Mathematical Techniques for Control of Epidemic Trypanosoma cruzi Transmission
控制流行性克氏锥虫传播的数学技术
基本信息
- 批准号:8279285
- 负责人:
- 金额:$ 10.52万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-07-15 至 2013-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAlgorithmsAmericasAreaAwardBrazilCapitalChagas DiseaseChildChileCitiesClinical ResearchCommunicable DiseasesCommunitiesComplementComplexDiagnosisDiagnosticDiagnostic testsDiseaseDisease VectorsEcologyEmpirical ResearchEpidemicFutureGoalsGrantHealthHousingInfectionInfection ControlInsect VectorsInsecticidesKnowledgeMachine LearningMentorsModelingMorbidity - disease rateParasitesParasitic infectionPatientsPatternPennsylvaniaPeruPopulationPositioning AttributePrincipal InvestigatorProbabilityProtocols documentationPublic HealthPublic Health SchoolsResearchResearch InfrastructureResearch PersonnelResearch Project GrantsResidual stateRetinal ConeRunningRuralSolutionsSouth AmericaTechniquesTrainingTriatomaTropical MedicineTrypanosoma cruziTuberculosisUnited StatesUniversitiesWorkbasechemotherapycomputer sciencedisease transmissiondisorder controlhigh riskinternational centerkillingsmathematical modelmortalitynovelprogramspyrethroidrural areaskillssuccesstheoriestransmission processurban areavectorvector control
项目摘要
DESCRIPTION (provided by applicant): Chagas disease, caused by the unicellular parasite Trypanosoma cruzi, is a preventable disease. Nevertheless more people in the Americas die from Chagas disease than any other parasitic infection. This application will provide tutorial-based training to the applicant in mathematical modeling and modern computer science at the University of Pennsylvania and the Bloomberg School of Public Health of Johns Hopkins University. Training will be geared towards developing the skills necessary to address complex problems hindering the control of Chagas disease. The long term goal of the research is to integrate diagnostic testing of children at high risk of T. cruzi infection into control programs focused mainly on vector elimination, and to better guide vector elimination campaigns. In addition to tutorial-based training in the United States, entomologic and clinical research will be conducted in Peru in coordination with a research grant awarded by
the Fogarty International Center to Dr. Cesar Naquira and collaborators. In Arequipa, a city of nearly one million inhabitants in southern Peru, T. cruzi and Chagas disease have become urban problems. A quiet epidemic of Chagas disease infection is progressing across the city. The specific aims of this application are: 1) To develop techniques to understand and control T. cruzi transmission in epidemic situations, and, 2. To optimize the spatio-temporal ordering of the Chagas disease vector control
campaign in Arequipa, and to elucidate best-practice strategies for vector control elsewhere. In developing these mathematical techniques the candidate will receive quantitative training that will complement his previous work on infectious disease and allow him to develop into a well-rounded independent investigator. RELEVANCE: Integrating diagnosis of children for T cruzi infection into Chagas control campaigns has the potential to greatly reduce morbidity and mortality due to Chagas disease in Peru and elsewhere. Optimizing the spatio-temporal order of vector control campaigns can increase the probability that these eliminate future transmission of T cruzi.
描述(由申请人提供):查加斯病由单细胞寄生虫克氏锥虫引起,是一种可预防的疾病。然而,美洲死于恰加斯病的人比死于任何其他寄生虫感染的人都多。本申请将为申请人提供宾夕法尼亚大学和约翰霍普金斯大学彭博公共卫生学院数学建模和现代计算机科学方面的辅导培训。培训将着眼于发展必要的技能,以解决阻碍控制南美锥虫病的复杂问题。这项研究的长期目标是将T。cruzi感染纳入控制方案,主要侧重于消灭病媒,并更好地指导消灭病媒运动。除了在美国进行的辅导培训外,还将在秘鲁进行昆虫学和临床研究,并将与联合国提供的研究赠款协调进行。
福格蒂国际中心致塞萨尔·纳奎拉博士及其合作者。阿雷基帕是秘鲁南部的一个近百万居民的城市。cruzi和恰加斯病已经成为城市问题。查加斯病感染的悄悄流行正在全市蔓延。本申请的具体目标是:1)开发技术,以了解和控制T。克氏病毒在疫情中的传播; 2.优化南美锥虫病病媒控制的时空顺序
在阿雷基帕开展的病媒防治运动中,还将阐明其他地方病媒控制的最佳做法战略。在开发这些数学技术的候选人将接受定量培训,这将补充他以前的工作传染病,并允许他发展成为一个全面的独立调查员。相关性:将儿童克氏锥虫感染的诊断纳入南美锥虫病防治运动,有可能大大降低秘鲁和其他地方南美锥虫病的发病率和死亡率。优化病媒控制活动的时空顺序可以增加消除克氏锥虫未来传播的可能性。
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Spatial and temporal patterns in Cimex lectularius (Hemiptera: Cimicidae) reporting in Philadelphia, PA.
