Multi-scale Human Brain Atlas

多尺度人脑图谱

• 批准号: 9465115
• 负责人: hangyi jiang
• 金额: $ 51.06万
• 依托单位: ANATOMYWORKS, LLC
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9465115
• 关键词: Affect; Agreement; Anatomy; Atlases; Autopsy; Brain; Brain Diseases; Businesses; Case Study; Catalogs; Cells; Clinical; Cloud Computing; Collaborations; Computer Graphics; Contractor; Copyright; Data; Data Storage and Retrieval; Databases; Development; Disease; Education; Feedback; Fees; General Population; Goals; Grant; Health; Histology; Human; Human body; Image; Image Analysis; Imagery; Knowledge; Label; Libraries; Licensing; Link; Location; MRI Scans; Magnetic Resonance Imaging; Medical; Modality; Modeling; Modernization; Names; Nervous system structure; Neurosciences; Paper; Pathologic; Pathology; Process; Radiology Specialty; Reporting; Research; Research Personnel; Resolution; Resources; Sampling; Scanning; Services; Source; Structure; Surface; System; Technology; Testing; Textbooks; Transplantation; Universities; Visualization software; Work; base; brain tissue; cloud based; cloud platform; data resource; design; digital; experience; improved; in vivo; innovation; interest; movie; phase 1 study; phase 2 study; programs; radiologist; search engine; software as a service; success; tool; web interface

AnatomyWorks (AW) is developing electronic atlases of the human body in a collaborative project with Johns Hopkins University (JHU). In this application, we propose to develop a multi-scale, multi-modal atlas of the human nervous system. Our atlas will be highly unique, as it will serve as a portal for various types of content associated with the brain anatomy and neuroscience. The ultimate goal of the project is to develop a new cloud-based platform, which will be used for education, anatomical references, and case-report systems for medical experts, neuroscience researchers, as well as the general public. In this grant period, we will develop and test several types of diverse contents, which will be linked to the coordinates and structural labels inside the atlases. These include; 1) more than 5,000 clinical MRI cases with various types of diseases which are being cataloged in Dr. Mori's lab and 2) an extensive pathology library of brain diseases in Dr. Troncoso's lab in Department of Pathology. In addition, we will further broaden the contents by linking Elsevier's huge resources of copyright materials (paper-based textbooks) and ScienceDirect database. These contents will be delivered through AW's atlas interface called BrainKnowledge at https://brainknowledge.anatomyworks.org, which was developed in our Phase I study. In this Phase II study, we will complete our first version of the product by accomplishing the following aims; Aim 1: Continued development of the reference atlas framework: As the comprehensive ex vivo MR imaging and subsequent serial histology sectioning are being completed in JHU, AW is receiving these materials under a license agreement. AW and JHU will work together to define volumes, surfaces, and names of various structures and deploy them as anatomical referencing materials in the BrainKnowledge platform based on the latest web interface and database technologies. Aim 2: Linkage of the content to the cloud-based BrainKnowledge interface, testing, and feedback: We will link above-mentioned contents to our BrainKnowledge. A system for fee-based user registration, user authentication and management, and content delivery will be developed and tested. The service will be released to collaborators to obtain feedback and improve the interface. Aim 3: Distribution of atlas resources and cloud platforms: Our atlas resources and cloud technologies have been attracting interests from several companies and organizations. We continue to develop these resources to further broaden the scope of licensing users. Aim 4: Testing of user contribution to BrainKnowledge: Aims 1-3 are designed to create and distribute our contents to users. However, the real power of the cloud platform is to create the platform for user contributions and interactions. Through modern design for application programing interfaces, we will develop such a platform.

AW公司正在与约翰斯合作开发人体电子地图集 霍普金斯大学。在这个应用程序中，我们建议开发一个多比例、多模式的地图集 人类神经系统。我们的地图集将是非常独特的，因为它将作为各种类型内容的门户 与大脑解剖学和神经科学有关。该项目的最终目标是开发一种新的 基于云的平台，将用于教育、解剖学参考和病例报告系统 医学专家、神经科学研究人员以及普通民众。在这一授权期内，我们将发展 并测试几种不同类型的内容，这些内容将链接到内部的坐标和结构标签 地图集。这些包括：1)超过5,000例临床MRI病例，患有各种疾病，其中 在森博士的实验室和2)特隆科索博士实验室的大脑疾病的广泛病理图书馆中被编目 病理学系。此外，我们将进一步拓宽内容，链接爱思唯尔的巨型 版权资料(纸质教科书)和Science Direct数据库的资源。这些内容将是 通过AW在https://brainknowledge.anatomyworks.org，上名为BrainKnowledge的地图集界面提供 它是在我们的第一阶段研究中开发的。在这项第二阶段研究中，我们将完成第一个版本的 通过实现以下目标生产产品； 目标1：参考图谱框架的继续发展：作为全面的体外磁共振成像 和随后的连续组织切片正在JHU完成，AW正在接收这些材料 一份许可协议。AW和JHU将共同定义各种体积、曲面和名称 结构，并将其作为解剖学参考材料部署在基于 最新的Web界面和数据库技术。 目标2：将内容链接到基于云的BrainKnowledge界面、测试和反馈：我们将链接 以上内容为我们的大脑知识。一种基于费用的用户注册系统、用户 将开发和测试身份验证和管理以及内容交付。这项服务将是 发布给协作者，以获取反馈并改进界面。 目标3：地图集资源和云平台的分布：我们的地图集资源和云技术 吸引了几家公司和组织的兴趣。我们将继续开发这些资源 进一步拓宽许可用户范围。 目标4：测试用户对BrainKnowledge的贡献：目标1-3旨在创建和分发我们的 内容提供给用户。然而，云平台真正的威力在于打造用户贡献的平台 和互动。通过现代应用编程接口的设计，我们将开发这样一种 站台。