Symposium on Obesity and Transplantation: Comparing Medical Nutrition Therapy, Pharmacotherapy, and Bariatric Surgery

肥胖与移植研讨会：医学营养疗法、药物疗法和减肥手术的比较

• 批准号: 10828092
• 负责人: Heather Marie Gardiner
• 金额: $ 5万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-30 至 2024-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10828092
• 关键词: Symposium; Obesity; Transplantation; Comparing; Medical

PROJECT SUMMARY Obesity continues to be a significant barrier to solid organ transplantation. Patients with obesity awaiting kidney, liver, and heart transplantation are often delayed or denied transplants until weight loss is achieved. We propose a research development conference to review and discuss the evidence-base and current practices surrounding the use of medical nutritional therapy, pharmacotherapy, and bariatric surgery to support patients' weight loss prior to solid organ transplantation. The proposed Symposium on Obesity and Solid Organ Transplantation: The Role of Medical Nutrition Therapy, Pharmacotherapy, and Bariatric Surgery, will convene a multidisciplinary group of clinicians, researchers and allied health professionals (i.e., social workers, nutritionists, dieticians) in the fields of solid organ transplantation and obesity as well as patients with obesity awaiting transplantation to develop an agenda for future comparative effectiveness research at the intersection of these fields and develop strategies for reducing delays in the receipt of life-saving and life-changing transplants and wait list mortality for patients with obesity. The proposed research development conference builds on our successful AHRQ-funded Symposium on Obesity and Kidney Transplantation held in May of 2021 (R13HS028377). This inaugural hybrid event garnered 486 registrants and 317 attendees; the meeting also generated 56 research questions and overwhelmingly positive reviews. The proposed conference expands on this inaugural event and aims to: 1) elicit patient perspectives on and experiences with regarding the challenges and successes of weight loss and management in preparation for kidney, liver and heart transplantation; 2) provide a forum for sharing research findings and clinical experience related to the use of medical nutritional therapy, pharmacotherapy, and bariatric surgery to address obesity prior to transplantation; 3) generate a research agenda, including specific research questions, to investigate issues related to obesity and transplantation. We propose to organize, advertise, implement and evaluate the symposium, and disseminate the resulting content in collaboration with our existing Steering Committee. In addition, three patients who have been evaluated and waitlisted for kidney, liver, lung, or heart transplantation and who concurrently suffer from obesity that is delaying transplantation will be recruited as patient partners to serve as members of the Steering Committee. Three additional patient partnerss will serve as symposium panelists and will share personal experience with weight loss as a transplant candidate to an audience of clinicians, researchers and allied health professionals. Our anticipated outcomes include a manuscript from the symposium content and discussions, and an agenda with specified research questions for future comparative effectiveness research on the use of medical nutritional therapy, pharmacotherapy, and bariatric surgery to treat obesity prior to solid organ transplantation.

项目概要 肥胖仍然是实体器官移植的重大障碍。肥胖患者等待 肾脏、肝脏和心脏移植常常被推迟或拒绝移植，直到达到减肥效果。 我们提议召开一次研究开发会议来审查和讨论证据基础和当前的 围绕使用医学营养疗法、药物疗法和减肥手术来支持的实践 实体器官移植前患者体重减轻。拟议的肥胖与固体研讨会 器官移植：医学营养治疗、药物治疗和减肥手术的作用，将 召集一个由临床医生、研究人员和专职医疗专业人员（即社会工作者、 实体器官移植和肥胖领域的营养师（营养师）以及肥胖患者 等待移植以制定未来交叉点比较有效性研究的议程 并制定战略，减少接收挽救生命和改变生活的物资方面的延误 肥胖患者的移植和等待名单死亡率。拟议的研究发展会议 建立在我们于 2019 年 5 月成功举办的由 AHRQ 资助的肥胖和肾脏移植研讨会的基础上 2021（R13HS028377）。首届混合活动吸引了 486 名注册者和 317 名与会者；会议 还产生了 56 个研究问题和绝大多数积极的评论。拟议的会议 扩展了这一首次活动，旨在：1) 激发患者对以下方面的看法和经验： 为肾脏、肝脏和心脏做好准备的减肥和管理的挑战和成功 移植； 2）提供一个分享与使用相关的研究成果和临床经验的论坛 在移植前解决肥胖问题的医学营养疗法、药物疗法和减肥手术； 3）制定研究议程，包括具体的研究问题，以调查与肥胖相关的问题 和移植。我们提议组织、宣传、实施和评估研讨会，并 与我们现有的指导委员会合作传播最终的内容。此外，三 已接受肾、肝、肺或心脏移植评估并列入候补名单的患者 同时患有肥胖症而导致移植延迟的患者将被招募为患者伙伴，作为患者的伴侣 指导委员会成员。另外三名患者伙伴将担任研讨会小组成员 将向临床医生观众分享作为移植候选者的减肥个人经验， 研究人员和专职医疗专业人员。我们的预期成果包括来自 研讨会内容和讨论，以及包含未来比较的具体研究问题的议程 使用医学营养疗法、药物疗法和减肥手术的有效性研究 在实体器官移植之前治疗肥胖。