Stress Reactivity and Substance Use among Sexual Minority Girls

性少数女孩的应激反应和药物使用

基本信息

批准号：
8416635
负责人：
Deena Chisolm
金额：
$ 33.99万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-02-01 至 2018-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8416635
关键词：
Acute Address Adolescence Affective African American Age Alcohol or Other Drugs use Alcohols Automobile Driving Biological Markers Bisexual Chronic Chronic stress Data Development Discrimination Drug usage Emotional Emotional Stress Event Exhibits Female Adolescents Frequencies Functional disorder Gays Goals HIV risk Health Heterosexuals Intervention Laboratories Lesbian Link Literature Longitudinal Studies Marshal Mediating Mediator of activation protein Mental Depression Mental Health Meta-Analysis Methodology Minority Modeling Moods Neurocognitive Outcome Parents Pathway interactions Patient Self-Report Physiological Play Prevention program Preventive Intervention Process Public Health Publishing Recruitment Activity Regulation Relative (related person)Reporting Research Risk Risk Behaviors Schools Scientist Sex Behavior Simulate Social Impacts Staging Strategic Planning Stress Study Section Substance abuse problem Suicide Testing Time Validation Victimization Violence Vulnerable Populations Youth acute stress adolescent substance use assault base behavioral health biological adaptation to stress bullying design emotional reaction experience girls health disparity innovation intervention program novel prospective psychosocial public health relevance reduced substance use response sex sexual minority social stressor theories young adult

项目摘要

DESCRIPTION (provided by applicant): The central goal of this study is to examine physiological and emotional reactivity to social and gay- related stressors among sexual minority girls (SMGs; girls who report same-sex attraction, same-sex sexual behavior, and/or a bisexual or lesbian identity), and their prospective associations with substance use and abuse. Minority Stress Theory (MST; Meyer, 2003) asserts that discrimination, violence, and victimization are the primary driving mechanisms of substance use and other mental health disparities among SMGs. Several recent studies published by the proposed PI support this hypothesis. Meta-analysis results showed that compared with heterosexual girls, SMGs were 400% more likely to have used drugs and alcohol (Marshal et al 2008), and trajectory analyses show that this disparity is likely to increase as SMGs transition to young adulthood (Marshal et al 2009, 2012). Two other studies showed that compared with heterosexual girls, SMGs were almost 300% more likely to experience suicidality and over 300% more likely to report being assaulted at school (Friedman, Marshal, et al., 2011; Marshal et al, 2011). This study will recruit 120 adolescent girls ages 14-18 (50% SMGs, 50% African-American) to address the proposed aims. We are proposing a modified minority stress model, asserting that physiological and emotional stress reactivity are important components of the minority stress process, and mediators of the pathway to substance use and other mental health outcomes among SMGs. Our specific aims are to: (1) use ecological momentary assessment (EMA) to document the daily social and gay-related stressors examine the "real time" links between these stressors and substance use, depression, and HIV risk behavior; (2) determine whether SMGs exhibit altered physiological and subjective responses to lab-based social and gay-related stress tasks; and (3) determine whether chronic stress exposure and biomarkers of stress reactivity predict long-term substance use, HIV risk behaviors, and other mental health outcomes. This will be the first study to assess, document, and describe stress reactivity processes among SMGs using lab-based and ecologically valid EMA methodologies. There are no empirically supported substance use interventions for sexual minority youth. Results from this study will accelerate progress towards the development of much needed prevention and intervention programs for SMGs at risk.

描述（由申请人提供）：这项研究的核心目的是检查性少数女孩（SMG；报告同性吸引力，同性性行为同性性行为以及/或双性恋或同性恋身份）的生理和情感反应性，以及与物质使用和滥用的前瞻性关联。少数派压力理论（MST; Meyer，2003）断言，歧视，暴力和受害是SMG中药物使用和其他心理健康差异的主要驾驶机制。拟议的PI发表的一些最新研究支持了这一假设。荟萃分析结果表明，与异性恋女孩相比，使用药物和酒精的可能性高400％（Marshal等，2008），而轨迹分析表明，随着SMGS过渡到年轻成年期，这种差异可能会增加（Marshal等人2009，2012）。另外两项研究表明，与异性恋女孩相比，SMG经历自杀性的可能性几乎高300％，并且报告在学校遭到殴打的可能性高300％（Friedman，Marshal等，2011; Marshal等，2011）。这项研究将招募 120名14-18岁的青少年女孩（50％SMG，50％的非裔美国人）来解决拟议的目标。我们提出了一个修改的少数族裔压力模型，断言生理和情绪压力反应是少数族裔压力过程的重要组成部分，也是SMG中物质使用途径和其他心理健康结果的介体。我们的具体目的是：（1）使用生态瞬时评估（EMA）记录日常社会和同性恋相关的压力源检查这些压力源与药物使用，抑郁和HIV风险行为之间的“实时时间”联系；（2）确定SMG是否对基于实验室的社会和同性恋相关的压力任务表现出改变的生理和主观反应；（3）确定慢性压力暴露和压力反应性的生物标志物是否可以预测长期使用物质，艾滋病毒风险行为和其他心理健康结果。这将是首次使用基于实验室和生态有效的EMA方法来评估，记录和描述SMG之间的压力反应过程的研究。对于性少数青年，没有经验支持的药物使用干预措施。这项研究的结果将加速进步，以开发急需的预防和干预计划，以使SMG处于危险之中。