，并支持基质生物学研究社区的专业发展。它的两年一次的会议提供了一个深入的论坛，整合了关于遗传学、分子生物学、生物化学、病理生物学和ECM所有方面的翻译相关性的新信息。此外，本次会议通过强调细胞与细胞外基质的相互作用和细胞外基质驱动的信号传递，提供了细胞生物学和细胞内信号传递的连续体。ASMB会议的这种包罗万象的、沉浸在矩阵中的方面在大型社会会议中是缺乏的，不同于ECM社区可用的单分子或以过程为重点的会议，包括Gordon、Keystone和FASEB会议。细胞外基质和基质受体基因突变导致遗传性结缔组织疾病、骨骼发育不良、肌肉营养不良和水疱性皮肤病，细胞外基质调节失调普遍是影响所有器官系统的获得性疾病的主要因素，无论是急性还是慢性疾病。细胞外基质尤其与皮肤和肌肉骨骼系统有关，在这些系统中，细胞外基质是骨、软骨和肌腱的主要组成部分。在获得性条件中，骨关节炎、骨质疏松、动脉瘤、癌症和转移的病理涉及ECM的破坏，所有的纤维化条件和异常的伤口愈合都以过度或失调的ECM为特征。ASMB2014具有相当大的翻译相关性，特别是对组织修复和工程，并提供了推进这些领域的基础科学基础。ASMB会议汇集了来自不同研究领域和医学专业的科学家、临床科学家、博士后实习生和研究生，讨论细胞外基质生物学的最新进展及其与人类疾病的相关性。这一激动人心的为期3天的计划包括杰克·迪克森博士关于蛋白质磷酸化的主旨演讲，五次全体会议和18次同时举行的主题会议，这些主题为学员提供了许多简短演讲的机会。除了促进基质生物学领域的发展外，ASMB2014还表明了为在职和女性基质生物学家提供机会的承诺，并有具体的指导部分。ASMB2014的这些目标和活动与美国国立卫生研究院的使命和R13机制的意图完全一致。

DESCRIPTION (provided by applicant): Funding is requested in partial support of the 7th Biennial Conference of the American Society for Matrix Biology (ASMB), which is to be held from Oct. 12-15, 2014, in Cleveland, OH (ASMB2014). ASMB is a national society whose mission is to promote basic, translational, and clinical research on the extracellular matrix (ECM), cell-ECM interactions, and ECM-based therapies and devices, and to support professional development of the matrix biology research community. Its biennial conference provides an in-depth forum integrating new information on the genetics, molecular biology, biochemistry, pathobiology, and translational relevance of all aspects of ECM. Additionally, this conference provides a continuum with cell biology and intracellular signaling via an emphasis on cell-ECM interactions and ECM-driven signaling. This all-encompassing, matrix-immersion aspect of the ASMB conference is lacking in large society conferences and is distinct from the single molecule- or process-focused conferences available to the ECM community, including Gordon, Keystone and FASEB conferences. ECM and matrix receptor gene mutations lead to inherited connective tissue disorders, skeletal dysplasias, muscular dystrophies and blistering skin diseases, and ECM dysregulation is universally a major factor in acquired diseases, both acute and chronic, affecting all organ systems. ECM is especially relevant to skin and the musculoskeletal system, where it is a primary component of bone, cartilage and tendons. Among acquired conditions, the pathology of osteoarthritis, osteoporosis, aneurysms, cancer and metastasis involves ECM destruction, and all fibrotic conditions and aberrant wound healing feature an excess or dysregulated ECM. ASMB2014 has considerable translational relevance, especially to tissue repair and engineering, and provides the basic science foundation upon which to advance these fields. The ASMB Conference brings together scientists, clinician-scientists, post-doctoral trainees, and graduate students from diverse research fields and medical specialties to discuss the most recent advances in ECM biology and their relevance to human disease. The exciting 3-day program comprises a keynote address on protein phosphorylation by Dr. Jack Dixon, five plenary sessions and 18 concurrent sessions on focused topics that provide many opportunities for short talks by trainees. In addition to advancement of the matrix biology field, ASMB2014 demonstrates a commitment to providing opportunities for in-training and women matrix biologists and has specific mentoring components. These goals and activities of ASMB2014 are fully consistent with the mission of NIH and the intent of the R13 mechanism.