2011-15 FASEB Summer Conference on Autoimmunity

描述（由申请人提供）：在过去的几年里，我们对自身免疫的致病机制的理解有了巨大的增长，并且对不同自身免疫性疾病之间的相似性和重要差异有了新的认识。自身免疫研究领域快速发展的例子是鉴定和表征分泌独特炎症介质的致病性T细胞的新亚群，以及对遗传易感性、环境压力和微生物组之间界面的新见解。这些发现主要来自基础科学家的工作，而FASEB关于自身免疫的夏季会议历来专注于讨论自身免疫基础研究的新发现。然而，我们认为，基础科学家与致力于将机制转化为治疗目标的科学家建立和保持联系至关重要。例如，治疗性B细胞耗竭在某些自身免疫性疾病中的意想不到的功效促使基础科学家对B细胞在致病途径中的作用进行深入研究。因此，在保持对自身免疫性前沿基础研究的关注的同时，这些会议将包括新的会议，邀请翻译科学家讨论用生物制剂治疗自身免疫性疾病的新策略，以及操纵自身免疫性疾病人类免疫系统的成功和失败的当前数据。我们预计，对自身免疫性疾病治疗的日益重视将吸引基础和行业科学家，并将激发初级和成熟研究人员的强烈兴趣。本次会议的规模和设置是理想的，以促进开放的数据交换和思想的交叉施肥，这将刺激新的假设和方向，在自身免疫研究。 公共卫生相关性：自身免疫性疾病是使人衰弱的慢性疾病，导致生活质量显著下降。在过去十年中，自身免疫的发病率已经上升，使得这些疾病由于生计损失和医疗保健成本而共同对社会造成重大的经济损失。FASEB自身免疫夏季会议的目标是为基础和应用科学家之间的数据，想法和假设交流提供一个论坛，以促进自身免疫性疾病新疗法的开发。

DESCRIPTION (provided by applicant): There has been enormous growth in the past few years in our understanding of pathogenic mechanisms in autoimmunity, and a new recognition of the similarities and important differences between different autoimmune diseases. Examples of rapidly moving areas of research in autoimmunity are the identification and characterization of new subsets of pathogenic T cells that secrete unique inflammatory mediators and novel insights into the interface between genetic susceptibility, environmental stress and the microbiome. These findings have emerged largely from the work of basic scientists, and this FASEB summer conference on Autoimmunity has historically focused on discussion of new findings in basic research in autoimmunity. However, we believe that it is crucial for basic scientists to establish and maintain connections to scientists who are working to translate mechanisms into therapeutic targets. For example, the unexpected efficacy of therapeutic B cell depletion in some autoimmune diseases has prompted intense investigation by basic scientists into the role of B cells in pathogenic pathways. Therefore, while maintaining a focus on cutting edge basic research in autoimmunity, new sessions will be included in these conferences in which translational scientists are invited to discuss new strategies for treating autoimmune diseases with biologics, and current data on the successes and failures of manipulating the immune system in humans with autoimmune disease. We expect that increased emphasis on therapeutic treatment of autoimmune disease will attract both basic and industry scientists, and will stimulate strong interest among both junior and established investigators. The size and setting of this meeting are ideal to promote the open exchange of data and cross-fertilization of ideas that will stimulate new hypotheses and directions in autoimmunity research. PUBLIC HEALTH RELEVANCE: Autoimmune diseases are debilitating, chronic diseases resulting in significant decrease in quality of life. The incidence of autoimmunity has risen over the past decade such that collectively these disease exert a significant economic toll on society due to loss of livelihood and cost of health care. The goal of the FASEB Summer Conferences on Autoimmunity is to provide a forum for the exchange of data, ideas and hypotheses between basic and applied scientists in order to catalyze the development of new treatments for autoimmune diseases.