TOPAS: Fast and easy to use Monte Carlo system for proton therapy

TOPAS：快速且易于使用的质子治疗蒙特卡罗系统

• 批准号: 8578284
• 负责人: HARALD PAGANETTI
• 金额: $ 47.32万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8578284
• 关键词: Automobile Driving; Biological; Biological Models; Biology; Cellular biology; Charge; Chemicals; Clinic; Clinical; Collaborations; Communities; Complex; Computer software; DNA Damage; DNA lesion; Data; Dose; Engineering; Four-dimensional; Frequencies; Funding; Head; Health; Laboratories; Libraries; Mainstreaming; Medical; Modeling; Normal tissue morphology; Organ; Outcome; Patients; Pattern; Physics; Process; Protons; Publishing; Radiation; Radiation therapy; Radiobiology; Relative Biological Effectiveness; Research; Running; Simulate; Specialist; System; Techniques; Technology; Therapeutic; Time; Touch sensation; Tumor Tissue; Universities; base; effective therapy; flexibility; graphical user interface; imaging modality; improved; innovation; interdisciplinary collaboration; ionization; particle; proton beam; proton therapy; research study; simulation; success; tool; treatment planning

DESCRIPTION (provided by applicant): As proton therapy has joined the mainstream of radiation treatment, Monte Carlo simulation (MC) has been the research engine driving highly accurate dose delivery. The TOPAS Tool for Particle Simulation, developed in the previous funding cycle, makes MC accessible as never before. As radiation therapy pushes to the next challenge, where physics and biology come together, TOPAS will bridge the divide between these two research domains. TOPAS can track any kind of particle through any kind of treatment head, import a patient geometry, score dose, fluence, etc., has advanced graphics and scoring features, and is fully four-dimensional to handle all time-dependent aspects of a simulation. Research physicists use TOPAS to improve proton delivery systems towards safer and more effective treatments, easily setting up and running complex MC simulations that used to take MC specialists months to prepare. Clinical physicists use TOPAS to optimize the therapeutic ratio, simulating patient- specific treatment plans with the full accuracy of MC at the touch of a button. We will bring the same benefits to the radiobiological community. Where radiobiology research has previously suffered from insufficient interdisciplinary collaboration between physicists and biologists, TOPAS will bridge the gap. TOPAS will let biologists study detailed physics aspects of their experiments and let physicists employ the latest radiobiology results in the clinic. TOPAS will provide a common research platform to proton therapy facilities, biology laboratories and universities. Specific Aim 1: Expand TOPAS to facilitate research on organ effect biology a. Provide a framework for tumor and normal tissue outcome modeling b. Validate by reproducing published data on proton beam normal tissue complications Specific Aim 2: Expand TOPAS to facilitate research on cellular effect biology a. Provide a framework for cellular effect RBE modeling b. Validate by calculating the relative biological effectiveness f proton beams Specific Aim 3: Expand TOPAS to facilitate research on sub-cellular effect biology a. Provide a framework for sub-cellular effect mechanistic modeling b. Validate by reproducing data on ionization frequencies and DNA damage Specific Aim 4: Support and share TOPAS for all user communities a. Support current TOPAS user communities in proton therapy physics b. Reach out to new user communities in other therapy modalities and imaging c. Continuing software innovation, enhanced graphical user interfaces and beyond

描述（申请人提供）：随着质子治疗加入放射治疗的主流，蒙特卡罗模拟（MC）已经成为推动高精度剂量传递的研究引擎。在上一个资助周期中开发的TOPAS粒子模拟工具使MC前所未有地易于使用。随着放射治疗向物理学和生物学的下一个挑战推进，TOPAS将弥合这两个研究领域之间的鸿沟。TOPAS可以通过任何类型的治疗头跟踪任何类型的粒子，导入患者几何形状，评分剂量，影响等，具有先进的图形和评分功能，并且完全是四维的，可以处理所有与时间相关的模拟方面。研究物理学家使用TOPAS来改进质子输送系统，以实现更安全和更有效的治疗，轻松地设置和运行复杂的MC模拟，而MC专家过去需要花费数月的时间来准备。临床物理学家使用TOPAS来优化治疗比例，模拟患者特定的治疗计划，完全准确的MC