Home Objective Mobility Exam (HOME) for Balance and Gait Disorders in Parkinson's

描述(申请人提供)：虽然平衡和步态障碍是老年人，特别是患有慢性神经系统疾病的人最常见和最具破坏性的慢性医学问题之一，但临床医生或临床研究人员并不经常、准确或敏感地测量平衡和步态。我们的长期目标是开发一种独特的系统并将其商业化，该系统名为Home客观移动性检查(HOME)，允许患者在家中测量自己的平衡和步态。如果医生和理疗师能够获得频繁、准确、自我管理的平衡和步态特征测量，那么他们就能够更早地预测跌倒的风险和活动能力的变化。这也将使他们能够迅速提高 干预措施，以预防行动不便。这项应用的目的是开发一种新的方法，使患者能够用一个快速、简单和极易使用的系统来量化他们自己的站立平衡、步态和转身。具体目标是：目标一、开发家用新型蛋白石运动监测器。这一目标的目的是将Opal传感器从基于计算机的临床医生/研究人员控制的系统转变为非专业/患者控制的运动监测系统。目的II.确定帕金森病患者在家中测试自身平衡和步态的可行性、效度和可靠性。我们假设，由患者在家中测量的平衡和步态，与研究助理和临床量表的测量相比，将是有效和可靠的，并显示出非常好的重测可靠性。我们将初步开发家居 对于帕金森氏症患者，因为他们比其他任何神经疾病患者有更多的跌倒，但我们有信心这一工具将适用于任何形式的行动障碍，如多发性硬化症，中风，头部损伤，发育障碍，多感官缺陷，虚弱的老年人等。基于这项建议的结果，我们的第二阶段应用将测试家庭在药物或物理治疗改变后更快检测平衡和步态变化的能力，与通常的护理相比，为FDA的批准和广泛的营销做准备。

DESCRIPTION (provided by applicant): Although balance and gait disorders are one of the most common and devastating chronic medical problems of older people, especially those with chronic neurological diseases, clinicians or clinical researchers do not measure balance and gait frequently, accurately, or sensitively. Our long-term goal is to develop and commercialize a unique system called the Home Objective Mobility Exam (HOME) to allow patients to measure their own balance and gait at home. If physicians and physical therapists could obtain frequent, accurate, self-administered measures of balance and gait characteristics, then they will be able to earlier predict fall risk and changes in mobility. This will also enable them to quickly improve interventions in order to prevent mobility disability. The objective of this application is to deveop a novel method to allow patients to quantify their own standing balance, gait and turning with a quick, simple, and extremely easy to use system. The specifc aims are: Aim I. To develop a new version of the Opal movement monitor for home use. The objective of this aim is to transform the Opal sensors from a computer-based clinician/researcher-controlled system to a nonprofessional/patient-controlled system of movement monitoring. Aim II. To determine the feasibility, validity and reliability of having people with Parkinson's disease test their own balance and gait at home. We hypothesize that balance and gait, measured by patients in their homes, will be valid and reliable compared with measures administered by research assistants and with clinical scales and show very good test-retest reliability. We will initially develop HOME for patients with Parkinson's disease because they have more falls than any other neurological disorder, but we are confident that this tool will be useful for patients any form of mobility disability, such as multiple sclerosis, stroke, head injury, developmental disorders, multisensory deficits, frail elderly, etc. Based on results of this proposal, our Phase II application will thentest the ability of the HOME to more quickly detect changes in balance and gait following a change in medication or physical therapy, compared to usual care, in preparation for FDA approval and widespread marketing.