Multi-scale Human Brain Atlas

AnatomyWorks（AW）正在与约翰斯合作开发人体电子地图集 霍普金斯大学（JHU）。在这个应用中，我们建议开发一个多尺度，多模态的地图集， 人类神经系统我们的地图集将非常独特，因为它将作为各种类型内容的门户 与大脑解剖学和神经科学相关的研究。该项目的最终目标是开发一种新的 基于云的平台，将用于教育，解剖参考和病例报告系统， 医学专家，神经科学研究人员，以及公众。在此期间，我们将开发 并测试了几种类型的多样化内容，这些内容将链接到坐标和结构标签中 地图集其中包括：1）5,000多例临床MRI病例， 在Mori博士的实验室中被分类，2）Troncoso博士实验室中有一个广泛的脑部疾病病理学图书馆 在病理学系。此外，我们还将进一步拓宽内容， 版权材料资源（纸质教科书）和ScienceDirect数据库。这些内容将在 通过AW的名为BrainKnowledge的地图集界面在https://brainknowledge.anatomyworks.org上发布， 这是在我们的第一阶段研究中开发的。在第二阶段研究中，我们将完成第一个版本的 产品通过实现以下目标; 目标1：继续开发参考图谱框架：作为全面的离体MR成像 随后的系列组织学切片正在JHU完成，AW将根据 许可协议。AW和JHU将共同定义体积，表面和各种名称 结构，并将它们作为解剖参考材料部署在BrainKnowledge平台中， 最新的Web界面和数据库技术。 目标2：将内容链接到基于云的BrainKnowledge界面，测试和反馈：我们将链接 上述内容，我们的大脑知识。一种用于基于费用的用户注册的系统， 将开发和测试身份验证和管理以及内容交付。该服务将 发布给合作者以获得反馈并改进界面。 目标3：地图集资源和云平台的分布：我们的地图集资源和云技术 吸引了多家公司和组织的关注。我们继续开发这些资源 进一步拓宽许可用户范围。 目标4：测试用户对BrainKnowledge的贡献：目标1-3旨在创建和分发我们的 内容给用户。然而，云平台的真实的力量是为用户贡献创造平台 和互动。通过应用程序编程接口的现代设计，我们将开发这样一个 平台

AnatomyWorks (AW) is developing electronic atlases of the human body in a collaborative project with Johns Hopkins University (JHU). In this application, we propose to develop a multi-scale, multi-modal atlas of the human nervous system. Our atlas will be highly unique, as it will serve as a portal for various types of content associated with the brain anatomy and neuroscience. The ultimate goal of the project is to develop a new cloud-based platform, which will be used for education, anatomical references, and case-report systems for medical experts, neuroscience researchers, as well as the general public. In this grant period, we will develop and test several types of diverse contents, which will be linked to the coordinates and structural labels inside the atlases. These include; 1) more than 5,000 clinical MRI cases with various types of diseases which are being cataloged in Dr. Mori's lab and 2) an extensive pathology library of brain diseases in Dr. Troncoso's lab in Department of Pathology. In addition, we will further broaden the contents by linking Elsevier's huge resources of copyright materials (paper-based textbooks) and ScienceDirect database. These contents will be delivered through AW's atlas interface called BrainKnowledge at https://brainknowledge.anatomyworks.org, which was developed in our Phase I study. In this Phase II study, we will complete our first version of the product by accomplishing the following aims; Aim 1: Continued development of the reference atlas framework: As the comprehensive ex vivo MR imaging and subsequent serial histology sectioning are being completed in JHU, AW is receiving these materials under a license agreement. AW and JHU will work together to define volumes, surfaces, and names of various structures and deploy them as anatomical referencing materials in the BrainKnowledge platform based on the latest web interface and database technologies. Aim 2: Linkage of the content to the cloud-based BrainKnowledge interface, testing, and feedback: We will link above-mentioned contents to our BrainKnowledge. A system for fee-based user registration, user authentication and management, and content delivery will be developed and tested. The service will be released to collaborators to obtain feedback and improve the interface. Aim 3: Distribution of atlas resources and cloud platforms: Our atlas resources and cloud technologies have been attracting interests from several companies and organizations. We continue to develop these resources to further broaden the scope of licensing users. Aim 4: Testing of user contribution to BrainKnowledge: Aims 1-3 are designed to create and distribute our contents to users. However, the real power of the cloud platform is to create the platform for user contributions and interactions. Through modern design for application programing interfaces, we will develop such a platform.