2011-15 FASEB Summer Conference on Autoimmunity

描述(由申请人提供)：在过去的几年里，我们对自身免疫的致病机制的了解有了巨大的增长，并对不同的自身免疫疾病之间的相似和重要区别有了新的认识。自身免疫研究领域迅速发展的例子包括识别和表征分泌独特炎症介质的新的致病T细胞亚群，以及对遗传易感性、环境应激和微生物组之间的界面的新见解。这些发现在很大程度上是由基础科学家的工作产生的，这次FASE B关于自身免疫的夏季会议历史上一直专注于讨论自身免疫基础研究的新发现。然而，我们认为，对于基础科学家来说，与致力于将机制转化为治疗靶点的科学家建立和保持联系是至关重要的。例如，在一些自身免疫性疾病中，治疗性B细胞耗尽的意想不到的效果促使基础科学家对B细胞在致病途径中的作用进行了深入的研究。因此，在保持对自身免疫前沿基础研究的关注的同时，这些会议将包括新的会议，在这些会议上，翻译科学家被邀请讨论用生物制剂治疗自身免疫疾病的新策略，以及关于操纵患有自身免疫疾病的人类免疫系统的成功和失败的最新数据。我们预计，对自身免疫性疾病治疗方法的日益重视将吸引基础和行业科学家，并将激发初级和老牌研究人员的浓厚兴趣。这次会议的规模和环境是促进开放数据交换和思想交流的理想选择，这将刺激自身免疫研究的新假设和新方向。 公共卫生相关性：自身免疫性疾病是使人虚弱的慢性疾病，导致生活质量显著下降。在过去十年中，自身免疫性疾病的发病率有所上升，因此，由于生计损失和保健费用的降低，这些疾病共同对社会造成了巨大的经济损失。FASEB关于自身免疫的夏季会议的目标是为基础科学家和应用科学家之间交换数据、想法和假设提供一个论坛，以促进自身免疫性疾病新疗法的开发。

DESCRIPTION (provided by applicant): There has been enormous growth in the past few years in our understanding of pathogenic mechanisms in autoimmunity, and a new recognition of the similarities and important differences between different autoimmune diseases. Examples of rapidly moving areas of research in autoimmunity are the identification and characterization of new subsets of pathogenic T cells that secrete unique inflammatory mediators and novel insights into the interface between genetic susceptibility, environmental stress and the microbiome. These findings have emerged largely from the work of basic scientists, and this FASEB summer conference on Autoimmunity has historically focused on discussion of new findings in basic research in autoimmunity. However, we believe that it is crucial for basic scientists to establish and maintain connections to scientists who are working to translate mechanisms into therapeutic targets. For example, the unexpected efficacy of therapeutic B cell depletion in some autoimmune diseases has prompted intense investigation by basic scientists into the role of B cells in pathogenic pathways. Therefore, while maintaining a focus on cutting edge basic research in autoimmunity, new sessions will be included in these conferences in which translational scientists are invited to discuss new strategies for treating autoimmune diseases with biologics, and current data on the successes and failures of manipulating the immune system in humans with autoimmune disease. We expect that increased emphasis on therapeutic treatment of autoimmune disease will attract both basic and industry scientists, and will stimulate strong interest among both junior and established investigators. The size and setting of this meeting are ideal to promote the open exchange of data and cross-fertilization of ideas that will stimulate new hypotheses and directions in autoimmunity research. PUBLIC HEALTH RELEVANCE: Autoimmune diseases are debilitating, chronic diseases resulting in significant decrease in quality of life. The incidence of autoimmunity has risen over the past decade such that collectively these disease exert a significant economic toll on society due to loss of livelihood and cost of health care. The goal of the FASEB Summer Conferences on Autoimmunity is to provide a forum for the exchange of data, ideas and hypotheses between basic and applied scientists in order to catalyze the development of new treatments for autoimmune diseases.