宾夕法尼亚州费城报告的温带臭虫(半翅目:臭虫科)的空间和时间模式。
- DOI:10.1603/me13120
- 发表时间:2014
- 期刊:
- 影响因子:2.1
- 作者:Mabud,TarubS;Barbarin,AlexisM;Barbu,CorentinM;Levy,KatelynH;Edinger,Jason;Levy,MichaelZ
- 通讯作者:Levy,MichaelZ
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Michael Z Levy其他文献
A new chapter for an integrated rabies research, surveillance, prevention and control in Colombia: the commitment of the Rabies In The Americas (RITA) conference 2023
哥伦比亚狂犬病综合研究、监测、预防和控制的新篇章:2023 年美洲狂犬病 (RITA) 会议的承诺
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Estima;Jordan Edgardo BERMúDez Casillas;Alfredo Mejia Solis;Sandriana Ramos;Cintia Pinto;Da Silva;Iamamoto Nogi;Iana Suly;Santos Katz;Karina Ribeiro;Gerardo Santamaria Romero;Andrea Del;Hurtado Cruz;Diana Patricia Dallos Rodríguez;Francy Paola;Monroy Álvarez;Verónica Rincón Forero;Zulma Roció;Suarez Moreno;Jose Manuel Granados;Jorge Ossa;Leonardo Ladino;Zaida Liliana Cardenas;Yanira Chaparro;Oscar Sua;Diana Calderon;Eric I Tsao;Jerlyn K. Sponseller;L. Kibet;James Nayetuni;Terence Scott;Thais Vila;Zulma Rojas;D. Streicker;Verónica Yung;A. Broos;Haris Malik;Michelle Lineros;Julio Benavides;Latin Chile;America;Holly Crompton;Cassiano Vict ӓ ia;R. S. Magalhaes;Parlo Cesar;St. Vil;da Fonseca;F. Y. N. D. Vale;Sara de Souza Pereira;Vinicius Pacheco;Cássia N. S. Moraes;P. F. D. C. Vasconcelos;Livia Medeiros;Neves Casseb;Otávio Cabral;Dr. Alan C. Jackson;Dr. Catherine Filejski;Dr. Juan Antonio;Montaño Hirose Independent Virology;Biosafety Advisor;Tecámac;Dr. Marcelo Yoshito Wada;Dr. Baltazar Cortés García;Dr. Peter J. Costa;Dr. Rosely Cerqueira;de Oliveira Dr;Dennis Donovan Dr;Diódoro Batalla;Emeritus Members Dr;Susan Nadin;Dr. Chris Nunan;D. Slate;Dr. Roly Tinline;Dr. Fernando Vargas Pino;Dr. Alex Wandeler;Dr. Cristhian Cabra;Dr. Paula Bermúdez;Dr. Luis Carlos;Villamil Dr. Ernesto;Dalmau Dr. Natalia;C. Nathalia;Méndez Dr. Juan David;Corrales Dr;Dalmau Dr. Paula Maria;Bermúdez;Dr. Juliana Gonzalez;Obando Dr. Julián;Ruiz Saenz Dr;Wilmer Ernesto;Villa;Luis Alberto;Carreño Buitrago Dr;Carlos Manuel;Rivera Forero Dr;Ángela Castro Dr;Cecilia Saad;Acosta Dr. Diana;Cristina Sánchez Dr;Paola Barato Gómez Dr;Nathalia Maria del Pilar Correa;Jairo Hernandez Márquez Dr;Luis Polo Dr - 通讯作者:
Luis Polo Dr
Incorporating Queueing Theory into a Spatial Optimization Framework to Improve Mass Vaccination Programs
将排队论纳入空间优化框架以改进大规模疫苗接种计划
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Sherrie Xie;M. Rieders;Srisa Changolkar;B. Bhattacharya;Elvis W Díaz;Michael Z Levy;R. Castillo;Blockley Hall - 通讯作者:
Blockley Hall
How modelling can help steer the course set by the World Health Organization 2021-2030 roadmap on neglected tropical diseases [version 1; peer review: awaiting peer review]
建模如何帮助引导世界卫生组织 2021-2030 年被忽视的热带病路线图设定的路线 [第 1 版;
