Development of Electronic Multi-Scale Atlas of Human Brain for iPad

描述(申请者提供)：在这项资助中，我们建议建立一个全新概念的电子人脑图谱。多比例尺电子地图集将作为进入大量监督和非监督知识数据库的三维和可视化门户。受监督的数据库将包含爱思唯尔出版的神经科学教科书和地图集。通过我们的电子地图集的可视化界面，用户可以识别感兴趣的结构，并可以访问数据库中相关的组织学面板、图表和结构的文本信息。这一部分版权材料的按需传播可能会彻底改变这些学术出版物在市场上的获取方式。该地图集是根据2010年从爱思唯尔公司引进的出版的地图集图书《人脑白质核磁共振地图集，第二版》编制的。这仍然是市场上唯一一个在立体定位坐标下有广泛的灰色和白色物质3D分割(超过300个结构)的地图集。2012年3月，这本地图集的iPad App版本被推出，这是爱思唯尔和莫里博士在JHU(：//itunes.apple.com/us/app/neuroapps-mri-altas-人类/id508105278？ls=1&mt=8的实验室合作的结果。我们很快意识到，iPad的直观界面和互联网交流的结合，有可能彻底改变地图集的概念和作用。这一新概念基于四个因素：多尺度、立体化、多内容和云支持。新的地图集将是多尺度的，因为它将包含不同分辨率的基于MRI的图像。它们将是三维的，这确保了不同分辨率的图像将相互配准，并共享相同的立体坐标。他们将综合各种出版的教科书和地图集的信息，因此，它将是多内容的。由于地图集将整合大量信息，因此将采用云架构， 其中所请求的信息将按需从中央服务器传送。为了用新的概念创建这份图谱，我们将实现以下两个目标，以测试第一阶段研究的可行性；目标1：利用脑干在1,000、250和150米三个不同分辨率水平的MRI/DTI数据，开发一个多分辨率图谱的平台：这些数据已经在Mori博士的实验室中获得，该实验室已获得Antopy Works的许可。我们将所有图像卷共同注册到当前的iPad atlas空间，并生成多个高倍率2D面板并对其进行注释。然后，这些面板将被整合到iPad Atlas中。目的2：测试多内容数据传输的集中式通信方案：地图集中的每个注释都将链接到解剖工场的监督数据库。我们将用一本教科书《人脑》和一本以组织学为基础的地图集《人类脑干图谱》来测试这一功能，这两本地图集将获得爱思唯尔的授权。我们将开发和测试基于REST的Web服务的通信。

DESCRIPTION (provided by applicant): In this grant, we propose to build an electronic human brain atlas with an entirely new concept. The multi- scale electronic atlas will serve as a three-dimensional and visual portal to a large amount of supervised and unsupervised knowledge database. The supervised database will contain neuroscience textbooks and atlases published from Elsevier. Through the visual interface of our electronic atlas, users can identify structures of interest and can access to related histology panels, diagrams, and text information of the structures in the database. This on-demand dissemination of a section of copyright materials could revolutionize the way these academic publications are accessed in the market. The atlas is based on a published atlas book, "MRI Atlas of Human Brain White Matter, 2nd Edition", which was introduced from Elsevier in 2010. This remains as the only atlas in the market which has an extensive gray and white matter 3D parcellation (more than 300 structures) in stereotaxic coordinates. In March, 2012, an iPad App version of this atlas book was introduced, as a collaboration between Elsevier and Dr. Mori's lab in JHU (://itunes.apple.com/us/app/neuroapps-mri-altas- human/id508105278?ls=1&mt=8). We soon realized that the combination of the intuitive interface of iPad and Internet communication has a potential to revolutionize the concept and role of atlases. This new concept is based on four factors: multi-scale, three-dimensional, multi-content, and Cloud support. The new atlas will be multi-scale because it will incorporate MRI-based images with different resolutions. They will be three-dimensional, which ensures images with different resolutions will be registered each other and share the same stereotaxic coordinates. They will integrate information from various published textbooks and atlases and, therefore, it will be multi-content. Because of the large amount of information will be integrated into the atlas, the cloud architecture will be adopted, in which the requested information will be transferred from a centralized server on-demand. To create this atlas with the new concept, we will accomplish the following two aims to test the feasibility in Phase I study; Aim 1: To develop a platform for a multi-resolution atlas using MRI/DTI data of the brainstem with 3 different resolution levels at 1,000, 250, and 150 m: The data are already available in Dr. Mori's lab, which is licensed to Anatomy Works. We will co-register all image volumes to the current iPad atlas space and generate multiple high-magnification 2D panels and annotate them. These panels will then be incorporated into the iPad Atlas. Aim 2: To test the centralized communication scheme for the multi-content data transfer: Each annotation in the atlas will be linked to the supervised database in Anatomy Works. We will test this function with a textbook, "The Human Brain" and a histology-based atlas, "Atlas of the Human Brainstem", which will be licensed from Elsevier. We will develop and test the communication based on an REST based web service.