Hospital Admissions & Emergency Room Visits in Adults Associated with Influenza C

医院入院

• 批准号: 9252833
• 负责人: HELEN Keipp TALBOT
• 金额: $ 1.75万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-02-15 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9252833
• 关键词: 15 year old; 2 year old; Accident and Emergency department; Acute; Acute respiratory infection; Admission activity; Adult; Age-Years; Ambulatory Care Facilities; Antibodies; Antigens; Caring; Case Study; Centers for Disease Control and Prevention (U.S.); Cessation of life; Child; Childhood; Clinic; Clinical; Clinical Data; Clinics and Hospitals; Common Cold; County; Data; Data Collection; Databases; Detection; Diagnosis; Diagnostic; Diagnostic Procedure; Disease; Elderly; Emergency department visit; Enrollment; Epidemiology; Etiology; Health; Health Care Visit; Healthcare; Hospitalization; Hospitals; Human; Human Metapneumovirus; Immune response; Immunocompromised Host; Infection; Influenza; Influenza A virus; Influenza B Virus; Influenza C Virus; Influenza vaccination; Japan; Life; Lower respiratory tract structure; Lung diseases; Medical; Modality; Morbidity - disease rate; Nigerian; Nose; Outpatients; Patients; Performance; Persons; Pharyngeal structure; Pneumonia; Polymerase Chain Reaction; Population; Positioning Attribute; Prevention; Prevention strategy; Questionnaires; Recurrence; Research; Research Design; Respiratory Signs and Symptoms; Respiratory Tract Diseases; Respiratory syncytial virus; Role; Sampling; Seasons; Serum; Signs and Symptoms; Specimen; Surveillance Program; Swab; Symptoms; Tennessee; Testing; Time; Vaccination; Viral; Virus; aged; base; burden of illness; cost effective; disorder prevention; experience; high risk; hospital admission rate; influenza virus vaccine; instrument; mortality; pandemic disease; pathogen; population based; prevent; programs; prospective; repository; respiratory; respiratory virus; treatment strategy; vaccine effectiveness

 DESCRIPTION (provided by applicant): Despite advances in diagnostic techniques, only 39-75% of episodes of respiratory illness in well-designed studies have an etiology identified. The introduction of polymerase chain reaction (PCR) has helped identified viral pathogens that were previously unidentified due to the poor performance of rapid antigen and culture diagnostics in older adults with influenza and respiratory syncytial virus being two of the most common viral etiologies. Unfortunately, without known etiologies, treatment and prevention strategies are missing. Hence more research is needed to identify pathogens associated with influenza-like illness and pneumonia. One potential pathogen is Influenza C. Influenza C originally called, the "1233 aberrant strain" was discovered in March 1947 during routine surveillance for influenza. One influenza C challenge study done in young healthy adults, described the resulting illness to be similar to the common cold, but data is unavailable who are older and sick. Due to lack of comprehensive studies in influenza C, there is not a good description of the clinical picture of influenza C in adults, nor have any population based rates been calculated. If influenza C causes a significant number of medically attended illness including hospitalizations inclusion of influenza C in the adult vaccination program may prevent morbidity and mortality. Information on adults with respiratory symptoms during the past six influenza seasons has been prospectively collected to determine rates of hospital admissions and to perform yearly case-positive, control-negative influenza vaccine effectiveness studies. The surveillance began in November of 2006 and was completed May 2012. Recruitment began yearly in November in ended in April with the exception of the pandemic where surveillance was continuous from November 2008 through May 2010. Patients were approached if they presented with a respiratory illness and for each participating subject, both a nasal and a throat swab sample were obtained for RT- PCR. Patient questionnaires and chart review captured CDC-defined high risk conditions, symptoms, and vaccinations. Using this data we will be able to accomplish the following aims. Specific Aims: 1. Test specimens for influenza C from a population-based sample of adults =50 years of age with health care visits for acute respiratory illness prospectively enrolled over 6 years. 2. Define the clinical and demographic features of illness associated with influenza C compared with influenza A and B and other respiratory viruses 3. Estimate rates of hospitalizations associated with influenza C among adults =50 years of age.

 描述(申请人提供)：尽管诊断技术取得了进步，但在精心设计的研究中，只有39%-75%的呼吸系统疾病的发作被确定了病因。在流感和呼吸道合胞病毒是两种最常见的病毒病原体的老年人中，由于快速抗原和培养诊断的表现不佳，聚合酶链式反应(PCR)的引入有助于识别以前未被识别的病毒病原体。不幸的是，在没有已知病因的情况下，治疗和预防策略缺失。因此，需要更多的研究来确定与流感样疾病和肺炎有关的病原体。一种潜在的病原体是C型流感。C型流感最初被称为“1233变异株”，是在1947年3月对流感进行常规监测时发现的。一项在年轻健康成年人中进行的C型流感挑战研究描述了导致的疾病类似于普通感冒，但无法获得年龄较大和生病的数据。由于缺乏对C型流感的全面研究，没有很好地描述成人C型流感的临床情况，也没有计算任何基于人群的发病率。如果C型流感导致大量的医疗护理疾病，包括住院，将C型流感纳入成人疫苗接种计划可能会预防发病率和死亡率。前瞻性地收集了过去六个流感季节中出现呼吸道症状的成年人的信息，以确定入院率，并进行每年病例阳性和对照阴性的流感疫苗有效性研究。监视工作于2006年11月开始，2012年5月完成。招募工作每年从11月开始，4月结束，大流行除外，从2008年11月到2010年5月一直在进行监测。如果患者有呼吸道疾病，就会接触他们，对于每个参与的受试者，都会同时采集鼻拭子和喉咙拭子样本进行RT-PCR。患者问卷和图表回顾捕获了疾控中心定义的高危条件、症状和疫苗接种。利用这些数据，我们将能够实现以下目标。具体目标：1.以人群为基础的成人样本中的C型流感检测样本=50岁，预期因急性呼吸道疾病就诊超过6年。2. 确定与甲型和乙型流感及其他呼吸道病毒相关疾病的临床和人口学特征3.估计成人中与丙型流感有关的住院率=50岁。