Home Objective Mobility Exam (HOME) for Balance and Gait Disorders in Parkinson's

描述（由申请人提供）：尽管平衡和步态障碍是老年人最常见和最具破坏性的慢性医学问题之一，尤其是患有慢性神经系统疾病的老年人，但临床医生或临床研究人员并不经常、准确或灵敏地测量平衡和步态。我们的长期目标是开发和商业化一个独特的系统，称为家庭客观移动检查（HOME），让患者在家里测量自己的平衡和步态。如果医生和物理治疗师能够获得频繁，准确，自我管理的平衡和步态特征的测量，那么他们将能够更早地预测跌倒风险和移动性的变化。这也将使他们能够迅速提高 采取干预措施，以预防行动残疾。本申请的目的是开发一种新方法，使患者能够通过快速、简单且非常易于使用的系统量化自己的站立平衡、步态和转弯。具体目标是：目标一。开发一个新版本的欧宝运动监测家庭使用。该目标的目的是将Opal传感器从基于计算机的临床医生/研究人员控制的系统转变为非专业/患者控制的运动监测系统。Aim II.确定帕金森病患者在家中测试自己的平衡和步态的可行性，有效性和可靠性。我们假设，平衡和步态，患者在自己家里测量，将是有效和可靠的研究助理和临床量表管理的措施相比，并显示出很好的重测信度。我们将首先开发HOME 对于帕金森病患者，因为他们比任何其他神经系统疾病有更多的福尔斯，但我们相信，这种工具将是有用的患者任何形式的移动残疾，如多发性硬化症，中风，头部损伤，发育障碍，多感觉缺陷，体弱老人等。我们的第二阶段应用将测试HOME的能力，与常规护理相比，在药物治疗或物理治疗改变后，它能更快地检测到平衡和步态的变化，为FDA的批准和广泛的销售做准备。

DESCRIPTION (provided by applicant): Although balance and gait disorders are one of the most common and devastating chronic medical problems of older people, especially those with chronic neurological diseases, clinicians or clinical researchers do not measure balance and gait frequently, accurately, or sensitively. Our long-term goal is to develop and commercialize a unique system called the Home Objective Mobility Exam (HOME) to allow patients to measure their own balance and gait at home. If physicians and physical therapists could obtain frequent, accurate, self-administered measures of balance and gait characteristics, then they will be able to earlier predict fall risk and changes in mobility. This will also enable them to quickly improve interventions in order to prevent mobility disability. The objective of this application is to deveop a novel method to allow patients to quantify their own standing balance, gait and turning with a quick, simple, and extremely easy to use system. The specifc aims are: Aim I. To develop a new version of the Opal movement monitor for home use. The objective of this aim is to transform the Opal sensors from a computer-based clinician/researcher-controlled system to a nonprofessional/patient-controlled system of movement monitoring. Aim II. To determine the feasibility, validity and reliability of having people with Parkinson's disease test their own balance and gait at home. We hypothesize that balance and gait, measured by patients in their homes, will be valid and reliable compared with measures administered by research assistants and with clinical scales and show very good test-retest reliability. We will initially develop HOME for patients with Parkinson's disease because they have more falls than any other neurological disorder, but we are confident that this tool will be useful for patients any form of mobility disability, such as multiple sclerosis, stroke, head injury, developmental disorders, multisensory deficits, frail elderly, etc. Based on results of this proposal, our Phase II application will thentest the ability of the HOME to more quickly detect changes in balance and gait following a change in medication or physical therapy, compared to usual care, in preparation for FDA approval and widespread marketing.