- DOI:
- 发表时间:
2021 - 期刊:
- 影响因子:0
- 作者:
Antillon;Benjamín;F.;Arnold;Robin;L.;Bailey;Seth;Blumberg;Anna Borlasse;U. C. Braae;María Soledad;Castaño;Joel;Changalucha;Nakul;Chitnis;Sarah;Cleaveland;Ronald E Crump;Derek A. T. Cummings;Christopher;Davis;Emma;Michael;Deiner;Brecht;Devleesschauwer;Andy;Dobson;Daniel;Engelman;Neil;Ferguson;Claudio;Fronterre;Gabriël;Federica;Giardina;William;Godwin;Sébastien;Gourbière;Jonathan I D Hamley;Wendy Harrison;Alex;Holmes;Ching;Huang;Maria;Johansen;J. Kaldor;M. Keeling;Charles H. King;Lea;Knopf;P. Kontoroupis;E. Rutte;Justín;Lessler;Michael Z Levy;Thomas M Lietman;Kennedy;Lushasi;Mary;Verónica;Malizia;Jodie;McVernon;Edwin Michael;Philip Milton;Elizabeth Miranda;Eric;Q.;Mooring;Pierre;Nouvellet;David;Pigott;Travis;C.;Porco;Jorge E. Rabinovich;Sylvia Ramiandrasoa;Isabel;Rodriguez;K. Rysava;V. Schmidt;Morgan;E.;Smith;Andrew;Steer;Michelle;Stanton;F. Tediosi;T. Tenzin;S. M. Thumbi;Tildesley;Panayiota Touloupou;C. Trevisan;Caroline;Trotter;I. V. Damme;Carolin Vegvari;Juan;Villar;S. J. Vlas;Martin Walker;Ryan Wallace;A. S. Winkler;Peter Winskil - 通讯作者:
Peter Winskil
Michael Z Levy的其他文献
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{{ truncateString('Michael Z Levy', 18)}}的其他基金
An immune system for the city: a new paradigm for control of urban disease vectors
城市免疫系统:控制城市疾病媒介的新范例
- 批准号:
10204941 - 财政年份:2019
- 资助金额:
$ 10.52万 - 项目类别:
An immune system for the city: a new paradigm for control of urban disease vectors
城市免疫系统:控制城市疾病媒介的新范例
- 批准号:
10642860 - 财政年份:2019
- 资助金额:
$ 10.52万 - 项目类别:
An immune system for the city: a new paradigm for control of urban disease vectors
城市免疫系统:控制城市疾病媒介的新范例
- 批准号:
10436196 - 财政年份:2019
- 资助金额:
$ 10.52万 - 项目类别:
Disrupting Vector-borne Disease Transmission in Complex Urban Environments
阻断复杂城市环境中媒介传播疾病的传播
- 批准号:
8578662 - 财政年份:2013
- 资助金额:
$ 10.52万 - 项目类别:
Mathematical Techniques for Control of Epidemic Trypanosoma cruzi Transmission
控制流行性克氏锥虫传播的数学技术
- 批准号:
8110751 - 财政年份:2010
- 资助金额:
$ 10.52万 - 项目类别:
Mathematical Techniques for Control of Epidemic Trypanosoma cruzi Transmission
控制流行性克氏锥虫传播的数学技术
- 批准号:
7918523 - 财政年份:2009
- 资助金额:
$ 10.52万 - 项目类别:
Mathematical Techniques for Control of Epidemic Trypanosoma cruzi Transmission
控制流行性克氏锥虫传播的数学技术
- 批准号:
7656889 - 财政年份:2008
- 资助金额:
$ 10.52万 - 项目类别:
Mathematical Techniques for Control of Epidemic Trypanosoma cruzi Transmission
控制流行性克氏锥虫传播的数学技术
- 批准号:
8077374 - 财政年份:2008
- 资助金额:
$ 10.52万 - 项目类别:
Mathematical Techniques for Control of Epidemic Trypanosoma cruzi Transmission
控制流行性克氏锥虫传播的数学技术
- 批准号:
7510774 - 财政年份:2008
- 资助金额:
$ 10.52万 - 项目类别:
Mathematical Techniques for Control of Epidemic Trypanosoma cruzi Transmission
控制流行性克氏锥虫传播的数学技术
- 批准号:
7821454 - 财政年份:2008
- 资助金额:
$ 10.52万 - 项目类别:
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