Individual Nutrition Therapy and Exercise Regime: A Controlled Trial of Injured, Vulnerable Elderly (INTERACTIVE trial).

个体营养治疗和运动制度：受伤、弱势老年人的对照试验（互动试验）。

• 批准号: nhmrc : 426758
• 负责人: A/Pr Craig Whitehead
• 金额: $ 38.18万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/individual-nutrition-therapy-interactive-trial/95141
• 关键词: Individual; Nutrition; Therapy; Exercise; Regime

Hip fractures are a common and growing problem for older Australians. Unfortunately recovery is incomplete in most people. In this study two factors believed to be important for recovery will be investigated - exercise and nutrition. After a hip fracture the ability to walk is severely compromised, as are appetite and dietary intake. These factors are likely to contribute to the loss of muscle mass and strength frequently observed amongst this patient group. There is considerable evidence to suggest that this loss has serious consequences in terms of ability to return to pre-injury levels of function, restriction in independence and ultimately transfer into a hostel or nursing home. Given these facts it makes sense that an exercise program incorporating strength and functional activities, and a nutrition program aimed at achieving nutritional requirements, will improve ability to walk, but there is no conclusive evidence that this is so. Only a small number of studies have tested whether an exercise program improves recovery after a hip fracture and these have mostly commenced weeks or months after the injury when it is likely that there has been irreversible decline in muscle mass and strength. In contrast, most of the nutrition studies commence soon after the injury but provide protein and calories insufficient to meet requirements, provide supplements that patients find difficult to drink or provide the supplements for only a short duration. This study will use the best quality research methods to test whether providing a 6-month individualised exercise and nutrition program to hip fracture patients soon after injury improves walking and other important health outcomes. Patients will be followed for 12 months to determine what difference the exercise and nutrition programs make. If they help then health services will have the evidence they need to recommend this type of program to the growing number of older Australians that suffer a hip fracture.

髋部骨折是澳大利亚老年人常见且日益严重的问题。不幸的是，大多数人的恢复是不完整的。在这项研究中，两个因素被认为是重要的恢复将被调查-运动和营养。髋部骨折后，行走能力严重受损，食欲和饮食摄入也严重受损。这些因素可能导致在该患者组中经常观察到的肌肉质量和力量的损失。有相当多的证据表明，这种损失有严重的后果，在能力恢复到受伤前的功能水平，独立性的限制，并最终转移到宿舍或疗养院。考虑到这些事实，结合力量和功能活动的锻炼计划以及旨在实现营养需求的营养计划将改善行走能力是有道理的，但没有确凿的证据表明这是如此。只有少数研究测试了锻炼计划是否能改善髋部骨折后的恢复，这些研究大多在受伤后几周或几个月开始，当时肌肉质量和力量可能已经不可逆转地下降。相比之下，大多数营养研究在受伤后不久就开始了，但提供的蛋白质和热量不足以满足需求，提供的补充剂患者难以饮用或仅提供短期补充剂。这项研究将使用最高质量的研究方法来测试是否为髋部骨折患者提供为期6个月的个性化运动和营养计划，以改善行走和其他重要的健康结果。患者将被随访12个月，以确定运动和营养计划有什么不同。如果他们提供帮助，那么卫生服务部门将有足够的证据向越来越多的髋部骨折的澳大利亚老年人推荐这种项目。