Neurobiology of Social Thinking in Anorexia

厌食症社会思维的神经生物学

• 批准号: 8403950
• 负责人: Carrie Justine McAdams
• 金额: $ 17.15万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8403950
• 关键词: Adolescent; Adult; Anorexia; Anorexia Nervosa; Area; Behavioral; Biological; Biological Factors; Biological Neural Networks; Brain; Brain region; Characteristics; Clinical; Clinical Treatment; Competence; Data; Development; Diagnostic; Dorsal; Eating Disorders; Emotional; Emotions; Equipment and supply inventories; Female; Functional Magnetic Resonance Imaging; Glucose; Goals; Human; Impairment; Individual; Intervention; K-Series Research Career Programs; Knowledge; Link; Measures; Medical; Medical History; Mentors; Neurobiology; Neurocognitive; Participant; Pathology; Patients; Personality; Phenotype; Pilot Projects; Problem Solving; Process; Psychological Factors; Recording of previous events; Recovery; Request for Applications; Research; Research Personnel; Research Project Grants; Residencies; Resolution; Rest; Rewards; Sample Size; Self Concept; Self Perception; Severities; Social Identification; Social Problems; Staging; Starvation; Structure of superior temporal sulcus; Symptoms; Thinking; Time; Training; Treatment Protocols; Underweight; Weight; Woman; career; cognitive neuroscience; evidence base; improved; interest; meetings; neural circuit; neuroimaging; patient oriented; psychologic; relating to nervous system; self esteem; social; social cognition; theories; trait; young adult

DESCRIPTION (provided by applicant): This K-23 Mentored Patient-Oriented Career Development Award application requests support to provide training for the applicant to become a neuroimaging researcher in human cognitive neuroscience specializing in understanding the illness, anorexia nervosa and to perform a research project that will investigate the linkages between neural correlates of social thinking and the pathology of anorexia nervosa. During residency, the applicant's research background as a cortical neurophysiologist led her to begin a pilot project utilizing functional neuroimaging tasks in eating disorders. This project identified three cortical regions with different activation in thinking about one's own self-identity and understanding relationships between others in patients in the process of recovering from anorexia nervosa. The proposed project will now examine the activation of these regions: the cingulate, the precuneus, and the temporoparietal junction in three different subject groups: healthy controls, currently ill anorexia nervosa patients, and fully recovered anorexia nervosa patients. These comparisons will improve our understanding of cortical changes associated with illness and recovery in anorexia nervosa. In addition to the neuroimaging data, each participant will complete assessments providing psychiatric and medical history, psychological scales related to the fMRI tasks, and neurocognitive measures. Activation of these neural regions by the fMRI tasks will also be correlated with the assessments to distinguish between cortical differences that relate specifically to the presence of the illness and differences that relate to other psychological measures and may reflect a trait of patients that have anorexia nervosa. These studies will allow the applicant to meet her immediate career goal: development as an independent translational neuroimaging researcher in anorexia nervosa. With this study and training, the applicant will be prepared to meet her long-term career goal of becoming an independent investigator examining the relationship between biological mechanisms and psychological function in both the development and resolution of anorexia nervosa.

描述（由申请人提供）：此 K-23 指导性患者导向职业发展奖申请要求支持为申请人提供培训，使其成为人类认知神经科学领域的神经影像研究员，专门了解神经性厌食症这种疾病，并开展一个研究项目，调查社会思维的神经相关因素与神经性厌食症病理学之间的联系。在住院医师实习期间，申请人作为皮质神经生理学家的研究背景促使她开始了一个利用功能性神经影像任务治疗饮食失调的试点项目。该项目确定了神经性厌食症患者在思考自我认同和理解他人关系时具有不同激活程度的三个皮质区域。拟议的项目现在将检查三个不同受试者组中这些区域的激活：扣带回、楔前叶和颞顶交界处：健康对照组、目前患病的神经性厌食症患者和完全康复的神经性厌食症患者。这些比较将提高我们对与神经性厌食症疾病和恢复相关的皮质变化的理解。除了神经影像数据外，每位参与者还将完成评估，提供精神病史和病史、与功能磁共振成像任务相关的心理量表以及神经认知测量。功能磁共振成像任务对这些神经区域的激活也将与评估相关，以区分与疾病存在具体相关的皮质差异和与其他心理测量相关的差异，并可能反映神经性厌食症患者的特征。这些研究将使申请人能够实现她近期的职业目标：发展成为神经性厌食症的独立转化神经影像研究员。通过这项研究和培训，申请人将准备好实现她的长期职业目标，即成为一名独立研究者，研究神经性厌食症的发展和解决中的生物机制和心理功能之间的关系。