Development of Electronic Multi-Scale Atlas of Human Brain for iPad

iPad 版人脑电子多尺度图谱的开发

• 批准号: 8449765
• 负责人: hangyi jiang
• 金额: $ 14.84万
• 依托单位: ANATOMYWORKS, LLC
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8449765
• 关键词: Adopted; Anatomy; Apple; Architecture; Atlases; Autopsy; Books; Brain; Brain Stem; Businesses; Cell Nucleus; Collaborations; Communication; Copyright; Data; Databases; Development; Electronics; Ensure; Environment; Goals; Grant; Histology; Human; Image; Inferior; Institutes; Internet; Knowledge; Lead; Licensing; Link; Location; Magnetic Resonance Imaging; Maps; Marketing; Modeling; Monitor; Morus; Names; Neurosciences; Olives - dietary; PubMed; Publications; Publishing; Research; Resolution; Role; Role Concepts; Scheme; Science; Slice; Source; Structure; System; Testing; Text; Textbooks; Tissues; Visual; Work; base; database structure; gray matter; indexing; interest; next generation; phase 1 study; public health relevance; trafficking; web services; white matter

DESCRIPTION (provided by applicant): In this grant, we propose to build an electronic human brain atlas with an entirely new concept. The multi- scale electronic atlas will serve as a three-dimensional and visual portal to a large amount of supervised and unsupervised knowledge database. The supervised database will contain neuroscience textbooks and atlases published from Elsevier. Through the visual interface of our electronic atlas, users can identify structures of interest and can access to related histology panels, diagrams, and text information of the structures in the database. This on-demand dissemination of a section of copyright materials could revolutionize the way these academic publications are accessed in the market. The atlas is based on a published atlas book, "MRI Atlas of Human Brain White Matter, 2nd Edition", which was introduced from Elsevier in 2010. This remains as the only atlas in the market which has an extensive gray and white matter 3D parcellation (more than 300 structures) in stereotaxic coordinates. In March, 2012, an iPad App version of this atlas book was introduced, as a collaboration between Elsevier and Dr. Mori's lab in JHU (://itunes.apple.com/us/app/neuroapps-mri-altas- human/id508105278?ls=1&mt=8). We soon realized that the combination of the intuitive interface of iPad and Internet communication has a potential to revolutionize the concept and role of atlases. This new concept is based on four factors: multi-scale, three-dimensional, multi-content, and Cloud support. The new atlas will be multi-scale because it will incorporate MRI-based images with different resolutions. They will be three-dimensional, which ensures images with different resolutions will be registered each other and share the same stereotaxic coordinates. They will integrate information from various published textbooks and atlases and, therefore, it will be multi-content. Because of the large amount of information will be integrated into the atlas, the cloud architecture will be adopted, in which the requested information will be transferred from a centralized server on-demand. To create this atlas with the new concept, we will accomplish the following two aims to test the feasibility in Phase I study; Aim 1: To develop a platform for a multi-resolution atlas using MRI/DTI data of the brainstem with 3 different resolution levels at 1,000, 250, and 150 m: The data are already available in Dr. Mori's lab, which is licensed to Anatomy Works. We will co-register all image volumes to the current iPad atlas space and generate multiple high-magnification 2D panels and annotate them. These panels will then be incorporated into the iPad Atlas. Aim 2: To test the centralized communication scheme for the multi-content data transfer: Each annotation in the atlas will be linked to the supervised database in Anatomy Works. We will test this function with a textbook, "The Human Brain" and a histology-based atlas, "Atlas of the Human Brainstem", which will be licensed from Elsevier. We will develop and test the communication based on an REST based web service.

描述（由申请人提供）：在这项资助中，我们建议建立一个全新概念的电子人脑图谱。多尺度电子地图集将为大量有监督和无监督知识数据库提供一个三维和可视化的入口。受监督的数据库将包含爱思唯尔出版的神经科学教科书和地图集。通过我们的电子图谱的可视化界面，用户可以识别感兴趣的结构，并可以访问数据库中相关的组织学面板，图表和结构的文本信息。这种按需传播部分版权材料的方式可能会彻底改变这些学术出版物在市场上的获取方式。该地图集基于2010年从爱思唯尔引进的一本已出版的地图集《人脑白质MRI地图集，第二版》。这仍然是市场上唯一的地图集，具有广泛的灰质和白质3D立体坐标分割（超过300个结构）。2012年3月，作为爱思唯尔和森博士在JHU的实验室的合作，这本地图集的iPad应用程序版本被引入（://itunes.apple.com/us/app/neuroapps-mri-altas- human/id508105278?ls=1&mt=8）。我们很快意识到，iPad的直观界面和互联网通信的结合有可能彻底改变地图册的概念和作用。这个新概念基于四个因素：多尺度、三维、多内容和云支持。新的地图集将是多尺度的，因为它将包含不同分辨率的基于核磁共振成像的图像。它们将是三维的，这确保了不同分辨率的图像将相互注册并共享相同的立体坐标。他们将整合来自各种出版的教科书和地图集的信息，因此，它将是多内容的。由于大量的信息将被集成到地图集中，因此将采用云架构