Mathematical Techniques for Control of Epidemic Trypanosoma cruzi Transmission

描述（由申请人提供）：查加斯病由单细胞寄生虫克氏锥虫引起，是一种可预防的疾病。然而，美洲死于恰加斯病的人比死于任何其他寄生虫感染的人都多。本申请将为申请人提供宾夕法尼亚大学和约翰霍普金斯大学彭博公共卫生学院数学建模和现代计算机科学方面的辅导培训。培训将着眼于发展必要的技能，以解决阻碍控制南美锥虫病的复杂问题。这项研究的长期目标是将T。cruzi感染纳入控制方案，主要侧重于消灭病媒，并更好地指导消灭病媒运动。除了在美国进行的辅导培训外，还将在秘鲁进行昆虫学和临床研究。 福格蒂国际中心致塞萨尔·纳奎拉博士及其合作者。阿雷基帕是秘鲁南部的一个近百万居民的城市。cruzi和恰加斯病已经成为城市问题。查加斯病感染的悄悄流行正在全市蔓延。本申请的具体目标是：1）开发技术，以了解和控制T。克氏病毒在疫情中的传播; 2.优化南美锥虫病病媒控制的时空顺序 在阿雷基帕开展的病媒防治运动中，还将阐明其他地方病媒控制的最佳做法战略。在开发这些数学技术的候选人将接受定量培训，这将补充他以前的工作传染病，并允许他发展成为一个全面的独立调查员。相关性：将儿童克氏锥虫感染的诊断纳入南美锥虫病防治运动，有可能大大降低秘鲁和其他地方南美锥虫病的发病率和死亡率。优化病媒控制活动的时空顺序可以增加消除克氏锥虫未来传播的可能性。

DESCRIPTION (provided by applicant): Chagas disease, caused by the unicellular parasite Trypanosoma cruzi, is a preventable disease. Nevertheless more people in the Americas die from Chagas disease than any other parasitic infection. This application will provide tutorial-based training to the applicant in mathematical modeling and modern computer science at the University of Pennsylvania and the Bloomberg School of Public Health of Johns Hopkins University. Training will be geared towards developing the skills necessary to address complex problems hindering the control of Chagas disease. The long term goal of the research is to integrate diagnostic testing of children at high risk of T. cruzi infection into control programs focused mainly on vector elimination, and to better guide vector elimination campaigns. In addition to tutorial-based training in the United States, entomologic and clinical research will be conducted in Peru in coordination with a research grant awarded by the Fogarty International Center to Dr. Cesar Naquira and collaborators. In Arequipa, a city of nearly one million inhabitants in southern Peru, T. cruzi and Chagas disease have become urban problems. A quiet epidemic of Chagas disease infection is progressing across the city. The specific aims of this application are: 1) To develop techniques to understand and control T. cruzi transmission in epidemic situations, and, 2. To optimize the spatio-temporal ordering of the Chagas disease vector control campaign in Arequipa, and to elucidate best-practice strategies for vector control elsewhere. In developing these mathematical techniques the candidate will receive quantitative training that will complement his previous work on infectious disease and allow him to develop into a well-rounded independent investigator. RELEVANCE: Integrating diagnosis of children for T cruzi infection into Chagas control campaigns has the potential to greatly reduce morbidity and mortality due to Chagas disease in Peru and elsewhere. Optimizing the spatio-temporal order of vector control campaigns can increase the probability that these eliminate future transmission of T cruzi.