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Mobility Life: Monitoring Mobility in Daily Lives of People with Neurological Disease

移动生活：监测神经系统疾病患者日常生活中的移动能力

基本信息

批准号：
9202863
负责人：
Mahmoud El-Gohary
金额：
$ 180.55万
依托单位：
APDM, INC.
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-30 至 2019-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9202863
关键词：
Admission activity Adult Age Algorithms Ankle Bandage Businesses Cessation of life Clinic Clinical Clinical Research Collaborations Complex Consensus Databases Disease Progression Environment Equilibrium Fatigue Gait Goals Grant Health Sciences Home environment Hospitals Human Huntington Disease Impairment Injury Intervention Laboratories Length Life Marketing Measures Medical Mission Monitor Movement Movement Disorders Multiple Sclerosis Neurologic Neurologist Neurology Nursing Homes Oregon Organism Parkinson Disease Patient Monitoring Patients Performance Pharmaceutical Preparations Phase Preparation Quality of life Reference Values Reporting Research Personnel Severities Shoes Small Business Innovation Research Grant Stress System Technology Testing Universities Validation Visit Work age related base clinical practice disability experience fall risk falls foot improved innovation instrument interest light weight mild cognitive impairment nervous system disorder novel patient population physical therapist prospective response sensor technology development wearable technology

项目摘要

Project Summary Falls are the leading cause of injuries, hospital visits, nursing home admissions, and reduced quality of life for people with neurological disorders. Although there is consensus that impaired mobility is the basis for most falls, it is very diﬃcult to evaluate these complex abilities outside a laboratory setting. Brief clinical examinations do not accurately reﬂect daily, functional mobility in real life environments. Patients at risk of falls would beneﬁt from a system they can easily use to measure their daily mobility, assess mobility ﬂuctuations throughout the day, evaluate their risk of falling, and measure eﬀects of interventions aimed at improving their functional mobility and reducing their falls. No commercial technology yet exists to continuously monitor ﬂuctuations in mobility or quantify fall risk in natural environments during normal activities. We developed and validated an unobtrusive system, called Mobility Life, to objectively characterize gait and turning during spontaneous activities with wearable inertial sensors. During this Phase II, we will develop an instrumented ankle wrap for continuous monitoring of gait, develop a user interface to support clinical research, develop reports that show indications of fall risk for clinical practice, and thoroughly verify and validate our technology. We will also determine which metrics are most indicative of fall risk and determine normative values for non-fallers in the same age range as the expected patient populations. Our speciﬁc aims are: AIM I. Technology Development: Prepare Mobility Life for clinical practice. · Milestone 1: Develop an instrumented elastic ankle bandage (SmartSox) for continuous gait monitoring. · Milestone 2: Develop useful clinical reports to convey patients' daily mobility impairments, ﬂuctuations, and fall risk. · Milestone 3: Complete the system veriﬁcation and validation in preparation for FDA 510(k) clearance to market. Aim II. Clinical Research: Demonstrate the clinical utility of Mobility Life to monitor quality of functional mobility and fall risk in neurological patients. · Milestone 4: Determine which daily life mobility impairments best predict fall risk in patients with PD or MS. · Milestone 5: Develop reference values for integrity of functional mobility in healthy age-matched subjects.

项目总结