Determinants of Drug Preference in Humans--Administrative Supplement

描述(由申请人提供)：该项目旨在调查滥用药物对具有积极或消极情绪效价的刺激的情感反应的影响。这些研究探索了一种假设，即药物调节对情感刺激的反应，而这些效应反过来又影响药物的主观或强化效果。我们将研究兴奋剂、酒精和大麻素对情感反应的急性效应之间的双向交互作用。这些研究特别关注对具有社会内容的刺激的情感反应，以调查药物影响社会刺激的知觉和效价的想法。我们将评估药物对正面或负面视觉图像的反应的影响，包括具有社会或非社会内容的图像。此外，我们还将调查毒品在现实生活中积极或消极的社会情境中的作用.在所有研究中，我们都会比较男性和女性的这些情绪反应。这种创新的方法在神经精神药理学和情感神经科学领域之间架起了桥梁，如果成功，将扩大我们对导致强迫寻求药物行为的过程的理解。

DESCRIPTION (provided by applicant): This project is designed to investigate the effects of drugs of abuse on affective responses to stimuli with positive or negative emotional valence. The studies explore the hypothesis that drugs modulate responses to affective stimuli, and that these effects, in turn, influence the drugs' subjective or reinforcing effects. We will study bidirectional interactions between acute effects of stimulants, alcohol and cannabinoids on affective responses. The studies focus in particular on affective responses to stimuli with social content, to investigate the idea that drugs influence the perception and valence of social stimuli. We will assess the effects of drugs on responses to positive or negative visual images, including images with social or nonsocial content. In addition, we will investigate drug the effects of drugs in real-life positive or negative social situations. In all studies we will compare these emotional responses in men and women. This innovative approach bridges the area of neuropsychopharmacology with affective neuroscience, and if successful, will extend our understanding of the processes that lead to compulsive drug-seeking behavior.