Effectiveness of the Influenza Vaccine in the Aging Population

流感疫苗对老年人群的有效性

• 批准号: 8417869
• 负责人: HELEN Keipp TALBOT
• 金额: $ 31.98万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8417869
• 关键词: Activities of Daily Living; Acute; Address; Adult; Age; Age-Years; Aging; Applications Grants; Caring; Case-Control Studies; Cessation of life; Clinical; Comorbidity; Data; Data Collection; Data Set; Databases; Diagnosis; Drug Formulations; Effectiveness; Elderly; Event; Hospitalization; Immune; Immune response; Immune system; Individual; Influenza; Influenza vaccination; Laboratories; Licensing; Link; Lung; Measurement; Measures; Medical; Medical Records; Methodology; Methods; Molecular; NIH Program Announcements; Observational Study; Outcome; Participant; Patients; Persons; Population; Predisposition; Prevention; Proteins; Questionnaires; Research; Research Design; Research Personnel; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; Risk; Sampling; Seasons; Subunit Vaccines; Testing; United States; Vaccinated; Vaccination; Vaccines; Viral Vaccines; Virion; Virus; Work; administrative database; age group; aging population; case control; design; frailty; indexing; influenza virus vaccine; instrument; manufacturing process; mortality; prevent; prospective; public health relevance; respiratory; respiratory virus; response; senescence; vaccine effectiveness

DESCRIPTION (provided by investigator): This study application is a secondary analysis of an existing database in response to the Program Announcement, PA-09-265: Secondary Analyses of Existing Data Sets and Stored BioSpecimens to Address Clinical Aging Research Questions (R01) to determine influenza vaccine effectiveness in older adults. Recent work has shown that more is needed to be known about influenza vaccine effectiveness in older adults and the methodology used to determine that vaccine effectiveness. This database is an accumulation of three studies that prospectively tested older adults for influenza. This data will be used to determine if the current methodology of test-negative controls will actually control for the bias of frailty, will determine vaccine effectiveness in the very old, and will explore if vaccne manufacturing process impacts effectiveness.

描述（由研究者提供）：本研究申请是根据项目公告PA-09-265：对现有数据集和储存生物标本进行二次分析以解决临床衰老研究问题（R01），对现有数据库进行二次分析，以确定流感疫苗对老年人的有效性。最近的工作表明，需要更多地了解流感疫苗对老年人的有效性以及用于确定疫苗有效性的方法。该数据库是对老年人流感前瞻性测试的三项研究的积累。这些数据将用于确定目前检测阴性对照的方法是否能够实际控制