Creation of the Einstein Aging Study Data Warehouse

创建爱因斯坦衰老研究数据仓库

• 批准号: 8572829
• 负责人: mindy katz
• 金额: $ 8.35万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-15 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8572829
• 关键词: Age; Age of Onset; Aging; Aging-Related Process; Agreement; Alzheimer' s Disease; Archives; Behavioral; Biological; Biological Assay; Blood; Clinic; Cognitive; Cohort Analysis; Cohort Studies; Collaborations; Communities; Comorbidity; County; Data; Data Quality; Data Set; Databases; Dementia; Elderly; Emotional; Enrollment; Ensure; Evaluation; Family; Foundations; Funding; Gait; Grant; Health; Health behavior; Impaired cognition; Individual; Information Systems; International; Investigation; Link; Longitudinal Studies; Measures; Medical; Mental Health; Meta-Analysis; Methods; Moods; Motor; Natural History; Neurologic Examination; New York; Online Systems; Outcome; Participant; Personal Satisfaction; Persons; Pharmaceutical Preparations; Physical Function; Pilot Projects; Policies; Population; Process; Quality of life; Recording of previous events; Recruitment Activity; Research; Research Personnel; Resources; Retrieval; Risk Factors; Sampling; Selection Bias; Sensory; Stress; Testing; Time; United States; United States National Institutes of Health; Work; base; cognitive function; cohort; computerized; cost effective; data format; data management; data sharing; demographics; follow-up; genome wide association study; indexing; medical examination; mortality; neuroimaging; neuropathology; neuropsychological; novel; parent grant; programs; psychosocial; racial and ethnic; social; standard measure

DESCRIPTION (provided by applicant): The Einstein Aging Study (EAS) program project (NIH NIA: P01 AG03949) is a longitudinal study of the natural history of aging and the onset of dementia in a diverse community-based sample in Bronx, New York. We propose to archive the EAS dataset at the National Archive of Computerized Data on Aging (NACDA), in order to make this rich and unique data set available for public use. This will facilitate investigations into th aging process that are beyond the scope of our funded studies. The EAS has systematically recruited and followed a community-based, multi-racial cohort (n=2014, ages >=70) for more than 20 years. EAS participants have been comprehensively characterized via extensive evaluations at baseline and annually thereafter, with an average follow-up time of 4.0 years (range, 1-17 years). Data from the EAS have demonstrated strong links among cognitive, locomotor, and mortality outcomes in the elderly and have been used to identify novel biological and psychosocial risk factors that contribute to these outcomes. The EAS cohort is broadly representative of the elderly population of the Bronx, one of the most demographically diverse counties in the United States. Since 2003, the EAS has complied with the NIH data sharing mandate. Many of the data sharing requests has been part of multiple NIH collaborative studies. To date, however, the analytic focus of these pooled analyses has been limited to the discreet subset of EAS variables related to Alzheimer's disease and cognitive decline, with the result that much of the extensive EAS data resource remains underexploited. The proposed Data Archiving project will permit us to build on the extant database in two essential ways: (1) to capture and preserve the wide range of variables assessed in our cohort during the years 1993-2003 (prior to the date of the Mandatory Data Sharing Policy put forth by the NIH (October 1, 2003)). This includes harmonizing previously un-archived data with the current EAS database; and (2) to expand the database to include the host of behavioral, biological and psychosocial measures, not part of the primary EAS program project, that have been funded from pilot projects, foundation grants, and affiliated NIH R01s. Creating and documenting new summary measures and standard formats will be part of the process. The central aims of this proposal are to archive and preserve an expanded EAS data base in order to facilitate efficient and cost effective use of the extensive scientific resources from our long-standing and well-characterized cohort. The proposed collaboration with NACDA will ensure our capacity for wide-spread dissemination of high quality data to the national and international aging research communities.

描述（由申请人提供）：爱因斯坦衰老研究 (EAS) 计划项目（NIH NIA：P01 AG03949）是一项针对纽约布朗克斯多元化社区样本中衰老自然史和痴呆症发作的纵向研究。我们建议将 EAS 数据集存档于国家老龄化计算机化数据档案馆 (NACDA)，以便使这一丰富而独特的数据集可供公众使用。这将有助于对超出我们资助研究范围的衰老过程进行调查。 20 多年来，EAS 系统地招募并跟踪了一个基于社区的多种族队列（n=2014，年龄 >=70）。通过基线和之后每年的广泛评估，对 EAS 参与者进行了全面的表征，平均随访时间为 4.0 年（范围为 1-17 年）。 EAS 的数据表明，老年人的认知、运动和死亡率结果之间存在密切联系，并已被用来识别导致这些结果的新的生物和心理社会风险因素。 EAS 群体广泛代表了布朗克斯区的老年人口，布朗克斯区是美国人口最多元化的县之一。自 2003 年以来，EAS 一直遵守 NIH 的数据共享授权。许多数据共享请求是 NIH 多项合作研究的一部分。然而，迄今为止，这些汇总分析的分析重点仅限于与阿尔茨海默病和认知能力下降相关的 EAS 变量的谨慎子集，结果是大部分广泛的 EAS 数据资源仍未得到充分利用。拟议的数据归档项目将使我们能够以两种基本方式在现有数据库的基础上进行构建：(1) 捕获并保存 1993-2003 年期间（在 NIH 提出的强制性数据共享政策之前（2003 年 10 月 1 日））在我们队列中评估的广泛变量。这包括将以前未归档的数据与当前的 EAS 数据库进行协调； (2) 扩展数据库，纳入大量行为、生物和社会心理测量，这些测量不是主要 EAS 计划项目的一部分，而是由试点项目、基金会拨款和附属 NIH R01 资助。创建和记录新的汇总措施和标准格式将是该过程的一部分。该提案的核心目标是归档和保存扩展的 EAS 数据库，以促进高效且具有成本效益地利用我们长期存在且特征鲜明的群体中的广泛科学资源。拟议与 NACDA 的合作将确保我们有能力向国内和国际老龄化研究界广泛传播高质量数据。