Creation of the Einstein Aging Study Data Warehouse

描述(由申请人提供)：爱因斯坦老龄化研究(EAS)项目(NIH NIA：P01 AG03949)是对纽约布朗克斯区不同社区样本中自然衰老历史和痴呆症发病的纵向研究。我们建议将EAS数据集存档在国家老龄化计算机化数据档案馆(NACDA)，以使这一丰富而独特的数据集可供公众使用。这将有助于对老化过程的调查，这超出了我们资助的研究的范围。20多年来，EAS系统地招募和跟踪了一个以社区为基础的多种族队列(n=2014，年龄=70)。通过在基线和此后每年进行广泛的评估，对东亚行动参与者进行了全面评估，平均跟踪时间为4.0年(范围为1-17年)。来自EAS的数据表明，老年人的认知、运动和死亡结果之间存在密切联系，并已被用于确定导致这些结果的新的生物和心理社会风险因素。EAS队列广泛代表了布朗克斯县的老年人口，布朗克斯县是美国人口结构最多样化的县之一。自2003年以来，EAS一直遵守NIH的数据共享任务。许多数据共享请求都是NIH多项合作研究的一部分。然而，到目前为止，这些综合分析的分析重点仅限于与阿尔茨海默病和认知能力下降有关的EAS变量的谨慎子集，结果是大量的EAS数据资源仍未得到充分利用。拟议的数据存档项目将使我们能够以两种基本方式建立在现有数据库的基础上：(1)捕获和保存1993-2003年(在国家卫生研究院提出强制性数据共享政策之日(2003年10月1日)之前)在我们的队列中评估的各种变量。这包括协调以前未存档的数据与当前的EAS数据库；以及(2)扩展数据库，以包括由试点项目、基金会拨款和附属的NIH R01资助的行为、生物和心理社会措施的主机，这些措施不是主要EAS计划项目的一部分。创建和记录新的摘要措施和标准格式将是这一进程的一部分。这项提议的中心目标是存档和保存扩大的东亚气候数据库，以促进有效和具有成本效益地使用我们长期和特点良好的队列中的大量科学资源。拟议的与NACDA的合作将确保我们向国内和国际老龄研究界广泛传播高质量数据的能力。

DESCRIPTION (provided by applicant): The Einstein Aging Study (EAS) program project (NIH NIA: P01 AG03949) is a longitudinal study of the natural history of aging and the onset of dementia in a diverse community-based sample in Bronx, New York. We propose to archive the EAS dataset at the National Archive of Computerized Data on Aging (NACDA), in order to make this rich and unique data set available for public use. This will facilitate investigations into th aging process that are beyond the scope of our funded studies. The EAS has systematically recruited and followed a community-based, multi-racial cohort (n=2014, ages >=70) for more than 20 years. EAS participants have been comprehensively characterized via extensive evaluations at baseline and annually thereafter, with an average follow-up time of 4.0 years (range, 1-17 years). Data from the EAS have demonstrated strong links among cognitive, locomotor, and mortality outcomes in the elderly and have been used to identify novel biological and psychosocial risk factors that contribute to these outcomes. The EAS cohort is broadly representative of the elderly population of the Bronx, one of the most demographically diverse counties in the United States. Since 2003, the EAS has complied with the NIH data sharing mandate. Many of the data sharing requests has been part of multiple NIH collaborative studies. To date, however, the analytic focus of these pooled analyses has been limited to the discreet subset of EAS variables related to Alzheimer's disease and cognitive decline, with the result that much of the extensive EAS data resource remains underexploited. The proposed Data Archiving project will permit us to build on the extant database in two essential ways: (1) to capture and preserve the wide range of variables assessed in our cohort during the years 1993-2003 (prior to the date of the Mandatory Data Sharing Policy put forth by the NIH (October 1, 2003)). This includes harmonizing previously un-archived data with the current EAS database; and (2) to expand the database to include the host of behavioral, biological and psychosocial measures, not part of the primary EAS program project, that have been funded from pilot projects, foundation grants, and affiliated NIH R01s. Creating and documenting new summary measures and standard formats will be part of the process. The central aims of this proposal are to archive and preserve an expanded EAS data base in order to facilitate efficient and cost effective use of the extensive scientific resources from our long-standing and well-characterized cohort. The proposed collaboration with NACDA will ensure our capacity for wide-spread dissemination of high quality data to the national and international aging research communities.